Tags

Type your tag names separated by a space and hit enter

The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report.
Endocr Regul. 2019 Oct 01; 53(4):263-267.ER

Abstract

OBJECTIVES

Pituicytomas are rare, solid, well-circumscribed, low grade (grade I), non-neuroendocrine, and noninfiltrative tumors of the neurohypophysis or infundibulum, which appear in the sellar/suprasellar regions. Herein, we present a case with Cushing's disease (CD) caused by an ACTH-secreting pituitary adenoma in association with an infundibular pituicytoma. Subject and Results. A 37-year-old male patient presented to the hospital with a six-month history of blurry vision. Physical examination demonstrated plethora, excessive sweating, weight gain, moon facies, and acne. Basal serum cortisol and ACTH levels were 16 µg/dl and 32 pg/ml, respectively. The results of screening tests were suggestive of Cushing syndrome. It was also 1.97 µg/dl following 8 mg dexamethasone suppression test which was consistent with CD. Pituitary MR imaging revealed a single lesion measuring 6x6.5 mm on the pituitary stalk. Infundibular mass excision and pituitary exploration by extended endoscopic endonasal approach were applied. On immunohistochemistry, strong diffuse immunolabeling for both S100 and TTF-1 was noted for the cells of infundibular mass, diagnosed as pituicytoma. Because the developed panhypopituitarism postoperatively, patient was discharged with daily desmopressin, levothyroxine, hydrocortisone, and intramuscular testosterone, once a month.

CONCLUSIONS

Pituicytoma is an uncommon noninvasive tumor of the sellar and suprasellar regions. In this case report, we described a patient with Cushing's disease to whom MRI displayed only an infundibular well-circumscribed lesion, but not any pituitary adenoma. Despite the absence of any sellar lesion, awareness of other undetected possible lesion and exploring hypophysis during the transsphenoidal surgery is mandatory for the correct diagnosis.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.Department of Endocrinology and Metabolism, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31734654

Citation

Gezer, Emre, et al. "The Coexistence of Infundibular Pituicytoma and Cushing's Disease Due to Pituitary Adenoma: a Case Report." Endocrine Regulations, vol. 53, no. 4, 2019, pp. 263-267.
Gezer E, Selek A, Cetinarslan B, et al. The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocr Regul. 2019;53(4):263-267.
Gezer, E., Selek, A., Cetinarslan, B., Canturk, Z., Tarkun, I., & Ceylan, S. (2019). The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. Endocrine Regulations, 53(4), 263-267. https://doi.org/10.2478/enr-2019-0026
Gezer E, et al. The Coexistence of Infundibular Pituicytoma and Cushing's Disease Due to Pituitary Adenoma: a Case Report. Endocr Regul. 2019 Oct 1;53(4):263-267. PubMed PMID: 31734654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The coexistence of infundibular pituicytoma and Cushing's disease due to pituitary adenoma: A case report. AU - Gezer,Emre, AU - Selek,Alev, AU - Cetinarslan,Berrin, AU - Canturk,Zeynep, AU - Tarkun,Ilhan, AU - Ceylan,Savaş, PY - 2019/11/18/entrez PY - 2019/11/18/pubmed PY - 2020/4/15/medline KW - Cushing’s disease KW - pituicytoma SP - 263 EP - 267 JF - Endocrine regulations JO - Endocr Regul VL - 53 IS - 4 N2 - OBJECTIVES: Pituicytomas are rare, solid, well-circumscribed, low grade (grade I), non-neuroendocrine, and noninfiltrative tumors of the neurohypophysis or infundibulum, which appear in the sellar/suprasellar regions. Herein, we present a case with Cushing's disease (CD) caused by an ACTH-secreting pituitary adenoma in association with an infundibular pituicytoma. Subject and Results. A 37-year-old male patient presented to the hospital with a six-month history of blurry vision. Physical examination demonstrated plethora, excessive sweating, weight gain, moon facies, and acne. Basal serum cortisol and ACTH levels were 16 µg/dl and 32 pg/ml, respectively. The results of screening tests were suggestive of Cushing syndrome. It was also 1.97 µg/dl following 8 mg dexamethasone suppression test which was consistent with CD. Pituitary MR imaging revealed a single lesion measuring 6x6.5 mm on the pituitary stalk. Infundibular mass excision and pituitary exploration by extended endoscopic endonasal approach were applied. On immunohistochemistry, strong diffuse immunolabeling for both S100 and TTF-1 was noted for the cells of infundibular mass, diagnosed as pituicytoma. Because the developed panhypopituitarism postoperatively, patient was discharged with daily desmopressin, levothyroxine, hydrocortisone, and intramuscular testosterone, once a month. CONCLUSIONS: Pituicytoma is an uncommon noninvasive tumor of the sellar and suprasellar regions. In this case report, we described a patient with Cushing's disease to whom MRI displayed only an infundibular well-circumscribed lesion, but not any pituitary adenoma. Despite the absence of any sellar lesion, awareness of other undetected possible lesion and exploring hypophysis during the transsphenoidal surgery is mandatory for the correct diagnosis. SN - 1336-0329 UR - https://www.unboundmedicine.com/medline/citation/31734654/The_coexistence_of_infundibular_pituicytoma_and_Cushing's_disease_due_to_pituitary_adenoma:_A_case_report_ L2 - https://www.degruyter.com/document/doi/10.2478/enr-2019-0026 DB - PRIME DP - Unbound Medicine ER -