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Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis.
BMC Neurol. 2019 Nov 13; 19(1):284.BN

Abstract

BACKGROUND

We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD).

METHODS

We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package.

RESULTS

Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml).

CONCLUSION

There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).

Authors+Show Affiliations

Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China. 2279262895@qq.com. School of Clinical Medicine, Gansu university of Traditional Chinese medicine, No. 35 of Dingxi East Road, Lanzhou City, Gansu Province, 730000, People's Republic of China. 2279262895@qq.com.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.Department of Neurology,Gansu Provincial People's Hospital, No.204, Donggang West Road, Lanzhou, 730000, Gansu, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

31722673

Citation

Chai, Bingyan, et al. "Vitamin D Deficiency as a Risk Factor for Dementia and Alzheimer's Disease: an Updated Meta-analysis." BMC Neurology, vol. 19, no. 1, 2019, p. 284.
Chai B, Gao F, Wu R, et al. Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis. BMC Neurol. 2019;19(1):284.
Chai, B., Gao, F., Wu, R., Dong, T., Gu, C., Lin, Q., & Zhang, Y. (2019). Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis. BMC Neurology, 19(1), 284. https://doi.org/10.1186/s12883-019-1500-6
Chai B, et al. Vitamin D Deficiency as a Risk Factor for Dementia and Alzheimer's Disease: an Updated Meta-analysis. BMC Neurol. 2019 Nov 13;19(1):284. PubMed PMID: 31722673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis. AU - Chai,Bingyan, AU - Gao,Fulin, AU - Wu,Ruipeng, AU - Dong,Tong, AU - Gu,Cheng, AU - Lin,Qiaoran, AU - Zhang,Yi, Y1 - 2019/11/13/ PY - 2019/03/23/received PY - 2019/10/16/accepted PY - 2019/11/15/entrez PY - 2019/11/15/pubmed PY - 2020/1/28/medline KW - Alzheimer’s disease KW - Dementia KW - Meta-analysis KW - Vitamin D deficiency SP - 284 EP - 284 JF - BMC neurology JO - BMC Neurol VL - 19 IS - 1 N2 - BACKGROUND: We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). METHODS: We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. RESULTS: Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). CONCLUSION: There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml). SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/31722673/Vitamin_D_deficiency_as_a_risk_factor_for_dementia_and_Alzheimer's_disease:_an_updated_meta_analysis_ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1500-6 DB - PRIME DP - Unbound Medicine ER -