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Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis.
Clin Neurol Neurosurg. 2020 01; 188:105587.CN

Abstract

Epidemiological studies evaluating the associations of plasma homocysteine (Hcy), folate and vitamin B12 levels with Parkinson's disease (PD) in China have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize the relationships. PubMed, Cochrane Library, Elsevier Science Direct, Springer, CNKI (China National Knowledge Infrastructure), and Wanfang (Chinese) databases were searched for eligible studies from January 2000 to November 2018. The pooled standardized mean difference (SMD), Fisher's Z and corresponding 95% confidence interval (95% CI) were calculated with fix-effects or random-effects model. In total, 26 case-control studies and 1 cross-sectional study were included in this meta-analysis. The results showed that: (1) PD patients had a higher Hcy level than the control individuals (P <0.05). After stratification subgroup, significant differences of plasma Hcy level between PD patients and controls were found in subgroup with sample size< 100, sample size ≥100, as well as in the subgroup analysis by levodopa therapy. (2) Both plasma folate and vitamin B12 levels were lower in the PD patients compared with the control group (P <0.05). (3) Plasma Hcy level was negatively correlated with plasma levels of folate and vitamin Bl2 in PD patients (P <0.05). (4) The relevant influential factors of plasma Hcy level in PD patients were clinical types, Hoehn & Yahr stage, cognitive impairment, or levodopa therapy (P <0.05). In conclusion, PD patients had a higher Hcy level in China. Multiple factors were associated with Hcy levels of Chinese PD patients.

Authors+Show Affiliations

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, China. Electronic address: 18715525187@qq.com.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230031, China. Electronic address: 296108087@qq.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

31733593

Citation

Dong, Bao, and Rongrong Wu. "Plasma Homocysteine, Folate and Vitamin B12 Levels in Parkinson's Disease in China: a Meta-analysis." Clinical Neurology and Neurosurgery, vol. 188, 2020, p. 105587.
Dong B, Wu R. Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis. Clin Neurol Neurosurg. 2020;188:105587.
Dong, B., & Wu, R. (2020). Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis. Clinical Neurology and Neurosurgery, 188, 105587. https://doi.org/10.1016/j.clineuro.2019.105587
Dong B, Wu R. Plasma Homocysteine, Folate and Vitamin B12 Levels in Parkinson's Disease in China: a Meta-analysis. Clin Neurol Neurosurg. 2020;188:105587. PubMed PMID: 31733593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma homocysteine, folate and vitamin B12 levels in Parkinson's disease in China: A meta-analysis. AU - Dong,Bao, AU - Wu,Rongrong, Y1 - 2019/11/04/ PY - 2019/03/04/received PY - 2019/10/20/revised PY - 2019/11/03/accepted PY - 2019/11/17/pubmed PY - 2021/4/29/medline PY - 2019/11/17/entrez KW - Folate KW - Homocysteine KW - Meta-analysis KW - Parkinson’s disease KW - Vitamin B12 SP - 105587 EP - 105587 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 188 N2 - Epidemiological studies evaluating the associations of plasma homocysteine (Hcy), folate and vitamin B12 levels with Parkinson's disease (PD) in China have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize the relationships. PubMed, Cochrane Library, Elsevier Science Direct, Springer, CNKI (China National Knowledge Infrastructure), and Wanfang (Chinese) databases were searched for eligible studies from January 2000 to November 2018. The pooled standardized mean difference (SMD), Fisher's Z and corresponding 95% confidence interval (95% CI) were calculated with fix-effects or random-effects model. In total, 26 case-control studies and 1 cross-sectional study were included in this meta-analysis. The results showed that: (1) PD patients had a higher Hcy level than the control individuals (P <0.05). After stratification subgroup, significant differences of plasma Hcy level between PD patients and controls were found in subgroup with sample size< 100, sample size ≥100, as well as in the subgroup analysis by levodopa therapy. (2) Both plasma folate and vitamin B12 levels were lower in the PD patients compared with the control group (P <0.05). (3) Plasma Hcy level was negatively correlated with plasma levels of folate and vitamin Bl2 in PD patients (P <0.05). (4) The relevant influential factors of plasma Hcy level in PD patients were clinical types, Hoehn & Yahr stage, cognitive impairment, or levodopa therapy (P <0.05). In conclusion, PD patients had a higher Hcy level in China. Multiple factors were associated with Hcy levels of Chinese PD patients. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/31733593/Plasma_homocysteine_folate_and_vitamin_B12_levels_in_Parkinson's_disease_in_China:_A_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(19)30383-X DB - PRIME DP - Unbound Medicine ER -