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Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study.
Environ Health. 2019 11 14; 18(1):96.EH

Abstract

BACKGROUND

The associations between maternal exposure to ambient PM2.5 during pregnancy and the risk of premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM) are controversial. And no relevant study has been conducted in Asia. This study aimed to determine the association between maternal exposure to ambient PM2.5 during pregnancy and the risk of (P)PROM.

METHODS

A cohort study including all singleton births in a hospital located in Central China from January 2015 through December 2017 was conducted. Multivariable logistic regression models, stratified analysis, generalized additive model, and two-piece-wise linear regression were conducted to evaluate how exposure to ambient PM2.5 during pregnancy is associated with the risks of PROM and PPROM.

RESULTS

A total of 4364 participants were included in the final analysis, where 11.71 and 2.34% of births were complicated by PROM and PPROM, respectively. The level of PM2.5 exhibited a degree of seasonal variation, and its median concentrations were 63.7, 59.3, 55.8, and 61.8 μg/m3 for the first trimester, second trimester, third trimester, and the whole duration of pregnancy, respectively. After adjustment for potential confounders, PROM was positively associated with PM2.5 exposure (per 10 μg/m3) [Odds Ratio (OR) = 1.14, 95% Confidence Interval (CI), 1.02-1.26 for the first trimester; OR = 1.09, 95% CI, 1.00-1.18 for the second trimester; OR = 1.13, 95% CI, 1.03-1.24 for the third trimester; OR = 1.35, 95% CI, 1.12-1.63 for the whole pregnancy]. PPROM had positive relationship with PM2.5 exposure (per 10 μg/m3) (OR = 1.17, 95% CI, 0.94-1.45 for first trimester; OR = 1.11, 95% CI, 0.92-1.33 for second trimester; OR = 1.19, 95% CI, 0.99-1.44 for third trimester; OR = 1.53, 95% CI, 1.03-2.27 for the whole pregnancy) Positive trends between the acute exposure window (mean concentration of PM2.5 in the last week and day of pregnancy) and risks of PROM and PPROM were also observed.

CONCLUSIONS

Exposure to ambient PM2.5 during pregnancy was associated with the risk of PROM and PPROM.

Authors+Show Affiliations

Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Organisation for Economic Co-operation and Development, 92100, Boulogne-Billancourt, France.Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. chengyunliu@hust.edu.cn. The First People's Hospital of Jiangxia District, Wuhan City & Union Jiangnan Hospital, HUST, Wuhan, 430200, China. chengyunliu@hust.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31727105

Citation

Wang, Kun, et al. "Maternal Exposure to Ambient Fine Particulate Matter and Risk of Premature Rupture of Membranes in Wuhan, Central China: a Cohort Study." Environmental Health : a Global Access Science Source, vol. 18, no. 1, 2019, p. 96.
Wang K, Tian Y, Zheng H, et al. Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study. Environ Health. 2019;18(1):96.
Wang, K., Tian, Y., Zheng, H., Shan, S., Zhao, X., & Liu, C. (2019). Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study. Environmental Health : a Global Access Science Source, 18(1), 96. https://doi.org/10.1186/s12940-019-0534-y
Wang K, et al. Maternal Exposure to Ambient Fine Particulate Matter and Risk of Premature Rupture of Membranes in Wuhan, Central China: a Cohort Study. Environ Health. 2019 11 14;18(1):96. PubMed PMID: 31727105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study. AU - Wang,Kun, AU - Tian,Yu, AU - Zheng,Huabo, AU - Shan,Shengshuai, AU - Zhao,Xiaofang, AU - Liu,Chengyun, Y1 - 2019/11/14/ PY - 2019/05/15/received PY - 2019/10/18/accepted PY - 2019/11/16/entrez PY - 2019/11/16/pubmed PY - 2020/3/14/medline KW - Cohort study KW - Maternal exposure KW - PM2.5 (airborne particulate matter with an aerodynamic diameter of 0.25 μm or less) KW - PPROM (preterm premature rupture of membranes) KW - PROM (premature rupture of membranes) SP - 96 EP - 96 JF - Environmental health : a global access science source JO - Environ Health VL - 18 IS - 1 N2 - BACKGROUND: The associations between maternal exposure to ambient PM2.5 during pregnancy and the risk of premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM) are controversial. And no relevant study has been conducted in Asia. This study aimed to determine the association between maternal exposure to ambient PM2.5 during pregnancy and the risk of (P)PROM. METHODS: A cohort study including all singleton births in a hospital located in Central China from January 2015 through December 2017 was conducted. Multivariable logistic regression models, stratified analysis, generalized additive model, and two-piece-wise linear regression were conducted to evaluate how exposure to ambient PM2.5 during pregnancy is associated with the risks of PROM and PPROM. RESULTS: A total of 4364 participants were included in the final analysis, where 11.71 and 2.34% of births were complicated by PROM and PPROM, respectively. The level of PM2.5 exhibited a degree of seasonal variation, and its median concentrations were 63.7, 59.3, 55.8, and 61.8 μg/m3 for the first trimester, second trimester, third trimester, and the whole duration of pregnancy, respectively. After adjustment for potential confounders, PROM was positively associated with PM2.5 exposure (per 10 μg/m3) [Odds Ratio (OR) = 1.14, 95% Confidence Interval (CI), 1.02-1.26 for the first trimester; OR = 1.09, 95% CI, 1.00-1.18 for the second trimester; OR = 1.13, 95% CI, 1.03-1.24 for the third trimester; OR = 1.35, 95% CI, 1.12-1.63 for the whole pregnancy]. PPROM had positive relationship with PM2.5 exposure (per 10 μg/m3) (OR = 1.17, 95% CI, 0.94-1.45 for first trimester; OR = 1.11, 95% CI, 0.92-1.33 for second trimester; OR = 1.19, 95% CI, 0.99-1.44 for third trimester; OR = 1.53, 95% CI, 1.03-2.27 for the whole pregnancy) Positive trends between the acute exposure window (mean concentration of PM2.5 in the last week and day of pregnancy) and risks of PROM and PPROM were also observed. CONCLUSIONS: Exposure to ambient PM2.5 during pregnancy was associated with the risk of PROM and PPROM. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/31727105/Maternal_exposure_to_ambient_fine_particulate_matter_and_risk_of_premature_rupture_of_membranes_in_Wuhan_Central_China:_a_cohort_study_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0534-y DB - PRIME DP - Unbound Medicine ER -