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Focus on Middle East respiratory syndrome coronavirus (MERS-CoV).
Med Mal Infect. 2020 May; 50(3):243-251.MM

Abstract

Since the first case of human infection by the Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in June 2012, more than 2260 cases of confirmed MERS-CoV infection and 803 related deaths have been reported since the 16th of October 2018. The vast majority of these cases (71%) were reported in Saudi Arabia but the epidemic has now spread to 27 countries and has not ceased 6 years later, unlike SARS-CoV that disappeared a little less than 2 years after emerging. Due to the high fatality rate observed in MERS-CoV infected patients (36%), much effort has been put into understanding the origin and pathophysiology of this novel coronavirus to prevent it from becoming endemic in humans. This review focuses in particular on the origin, epidemiology and clinical manifestations of MERS-CoV, as well as the diagnosis and treatment of infected patients. The experience gained over recent years on how to manage the different risks related to this kind of epidemic will be key to being prepared for future outbreaks of communicable disease.

Authors+Show Affiliations

Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP-HP, Paris, France.Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP-HP, Paris, France.Service des maladies infectieuses et tropicales, hôpitaux universitaires Pitié-Salpêtrière Charles Foix, AP-HP, Paris, France.Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP-HP, Paris, France.Inserm, Laboratoire de Virologie, IAME, UMR 1137, Hôpital Bichat, Sorbonne Paris Cité, Université Paris Diderot, AP-HP, Paris, France. Electronic address: benoit.visseaux@aphp.fr.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31727466

Citation

Bleibtreu, A, et al. "Focus On Middle East Respiratory Syndrome Coronavirus (MERS-CoV)." Medecine Et Maladies Infectieuses, vol. 50, no. 3, 2020, pp. 243-251.
Bleibtreu A, Bertine M, Bertin C, et al. Focus on Middle East respiratory syndrome coronavirus (MERS-CoV). Med Mal Infect. 2020;50(3):243-251.
Bleibtreu, A., Bertine, M., Bertin, C., Houhou-Fidouh, N., & Visseaux, B. (2020). Focus on Middle East respiratory syndrome coronavirus (MERS-CoV). Medecine Et Maladies Infectieuses, 50(3), 243-251. https://doi.org/10.1016/j.medmal.2019.10.004
Bleibtreu A, et al. Focus On Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Med Mal Infect. 2020;50(3):243-251. PubMed PMID: 31727466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Focus on Middle East respiratory syndrome coronavirus (MERS-CoV). AU - Bleibtreu,A, AU - Bertine,M, AU - Bertin,C, AU - Houhou-Fidouh,N, AU - Visseaux,B, Y1 - 2019/11/11/ PY - 2018/09/16/received PY - 2018/10/22/revised PY - 2019/10/08/accepted PY - 2019/11/16/pubmed PY - 2020/9/20/medline PY - 2019/11/16/entrez KW - Coronavirus KW - Emerging disease KW - MERS-CoV KW - Maladies émergentes KW - Pneumonia KW - Pneumonie SP - 243 EP - 251 JF - Medecine et maladies infectieuses JO - Med Mal Infect VL - 50 IS - 3 N2 - Since the first case of human infection by the Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia in June 2012, more than 2260 cases of confirmed MERS-CoV infection and 803 related deaths have been reported since the 16th of October 2018. The vast majority of these cases (71%) were reported in Saudi Arabia but the epidemic has now spread to 27 countries and has not ceased 6 years later, unlike SARS-CoV that disappeared a little less than 2 years after emerging. Due to the high fatality rate observed in MERS-CoV infected patients (36%), much effort has been put into understanding the origin and pathophysiology of this novel coronavirus to prevent it from becoming endemic in humans. This review focuses in particular on the origin, epidemiology and clinical manifestations of MERS-CoV, as well as the diagnosis and treatment of infected patients. The experience gained over recent years on how to manage the different risks related to this kind of epidemic will be key to being prepared for future outbreaks of communicable disease. SN - 1769-6690 UR - https://www.unboundmedicine.com/medline/citation/31727466/Focus_on_Middle_East_respiratory_syndrome_coronavirus__MERS_CoV__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0399-077X(19)31054-6 DB - PRIME DP - Unbound Medicine ER -