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Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report.
Mult Scler Relat Disord. 2020 Feb; 38:101500.MS

Abstract

Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-ab) have been detected in various disorders of the central nervous system including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorders (NMOSD), optic neuritis, myelitis, and cortical encephalitis. We report an atypical case of MOG-ab-associated encephalomyelitis with part of the clinical manifestations resembling limbic encephalitis. Multifocal, hyperintense, bilateral lesions predominantly affecting the white matter on brain magnetic resonance imaging and marked response to steroid therapy were compatible with a MOG-ab-associated disease. This case illustrates that MOG-ab-associated disease should be considered in encephalomyelitis involving the bilateral limbic system.

Authors+Show Affiliations

Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan. Electronic address: uchigamihirokazu1@yahoo.co.jp.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.Department of Neurology, National Hospital Organization Yonezawa Hospital, Yamagata, Japan.Department of Neurology, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31733424

Citation

Uchigami, Hirokazu, et al. "Anti-myelin Oligodendrocyte Glycoprotein Antibody-positive Acute Disseminated Encephalomyelitis Mimicking Limbic Encephalitis: a Case Report." Multiple Sclerosis and Related Disorders, vol. 38, 2020, p. 101500.
Uchigami H, Arai N, Sekiguchi M, et al. Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report. Mult Scler Relat Disord. 2020;38:101500.
Uchigami, H., Arai, N., Sekiguchi, M., Ogawa, A., Yasuda, T., Seto, A., Takahashi, T., & Takeuchi, S. (2020). Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report. Multiple Sclerosis and Related Disorders, 38, 101500. https://doi.org/10.1016/j.msard.2019.101500
Uchigami H, et al. Anti-myelin Oligodendrocyte Glycoprotein Antibody-positive Acute Disseminated Encephalomyelitis Mimicking Limbic Encephalitis: a Case Report. Mult Scler Relat Disord. 2020;38:101500. PubMed PMID: 31733424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-myelin oligodendrocyte glycoprotein antibody-positive acute disseminated encephalomyelitis mimicking limbic encephalitis: A case report. AU - Uchigami,Hirokazu, AU - Arai,Noritoshi, AU - Sekiguchi,Mariko, AU - Ogawa,Atsubumi, AU - Yasuda,Tsutomu, AU - Seto,Akiko, AU - Takahashi,Toshiyuki, AU - Takeuchi,Sousuke, Y1 - 2019/11/05/ PY - 2019/06/19/received PY - 2019/08/13/revised PY - 2019/11/04/accepted PY - 2019/11/17/pubmed PY - 2019/11/17/medline PY - 2019/11/17/entrez KW - Acute disseminated encephalomyelitis KW - Anti-myelin oligodendrocyte glycoprotein antibodies KW - Bilateral limbic system KW - Limbic encephalitis SP - 101500 EP - 101500 JF - Multiple sclerosis and related disorders JO - Mult Scler Relat Disord VL - 38 N2 - Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-ab) have been detected in various disorders of the central nervous system including acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorders (NMOSD), optic neuritis, myelitis, and cortical encephalitis. We report an atypical case of MOG-ab-associated encephalomyelitis with part of the clinical manifestations resembling limbic encephalitis. Multifocal, hyperintense, bilateral lesions predominantly affecting the white matter on brain magnetic resonance imaging and marked response to steroid therapy were compatible with a MOG-ab-associated disease. This case illustrates that MOG-ab-associated disease should be considered in encephalomyelitis involving the bilateral limbic system. SN - 2211-0356 UR - https://www.unboundmedicine.com/medline/citation/31733424/Anti_myelin_oligodendrocyte_glycoprotein_antibody_positive_acute_disseminated_encephalomyelitis_mimicking_limbic_encephalitis:_A_case_report_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-0348(19)30489-4 DB - PRIME DP - Unbound Medicine ER -