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Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma.
Dermatol Online J. 2019 Sep 15; 25(9)DO

Abstract

The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity. A 64-year-old woman presented with an eight-month history of significant weight loss, anemia, fatigue, and progressive painful cutaneous lesions on her hands, lips, back, perianal, and vulvar area that were originally treated unsuccessfully with antimalarials and systemic corticosteroids. Histopathological examination revealed an amorphous dermis with pale pink material that demonstrated positive birefringence with Congo red staining. Subsequently, the patient underwent a bone marrow biopsy, which uncovered a plasma cell myeloma, the source of her amyloidogenic protein production.

Authors+Show Affiliations

Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX. Kendra.m.walker@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31738847

Citation

Tan, Kendra W., et al. "Classic Features of Primary Systemic Amyloidosis (AL Amyloidosis) Leading to Diagnosis of Plasma Cell Myeloma." Dermatology Online Journal, vol. 25, no. 9, 2019.
Tan KW, Zhu B, Behrens E, et al. Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma. Dermatol Online J. 2019;25(9).
Tan, K. W., Zhu, B., Behrens, E., & Tarbox, M. B. (2019). Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma. Dermatology Online Journal, 25(9).
Tan KW, et al. Classic Features of Primary Systemic Amyloidosis (AL Amyloidosis) Leading to Diagnosis of Plasma Cell Myeloma. Dermatol Online J. 2019 Sep 15;25(9) PubMed PMID: 31738847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Classic features of primary systemic amyloidosis (AL amyloidosis) leading to diagnosis of plasma cell myeloma. AU - Tan,Kendra W, AU - Zhu,Brian, AU - Behrens,Emily, AU - Tarbox,Michelle B, Y1 - 2019/09/15/ PY - 2019/10/10/received PY - 2019/10/10/accepted PY - 2019/11/19/entrez PY - 2019/11/19/pubmed PY - 2020/3/31/medline JF - Dermatology online journal JO - Dermatol. Online J. VL - 25 IS - 9 N2 - The diagnosis of primary systemic amyloidosis, also known as AL (amyloid light-chain) amyloidosis, is often delayed owing to its nonspecific manifestations as well as its rarity. A 64-year-old woman presented with an eight-month history of significant weight loss, anemia, fatigue, and progressive painful cutaneous lesions on her hands, lips, back, perianal, and vulvar area that were originally treated unsuccessfully with antimalarials and systemic corticosteroids. Histopathological examination revealed an amorphous dermis with pale pink material that demonstrated positive birefringence with Congo red staining. Subsequently, the patient underwent a bone marrow biopsy, which uncovered a plasma cell myeloma, the source of her amyloidogenic protein production. SN - 1087-2108 UR - https://www.unboundmedicine.com/medline/citation/31738847/Classic_features_of_primary_systemic_amyloidosis__AL_amyloidosis__leading_to_diagnosis_of_plasma_cell_myeloma_ L2 - http://www.diseaseinfosearch.org/result/380 DB - PRIME DP - Unbound Medicine ER -