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Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery.
Cureus. 2019 Sep 26; 11(9):e5768.C

Abstract

Marine-Lenhart syndrome (MLS), a rare form of hyperthyroidism, is the coexistence of Graves' disease (GD) and autonomously functioning thyroid nodule(s). Herein, we report a case of recurrent goiter presented with MLS. A 52-year-old man presented at our department with recurrent goiter, exophthalmia, and symptoms of hyperthyroidism. In addition to clinical signs and thyroid eye disease, suppressed thyroid-stimulating hormone (TSH) and high free thyroxine (FT4) and autoantibody levels lead to the diagnosis of GD. Thyroid ultrasound and nuclear scan showed the presence of a large, solid, and functioning "hot" nodule in the right lobe. Thus, in recurrent goiter cases, the diagnosis was MLS, wherein autoimmune hyperthyroidism was associated with the functioning nodule. Following medical control with methimazole, the patient underwent total excision of recurrent goiter. Levothyroxine (LT4) therapy was prescribed to maintain normal serum hormone levels. At follow-up, the gradual decrease in serum levels of autoantibody was detected. This patient is a very rare example of MLS that occurs in recurrent goiter case. Clinical signs, serum hormone and autoantibody levels, thyroid ultrasound, and nuclear scan establish the correct diagnosis of this specific and rare disorder. Thyroid surgery and total removal of glandular tissue provides definitive control of hyperthyroidism and obviates autoimmune reaction.

Authors+Show Affiliations

Surgery, Duzce University Medical Faculty, Duzce, TUR.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31723527

Citation

Gurleyik, Emin. "Recurrent Goiter Presented With Marine-Lenhart Syndrome 27 Years After Initial Surgery." Cureus, vol. 11, no. 9, 2019, pp. e5768.
Gurleyik E. Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery. Cureus. 2019;11(9):e5768.
Gurleyik, E. (2019). Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery. Cureus, 11(9), e5768. https://doi.org/10.7759/cureus.5768
Gurleyik E. Recurrent Goiter Presented With Marine-Lenhart Syndrome 27 Years After Initial Surgery. Cureus. 2019 Sep 26;11(9):e5768. PubMed PMID: 31723527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent Goiter Presented with Marine-Lenhart Syndrome 27 Years After Initial Surgery. A1 - Gurleyik,Emin, Y1 - 2019/09/26/ PY - 2019/11/15/entrez PY - 2019/11/15/pubmed PY - 2019/11/15/medline KW - adenoma KW - graves' disease KW - hyperthyroidism KW - nodule KW - thyroid SP - e5768 EP - e5768 JF - Cureus JO - Cureus VL - 11 IS - 9 N2 - Marine-Lenhart syndrome (MLS), a rare form of hyperthyroidism, is the coexistence of Graves' disease (GD) and autonomously functioning thyroid nodule(s). Herein, we report a case of recurrent goiter presented with MLS. A 52-year-old man presented at our department with recurrent goiter, exophthalmia, and symptoms of hyperthyroidism. In addition to clinical signs and thyroid eye disease, suppressed thyroid-stimulating hormone (TSH) and high free thyroxine (FT4) and autoantibody levels lead to the diagnosis of GD. Thyroid ultrasound and nuclear scan showed the presence of a large, solid, and functioning "hot" nodule in the right lobe. Thus, in recurrent goiter cases, the diagnosis was MLS, wherein autoimmune hyperthyroidism was associated with the functioning nodule. Following medical control with methimazole, the patient underwent total excision of recurrent goiter. Levothyroxine (LT4) therapy was prescribed to maintain normal serum hormone levels. At follow-up, the gradual decrease in serum levels of autoantibody was detected. This patient is a very rare example of MLS that occurs in recurrent goiter case. Clinical signs, serum hormone and autoantibody levels, thyroid ultrasound, and nuclear scan establish the correct diagnosis of this specific and rare disorder. Thyroid surgery and total removal of glandular tissue provides definitive control of hyperthyroidism and obviates autoimmune reaction. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31723527/Recurrent_Goiter_Presented_with_Marine_Lenhart_Syndrome_27_Years_After_Initial_Surgery_ DB - PRIME DP - Unbound Medicine ER -
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