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Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis.
Parasite. 2019; 26:68.P

Abstract

The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

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Authors+Show Affiliations

Dama E
Centre International de Recherche-Développement sur l'Elevage en zones Subhumides (CIRDES), Unité de recherches sur les maladies à vecteurs et biodiversité, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso - Université Nazi Boni, Bobo-Dioulasso, 01 BP 1091 Bobo-Dioulasso, Burkina Faso.
Camara O
Programme National de Lutte contre la Trypanosomose Humaine Africaine, BP 851, Conakry, Guinée.
Kaba D
Institut Pierre Richet, Unité de Recherche « Trypanosomoses », 01 BP 1500, Bouaké, Côte d'Ivoire.
Koffi M
Université Jean Lorougnon Guédé, Laboratoire de biodiversité et Gestion durable des écosystèmes tropicaux, Unité de Recherche en Génétique et Epidémiologie moléculaire, BP 150 Daloa, Côte d'Ivoire.
Camara M
Programme National de Lutte contre la Trypanosomose Humaine Africaine, BP 851, Conakry, Guinée.
Compaoré C
Centre International de Recherche-Développement sur l'Elevage en zones Subhumides (CIRDES), Unité de recherches sur les maladies à vecteurs et biodiversité, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso.
Ilboudo H
Institut de Recherche en Sciences de la Santé (IRSS), Unité de Recherche Clinique de Nanoro (URCN), 11 BP 218 Ouagadougou CMS 11, Burkina Faso.
Courtin F
Institut Pierre Richet, Unité de Recherche « Trypanosomoses », 01 BP 1500, Bouaké, Côte d'Ivoire - Institut de Recherche pour le Développement (IRD), UMR INTERTRYP IRD-CIRAD, Université de Montpellier, TA A-17/G, Campus International de Baillarguet, F-34398 Montpellier, France.
Kaboré J
Centre International de Recherche-Développement sur l'Elevage en zones Subhumides (CIRDES), Unité de recherches sur les maladies à vecteurs et biodiversité, 01 BP 454 Bobo-Dioulasso 01, Burkina Faso - Université Nazi Boni, Bobo-Dioulasso, 01 BP 1091 Bobo-Dioulasso, Burkina Faso.
N'Gouan EK
Projet de Recherche Clinique sur les Trypanosomoses, BP 1425, Daloa, Côte d'Ivoire.
Büscher P
Institute of Tropical Medicine, Department of Biomedical Sciences, Nationalestraat 155, 2000 Antwerp, Belgium.
Lejon V
Institut de Recherche pour le Développement (IRD), UMR INTERTRYP IRD-CIRAD, Université de Montpellier, TA A-17/G, Campus International de Baillarguet, F-34398 Montpellier, France.
Bucheton B
Programme National de Lutte contre la Trypanosomose Humaine Africaine, BP 851, Conakry, Guinée - Institut de Recherche pour le Développement (IRD), UMR INTERTRYP IRD-CIRAD, Université de Montpellier, TA A-17/G, Campus International de Baillarguet, F-34398 Montpellier, France.
Jamonneau V
Institut Pierre Richet, Unité de Recherche « Trypanosomoses », 01 BP 1500, Bouaké, Côte d'Ivoire - Institut de Recherche pour le Développement (IRD), UMR INTERTRYP IRD-CIRAD, Université de Montpellier, TA A-17/G, Campus International de Baillarguet, F-34398 Montpellier, France.

MeSH

Africa, WesternBiological AssayCytotoxicity Tests, ImmunologicDisease EradicationHumansTrypanosoma brucei gambienseTrypanosomiasis, African

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31755862

Citation

Dama, Emilie, et al. "Immune Trypanolysis Test as a Promising Bioassay to Monitor the Elimination of Gambiense Human African Trypanosomiasis." Parasite (Paris, France), vol. 26, 2019, p. 68.
Dama E, Camara O, Kaba D, et al. Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis. Parasite. 2019;26:68.
Dama, E., Camara, O., Kaba, D., Koffi, M., Camara, M., Compaoré, C., Ilboudo, H., Courtin, F., Kaboré, J., N'Gouan, E. K., Büscher, P., Lejon, V., Bucheton, B., & Jamonneau, V. (2019). Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis. Parasite (Paris, France), 26, 68. https://doi.org/10.1051/parasite/2019066
Dama E, et al. Immune Trypanolysis Test as a Promising Bioassay to Monitor the Elimination of Gambiense Human African Trypanosomiasis. Parasite. 2019;26:68. PubMed PMID: 31755862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis. AU - Dama,Emilie, AU - Camara,Oumou, AU - Kaba,Dramane, AU - Koffi,Mathurin, AU - Camara,Mamadou, AU - Compaoré,Charlie, AU - Ilboudo,Hamidou, AU - Courtin,Fabrice, AU - Kaboré,Jacques, AU - N'Gouan,Emmanuel Kouassi, AU - Büscher,Philippe, AU - Lejon,Veerle, AU - Bucheton,Bruno, AU - Jamonneau,Vincent, Y1 - 2019/11/22/ PY - 2019/04/10/received PY - 2019/10/30/accepted PY - 2019/11/23/entrez PY - 2019/11/23/pubmed PY - 2020/5/10/medline KW - Diagnosis KW - Elimination KW - Human African Trypanosomiasis KW - Immune trypanolysis KW - Transmission KW - Trypanosoma brucei gambiense SP - 68 EP - 68 JF - Parasite (Paris, France) JO - Parasite VL - 26 N2 - The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area. SN - 1776-1042 UR - https://www.unboundmedicine.com/medline/citation/31755862/Immune_trypanolysis_test_as_a_promising_bioassay_to_monitor_the_elimination_of_gambiense_human_African_trypanosomiasis_ DB - PRIME DP - Unbound Medicine ER -