Tags

Type your tag names separated by a space and hit enter

Characterization of proanthocyanidin-chitosan interactions in the formulation of composite nanoparticles using surface plasmon resonance.
Int J Biol Macromol. 2020 Jun 01; 152:1068-1076.IJ

Abstract

Chitosan (CHT) interacts with proanthocyanidins (PAC) by a mechanism involving hydrogen bonding and ion-dipole interactions, allowing the spontaneous formation of PAC-CHT composite nanoparticles (PAC-CHT NPs). The interaction between PAC and CHT was characterized by ellipsometry, infrared spectroscopy, and surface plasmon resonance (SPR) to determine the effect of CHT molecular weight (MW), PAC to CHT ratios, and pH on the formulation of PAC-CHT NPs. These parameters also affect the size and morphology of PAC-CHT NPs. Results indicate that CHT MW and pH of the solution impact the interactions of PAC-CHT in two ways: (1) greater CHT MW increases the amount of PAC molecules that attach to the CHT chain, and (2) lower pH of the CHT solutions increases the amount PAC molecules that attach to the CHT chain. Results also show that higher CHT MW, CHT concentration, and pH of the CHT solutions increase the size of PAC-CHT NPs. In contrast, greater PAC concentrations decreases the size of PAC-CHT NPs. This study demonstrates that SPR is a useful technique for measuring the effect of changes in the interaction between PAC and CHT, which in turn affects the size and morphology of PAC-CHT NPs.

Authors+Show Affiliations

Material Sciences & Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, United States; Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States. Electronic address: alfaroviquez@wisc.edu.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.Material Sciences & Engineering, University of Wisconsin-Madison, 1415 Engineering Dr, Madison, WI 53706, United States; Reed Research Group, Department of Animal Science, University of Wisconsin-Madison, 1675 Observatory Dr, Madison, WI 53706, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31751745

Citation

Alfaro-Viquez, Emilia, et al. "Characterization of Proanthocyanidin-chitosan Interactions in the Formulation of Composite Nanoparticles Using Surface Plasmon Resonance." International Journal of Biological Macromolecules, vol. 152, 2020, pp. 1068-1076.
Alfaro-Viquez E, Esquivel-Alvarado D, Madrigal-Carballo S, et al. Characterization of proanthocyanidin-chitosan interactions in the formulation of composite nanoparticles using surface plasmon resonance. Int J Biol Macromol. 2020;152:1068-1076.
Alfaro-Viquez, E., Esquivel-Alvarado, D., Madrigal-Carballo, S., Krueger, C. G., & Reed, J. D. (2020). Characterization of proanthocyanidin-chitosan interactions in the formulation of composite nanoparticles using surface plasmon resonance. International Journal of Biological Macromolecules, 152, 1068-1076. https://doi.org/10.1016/j.ijbiomac.2019.10.194
Alfaro-Viquez E, et al. Characterization of Proanthocyanidin-chitosan Interactions in the Formulation of Composite Nanoparticles Using Surface Plasmon Resonance. Int J Biol Macromol. 2020 Jun 1;152:1068-1076. PubMed PMID: 31751745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of proanthocyanidin-chitosan interactions in the formulation of composite nanoparticles using surface plasmon resonance. AU - Alfaro-Viquez,Emilia, AU - Esquivel-Alvarado,Daniel, AU - Madrigal-Carballo,Sergio, AU - Krueger,Christian G, AU - Reed,Jess D, Y1 - 2019/11/18/ PY - 2019/09/16/received PY - 2019/10/15/revised PY - 2019/10/19/accepted PY - 2019/11/22/pubmed PY - 2019/11/22/medline PY - 2019/11/22/entrez KW - Chitosan KW - Interaction KW - Proanthocyanidin KW - Proanthocyanidin-chitosan composite nanoparticles KW - Surface plasmon resonance SP - 1068 EP - 1076 JF - International journal of biological macromolecules JO - Int. J. Biol. Macromol. VL - 152 N2 - Chitosan (CHT) interacts with proanthocyanidins (PAC) by a mechanism involving hydrogen bonding and ion-dipole interactions, allowing the spontaneous formation of PAC-CHT composite nanoparticles (PAC-CHT NPs). The interaction between PAC and CHT was characterized by ellipsometry, infrared spectroscopy, and surface plasmon resonance (SPR) to determine the effect of CHT molecular weight (MW), PAC to CHT ratios, and pH on the formulation of PAC-CHT NPs. These parameters also affect the size and morphology of PAC-CHT NPs. Results indicate that CHT MW and pH of the solution impact the interactions of PAC-CHT in two ways: (1) greater CHT MW increases the amount of PAC molecules that attach to the CHT chain, and (2) lower pH of the CHT solutions increases the amount PAC molecules that attach to the CHT chain. Results also show that higher CHT MW, CHT concentration, and pH of the CHT solutions increase the size of PAC-CHT NPs. In contrast, greater PAC concentrations decreases the size of PAC-CHT NPs. This study demonstrates that SPR is a useful technique for measuring the effect of changes in the interaction between PAC and CHT, which in turn affects the size and morphology of PAC-CHT NPs. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/31751745/Characterization_of_proanthocyanidin_chitosan_interactions_in_the_formulation_of_composite_nanoparticles_using_surface_plasmon_resonance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(19)37529-4 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.