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ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Med Hypotheses. 2020 Feb; 135:109440.MH

Abstract

There are a pretty number of research demonstrating that ADAMTS4 and ADAMTS5 playing primary roles in the degradation of cartilage during inflammatory joint diseases like osteoarthritis (OA). Because Kashin-Beck Disease (KBD) has been found to own the common pathological changes and symptoms with OA, and is regarded as the specific type of osteoarthritis, it's reasonable to believe that ADAMTS4 and ADAMTS5 may exert an enormous functions on the injury of cartilage of the KBD and may be potential molecular therapeutic targets for KBD.

Authors+Show Affiliations

School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China; Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission (Xi'an Jiaotong University), Xi'an 710061, PR China; Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region (Xi'an Jiaotong University), Xi'an 710061, PR China. Electronic address: alison@stu.xjtu.edu.cn.School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address: yuyan@mail.xjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31734379

Citation

Meng, Peilin, et al. "ADAMTS4 and ADAMTS5 May Be Considered as New Molecular Therapeutic Targets for Cartilage Damages With Kashin-Beck Disease." Medical Hypotheses, vol. 135, 2020, p. 109440.
Meng P, Zhang F, Zhang Y, et al. ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. Med Hypotheses. 2020;135:109440.
Meng, P., Zhang, F., Zhang, Y., Wei, H., Tan, S., Guo, X., Wang, S., & Yu, Y. (2020). ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. Medical Hypotheses, 135, 109440. https://doi.org/10.1016/j.mehy.2019.109440
Meng P, et al. ADAMTS4 and ADAMTS5 May Be Considered as New Molecular Therapeutic Targets for Cartilage Damages With Kashin-Beck Disease. Med Hypotheses. 2020;135:109440. PubMed PMID: 31734379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. AU - Meng,Peilin, AU - Zhang,Feng'e, AU - Zhang,Yanan, AU - Wei,Haiyan, AU - Tan,SiJia, AU - Guo,Xiong, AU - Wang,Sen, AU - Yu,Yan, Y1 - 2019/10/18/ PY - 2019/09/05/received PY - 2019/10/10/revised PY - 2019/10/17/accepted PY - 2019/11/18/pubmed PY - 2019/11/18/medline PY - 2019/11/18/entrez KW - ADAMTS4 KW - ADAMTS5 KW - Kashin-Beck disease KW - Molecular therapeutic target SP - 109440 EP - 109440 JF - Medical hypotheses JO - Med. Hypotheses VL - 135 N2 - There are a pretty number of research demonstrating that ADAMTS4 and ADAMTS5 playing primary roles in the degradation of cartilage during inflammatory joint diseases like osteoarthritis (OA). Because Kashin-Beck Disease (KBD) has been found to own the common pathological changes and symptoms with OA, and is regarded as the specific type of osteoarthritis, it's reasonable to believe that ADAMTS4 and ADAMTS5 may exert an enormous functions on the injury of cartilage of the KBD and may be potential molecular therapeutic targets for KBD. SN - 1532-2777 UR - https://www.unboundmedicine.com/medline/citation/31734379/ADAMTS4_and_ADAMTS5_may_be_considered_as_new_molecular_therapeutic_targets_for_cartilage_damages_with_Kashin-Beck_Disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(19)30989-2 DB - PRIME DP - Unbound Medicine ER -
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