Tags

Type your tag names separated by a space and hit enter

Spirulina platensis ameliorates the sub chronic toxicities of lead in rabbits via anti-oxidative, anti- inflammatory, and immune stimulatory properties.
Sci Total Environ. 2020 Jan 20; 701:134879.ST

Abstract

Lead acetate (Pb) is an oldest and widespread environmental toxicant that led to cumulative injury in humans and all living organisms through induction of oxidative stress. Spirulina platensis (SP) is a cyanobacteria with strong antioxidant, anti-inflammatory, and immune stimulatory effects. In this study, the ameliorative effect of SP was evaluated against the dietary sub chronic lead toxicities in rabbits. A total number of 75 male New Zealand rabbits were allocated randomly into 5 groups; the first group feed on basal diet alone and served as control group, the second group feed on basal diet + 100 mg Pb /kg diet, the third, fourth, and the fifth groups feed on basal diet + 100 mg Pb /kg diet + SP (0.5, 1, or 1.5 g/kg diet; respectively), the experiment was extended for 8 weeks. Results revealed a significant improvement in some of growth parameters like final body weight and daily weight gain, blood parameters in rabbits treated with SP at level 1.5 g/kg diet followed by those receiving SP 1 g/kg diet. However, a significant decrease in blood parameters, liver function, renal parameters, lipid profiles, oxidative parameters (malondialdehyde and protein carbonyl), heart indices (creatine phosphokinase, creatine kinase-muscle/brain, lactate dehydrogenase), total Pb residues in muscles, and area percent of nuclear factor kappa b immune expression were reported in groups supplemented with different levels of SP. Pathologic analysis of liver, kidneys, and heart revealed moderate to severe degenerative and necrotic changes in Pb- exposed rabbits, which is ameliorated with supplementation of SP in different levels. Conclusively, dietary supplementation of SP at different levels attenuated the cumulative effect of lead in rabbits in dose-dependent manner; this attenuation may be attributed to its anti-oxidative, anti-inflammatory, as well as its immune stimulant effect.

Authors+Show Affiliations

Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Jordan; Department of Biology, Faculty of Science, Al-Hussein Bin Talal University, Jordan.Department of Pathology, Faculty of Veterinary Medicine, Alexandria University, 22758 Edfina, Egypt.Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.Veterinary Department, Faculty of Agriculture and Veterinary Medicine, Thamar University, Dhamar 2153, Yemen.Department of Medical Analysis, Princess Aisha Bint Al-Hussein Faculty of Nursing and Health Sciences, Al-Hussein Bin Talal University, Jordan; Department of Biology, Faculty of Science, Al-Hussein Bin Talal University, Jordan.Department of Biology, Faculty of Science, King Faisal University, Al-Hassa, Saudi Arabia.Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, F-25030 Besançon Cedex, France. Electronic address: lotfi.aleya@univ-fcomte.fr.Department of Animal Production, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31734488

Citation

Aladaileh, Saleem H., et al. "Spirulina Platensis Ameliorates the Sub Chronic Toxicities of Lead in Rabbits Via Anti-oxidative, Anti- Inflammatory, and Immune Stimulatory Properties." The Science of the Total Environment, vol. 701, 2020, p. 134879.
Aladaileh SH, Khafaga AF, Abd El-Hack ME, et al. Spirulina platensis ameliorates the sub chronic toxicities of lead in rabbits via anti-oxidative, anti- inflammatory, and immune stimulatory properties. Sci Total Environ. 2020;701:134879.
Aladaileh, S. H., Khafaga, A. F., Abd El-Hack, M. E., Al-Gabri, N. A., Abukhalil, M. H., Alfwuaires, M. A., Bin-Jumah, M., Alkahtani, S., Abdel-Daim, M. M., Aleya, L., & Abdelnour, S. (2020). Spirulina platensis ameliorates the sub chronic toxicities of lead in rabbits via anti-oxidative, anti- inflammatory, and immune stimulatory properties. The Science of the Total Environment, 701, 134879. https://doi.org/10.1016/j.scitotenv.2019.134879
Aladaileh SH, et al. Spirulina Platensis Ameliorates the Sub Chronic Toxicities of Lead in Rabbits Via Anti-oxidative, Anti- Inflammatory, and Immune Stimulatory Properties. Sci Total Environ. 2020 Jan 20;701:134879. PubMed PMID: 31734488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spirulina platensis ameliorates the sub chronic toxicities of lead in rabbits via anti-oxidative, anti- inflammatory, and immune stimulatory properties. AU - Aladaileh,Saleem H, AU - Khafaga,Asmaa F, AU - Abd El-Hack,Mohamed E, AU - Al-Gabri,Naif A, AU - Abukhalil,Mohammad H, AU - Alfwuaires,Manal A, AU - Bin-Jumah,May, AU - Alkahtani,Saad, AU - Abdel-Daim,Mohamed M, AU - Aleya,Lotfi, AU - Abdelnour,Sameh, Y1 - 2019/11/01/ PY - 2019/09/11/received PY - 2019/10/05/revised PY - 2019/10/06/accepted PY - 2019/11/18/pubmed PY - 2020/1/25/medline PY - 2019/11/18/entrez KW - Antioxidant KW - Immunoglobulin KW - Lead acetate KW - NF-kB KW - Rabbits KW - Spirulina platensis SP - 134879 EP - 134879 JF - The Science of the total environment JO - Sci Total Environ VL - 701 N2 - Lead acetate (Pb) is an oldest and widespread environmental toxicant that led to cumulative injury in humans and all living organisms through induction of oxidative stress. Spirulina platensis (SP) is a cyanobacteria with strong antioxidant, anti-inflammatory, and immune stimulatory effects. In this study, the ameliorative effect of SP was evaluated against the dietary sub chronic lead toxicities in rabbits. A total number of 75 male New Zealand rabbits were allocated randomly into 5 groups; the first group feed on basal diet alone and served as control group, the second group feed on basal diet + 100 mg Pb /kg diet, the third, fourth, and the fifth groups feed on basal diet + 100 mg Pb /kg diet + SP (0.5, 1, or 1.5 g/kg diet; respectively), the experiment was extended for 8 weeks. Results revealed a significant improvement in some of growth parameters like final body weight and daily weight gain, blood parameters in rabbits treated with SP at level 1.5 g/kg diet followed by those receiving SP 1 g/kg diet. However, a significant decrease in blood parameters, liver function, renal parameters, lipid profiles, oxidative parameters (malondialdehyde and protein carbonyl), heart indices (creatine phosphokinase, creatine kinase-muscle/brain, lactate dehydrogenase), total Pb residues in muscles, and area percent of nuclear factor kappa b immune expression were reported in groups supplemented with different levels of SP. Pathologic analysis of liver, kidneys, and heart revealed moderate to severe degenerative and necrotic changes in Pb- exposed rabbits, which is ameliorated with supplementation of SP in different levels. Conclusively, dietary supplementation of SP at different levels attenuated the cumulative effect of lead in rabbits in dose-dependent manner; this attenuation may be attributed to its anti-oxidative, anti-inflammatory, as well as its immune stimulant effect. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/31734488/Spirulina_platensis_ameliorates_the_sub_chronic_toxicities_of_lead_in_rabbits_via_anti_oxidative_anti__inflammatory_and_immune_stimulatory_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)34871-5 DB - PRIME DP - Unbound Medicine ER -