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Prevalence and associated factors of depressive symptoms among chronic kidney disease patients in China: Results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE).
J Psychosom Res. 2020 01; 128:109869.JP

Abstract

OBJECTIVE

Depression is the most common mental disorder in patients with chronic kidney disease (CKD), and previous studies have found that: (a) depression can accelerate the progression of CKD; and (b) depression is an independent risk factor for hospitalization and death among patients with CKD. Therefore, the objective of the current study was to investigate the prevalence of depression in Chinese patients with CKD, and to identify variables associated with depression.

METHODS

The study analyzed baseline data from a multicenter prospective cohort study of Chinese patients with chronic kidney disease (the C-STRIDE study). In all, 2995 participants in CKD stages 1 to 4 who completed a survey of depressive symptoms were included in the analyses. Depressive symptoms were assessed by the Zung Self-Rating Depression Scale (ZSDS). A ZSDS ≥50 was used as the cut-off score for the presence of depressive symptoms. Multivariable logistic regression was used to identify variables associated with depression.

RESULTS

The mean estimated glomerular filtration rate (eGFR) in the study sample was 51.59±29.49 ml/min/1.73 m2. The prevalence of depressive symptoms was 37.8% and increased significantly with CKD stage. Being female, a higher level of education, a low income, a larger economic impact of disease cost, comorbid cardiovascular disease, anemia, and impaired physical ability were independently associated with depressive symptoms.

CONCLUSION

Our study revealed that depressive symptoms were common among patients with CKD in China. Sociodemographic variables and the clinical characteristics of disease severity were strongly associated with depressive symptoms.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Pu L
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Zou Y
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Wu SK
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Wang F
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Zhang Y
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Li GS
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Wang JW
Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China.
Zhang LX
Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China.
Zhao MH
Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China.
Wang L
Renal Department and Institute of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: wangli@med.uestc.edu.cn.
C-STRIDE study group
No affiliation info available

MeSH

AdultAgedChinaCohort StudiesDepressionFemaleHumansMaleMiddle AgedPrevalenceProspective StudiesRenal Insufficiency, ChronicRisk Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31739085

Clinical Trial Links

Chinese Cohort Study of Chronic Kidney Disease

Citation

Pu, Lei, et al. "Prevalence and Associated Factors of Depressive Symptoms Among Chronic Kidney Disease Patients in China: Results From the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)." Journal of Psychosomatic Research, vol. 128, 2020, p. 109869.
Pu L, Zou Y, Wu SK, et al. Prevalence and associated factors of depressive symptoms among chronic kidney disease patients in China: Results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). J Psychosom Res. 2020;128:109869.
Pu, L., Zou, Y., Wu, S. K., Wang, F., Zhang, Y., Li, G. S., Wang, J. W., Zhang, L. X., Zhao, M. H., & Wang, L. (2020). Prevalence and associated factors of depressive symptoms among chronic kidney disease patients in China: Results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). Journal of Psychosomatic Research, 128, 109869. https://doi.org/10.1016/j.jpsychores.2019.109869
Pu L, et al. Prevalence and Associated Factors of Depressive Symptoms Among Chronic Kidney Disease Patients in China: Results From the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). J Psychosom Res. 2020;128:109869. PubMed PMID: 31739085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and associated factors of depressive symptoms among chronic kidney disease patients in China: Results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE). AU - Pu,Lei, AU - Zou,Yang, AU - Wu,Shu-Kun, AU - Wang,Fang, AU - Zhang,Yuan, AU - Li,Gui-Sen, AU - Wang,Jing-Wei, AU - Zhang,Lu-Xia, AU - Zhao,Ming-Hui, AU - Wang,Li, AU - ,, Y1 - 2019/11/13/ PY - 2019/06/25/received PY - 2019/11/06/revised PY - 2019/11/09/accepted PY - 2019/11/19/pubmed PY - 2020/8/5/medline PY - 2019/11/19/entrez KW - C-STRIDE study KW - Chronic kidney disease KW - Clinical epidemiology KW - Depression SP - 109869 EP - 109869 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 128 N2 - OBJECTIVE: Depression is the most common mental disorder in patients with chronic kidney disease (CKD), and previous studies have found that: (a) depression can accelerate the progression of CKD; and (b) depression is an independent risk factor for hospitalization and death among patients with CKD. Therefore, the objective of the current study was to investigate the prevalence of depression in Chinese patients with CKD, and to identify variables associated with depression. METHODS: The study analyzed baseline data from a multicenter prospective cohort study of Chinese patients with chronic kidney disease (the C-STRIDE study). In all, 2995 participants in CKD stages 1 to 4 who completed a survey of depressive symptoms were included in the analyses. Depressive symptoms were assessed by the Zung Self-Rating Depression Scale (ZSDS). A ZSDS ≥50 was used as the cut-off score for the presence of depressive symptoms. Multivariable logistic regression was used to identify variables associated with depression. RESULTS: The mean estimated glomerular filtration rate (eGFR) in the study sample was 51.59±29.49 ml/min/1.73 m2. The prevalence of depressive symptoms was 37.8% and increased significantly with CKD stage. Being female, a higher level of education, a low income, a larger economic impact of disease cost, comorbid cardiovascular disease, anemia, and impaired physical ability were independently associated with depressive symptoms. CONCLUSION: Our study revealed that depressive symptoms were common among patients with CKD in China. Sociodemographic variables and the clinical characteristics of disease severity were strongly associated with depressive symptoms. SN - 1879-1360 UR - https://www.unboundmedicine.com/medline/citation/31739085/Prevalence_and_associated_factors_of_depressive_symptoms_among_chronic_kidney_disease_patients_in_China:_Results_from_the_Chinese_Cohort_Study_of_Chronic_Kidney_Disease__C_STRIDE__ DB - PRIME DP - Unbound Medicine ER -
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