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Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice.
Biomedicine (Taipei) 2019; 9(4):25B

Abstract

BACKGROUND

This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model.

METHODS

In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies.

RESULTS

In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of Achillea wilhelmsii extract was determined ≥5000 mg/kg and that of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathological changes.

CONCLUSION

It will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants.

Authors+Show Affiliations

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.Department of Pathology, School of Veterinary Medicine, Islamic Azad University, Shahrekord, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31750830

Citation

Jafari, Mahnaz, et al. "Oral Acute and Sub-acute Toxic Effects of Hydroalcoholic Terminalia Chebula Retz and Achillea Wilhelmsii Extracts in BALB/c Mice." BioMedicine, vol. 9, no. 4, 2019, p. 25.
Jafari M, Naeini KM, Lorigooini Z, et al. Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice. Biomedicine (Taipei). 2019;9(4):25.
Jafari, M., Naeini, K. M., Lorigooini, Z., & Namjoo, R. (2019). Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice. BioMedicine, 9(4), p. 25. doi:10.1051/bmdcn/2019090425.
Jafari M, et al. Oral Acute and Sub-acute Toxic Effects of Hydroalcoholic Terminalia Chebula Retz and Achillea Wilhelmsii Extracts in BALB/c Mice. Biomedicine (Taipei). 2019;9(4):25. PubMed PMID: 31750830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral acute and sub-acute toxic effects of hydroalcoholic Terminalia chebula Retz and Achillea wilhelmsii extracts in BALB/c mice. AU - Jafari,Mahnaz, AU - Naeini,Kourosh Manochehri, AU - Lorigooini,Zahra, AU - Namjoo,Rasool, Y1 - 2019/11/21/ PY - 2019/07/08/received PY - 2019/07/22/accepted PY - 2019/11/22/entrez PY - 2019/11/22/pubmed PY - 2019/11/22/medline KW - Achillea wilhelmsii KW - Acute toxicity KW - Animal Model KW - Sub-acute toxicity KW - Terminalia chebula SP - 25 EP - 25 JF - BioMedicine JO - Biomedicine (Taipei) VL - 9 IS - 4 N2 - BACKGROUND: This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model. METHODS: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies. RESULTS: In the acute phase of the study, the safe dose was ≤5000 mg/kg for both extracts. In sub-acute phase, LD50 (95% CI) of Achillea wilhelmsii extract was determined ≥5000 mg/kg and that of Terminalia chebula extract 2754.436 (2438-3114) mg/kg. The highest dose of T. chebula extract induced few histopathological changes. CONCLUSION: It will be useful to gain information on the minimum lethal doses of T. chebula and A. wilhelmsii to adopt safe doses of the two plants. SN - 2211-8020 UR - https://www.unboundmedicine.com/medline/citation/31750830/Oral_acute_and_sub-acute_toxic_effects_of_hydroalcoholic_Terminalia_chebula_Retz_and_Achillea_wilhelmsii_extracts_in_BALB/c_mice L2 - http://publications.edpsciences.org/10.1051/bmdcn/2019090425 DB - PRIME DP - Unbound Medicine ER -