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Do predictive environmentally relevant concentrations of ZnO nanoparticles induce antipredator behavioral response deficit in Swiss mice?
Sci Total Environ. 2020 Feb 10; 703:135486.ST

Abstract

The toxicity of zinc oxide nanoparticles (ZnO NPs) has been addressed in several studies; however, their effect on the mammalian group, even at environmentally relevant concentrations, remains poorly understood. The aims of the present study are to expose female Swiss mice to ZnO NP concentrations commonly faced by mammals who enter aquatic systems to perform different ecological functions and to assess the possible effects of such particles on their behavior. The test animals were placed in water added with ZnO NPs for 3 min, 2 times/day, for 21 days. Two experimental groups were set, NP1x, composed of animals subjected to ZnO NP concentration of 760 μg/L; and NP50x (control), which encompassed animals subjected to 38,000 μg/L. Based on field test results (OF), the contact with NPs did not induce locomotor deficits or anxiogenic and anxiolytic effect on the animal models. However, models exposed to NPs were not able to recognize the predatory threat posed by the presence of Pantherophis guttatus and Arapaima gigas; on the other hand, animals in the control group, who were not exposed to ZnO NPs, did not present antipredator behavioral response deficit. Furthermore, mice exposed to NPs were unable to distinguish real predators from plastic copies, and it suggests antipredator behavioral response deficit. High Zn concentrations in blood, liver, brain and skin samples are associated with deficit caused by the exposure to ZnO NPs. To the best of our knowledge, the current study is in the first to evidence that ZnO NPs induce changes in antipredator behavioral responses, even under ephemeral conditions and at low concentrations. However, the exposure to ZnO NPs can be a risk to the health of the assessed individuals and to the dynamics of their populations if the present antipredator behavioral response test results are extrapolated to the ecological context.

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Authors+Show Affiliations

da Luz TM
Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil.
Freitas ÍN
Goiano Federal Institute - Rectory, GO, Brazil.
Silva FG
Post-graduation Program in Cerrado Natural Resource Conservation and Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil.
da Costa Araújo AP
Post-graduation Program in Cerrado Natural Resource Conservation and Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil.
Fernandes T
Laboratory of Electron Microscopy and Microanalysis (L.E.M.M.) of Londrina State University, PR, Brazil.
Rodrigues FP
Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil.
de Oliveira Junior AG
Laboratory of Electron Microscopy and Microanalysis (L.E.M.M.) of Londrina State University, PR, Brazil.
Malafaia G
Biological Research Laboratory, Goiano Federal Institute - Urutaí Campus, GO, Brazil; Goiano Federal Institute - Rectory, GO, Brazil. Electronic address: guilhermeifgoiano@gmail.com.

MeSH

AnimalsBehavior, AnimalMetal NanoparticlesMiceToxicity TestsWater Pollutants, ChemicalZinc Oxide

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31757542

Citation

da Luz, Thiarlen Marinho, et al. "Do Predictive Environmentally Relevant Concentrations of ZnO Nanoparticles Induce Antipredator Behavioral Response Deficit in Swiss Mice?" The Science of the Total Environment, vol. 703, 2020, p. 135486.
da Luz TM, Freitas ÍN, Silva FG, et al. Do predictive environmentally relevant concentrations of ZnO nanoparticles induce antipredator behavioral response deficit in Swiss mice? Sci Total Environ. 2020;703:135486.
da Luz, T. M., Freitas, Í. N., Silva, F. G., da Costa Araújo, A. P., Fernandes, T., Rodrigues, F. P., de Oliveira Junior, A. G., & Malafaia, G. (2020). Do predictive environmentally relevant concentrations of ZnO nanoparticles induce antipredator behavioral response deficit in Swiss mice? The Science of the Total Environment, 703, 135486. https://doi.org/10.1016/j.scitotenv.2019.135486
da Luz TM, et al. Do Predictive Environmentally Relevant Concentrations of ZnO Nanoparticles Induce Antipredator Behavioral Response Deficit in Swiss Mice. Sci Total Environ. 2020 Feb 10;703:135486. PubMed PMID: 31757542.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do predictive environmentally relevant concentrations of ZnO nanoparticles induce antipredator behavioral response deficit in Swiss mice? AU - da Luz,Thiarlen Marinho, AU - Freitas,Ítalo Nascimento, AU - Silva,Fabiano Guimarães, AU - da Costa Araújo,Amanda Pereira, AU - Fernandes,Thiago, AU - Rodrigues,Fernando Postalli, AU - de Oliveira Junior,Admilton Gonçalves, AU - Malafaia,Guilherme, Y1 - 2019/11/14/ PY - 2019/05/23/received PY - 2019/11/09/revised PY - 2019/11/10/accepted PY - 2019/11/24/pubmed PY - 2020/3/7/medline PY - 2019/11/24/entrez KW - Environmental concentrations KW - Environmental toxicology KW - Freshwater KW - Mammals KW - Nanotoxicology SP - 135486 EP - 135486 JF - The Science of the total environment JO - Sci Total Environ VL - 703 N2 - The toxicity of zinc oxide nanoparticles (ZnO NPs) has been addressed in several studies; however, their effect on the mammalian group, even at environmentally relevant concentrations, remains poorly understood. The aims of the present study are to expose female Swiss mice to ZnO NP concentrations commonly faced by mammals who enter aquatic systems to perform different ecological functions and to assess the possible effects of such particles on their behavior. The test animals were placed in water added with ZnO NPs for 3 min, 2 times/day, for 21 days. Two experimental groups were set, NP1x, composed of animals subjected to ZnO NP concentration of 760 μg/L; and NP50x (control), which encompassed animals subjected to 38,000 μg/L. Based on field test results (OF), the contact with NPs did not induce locomotor deficits or anxiogenic and anxiolytic effect on the animal models. However, models exposed to NPs were not able to recognize the predatory threat posed by the presence of Pantherophis guttatus and Arapaima gigas; on the other hand, animals in the control group, who were not exposed to ZnO NPs, did not present antipredator behavioral response deficit. Furthermore, mice exposed to NPs were unable to distinguish real predators from plastic copies, and it suggests antipredator behavioral response deficit. High Zn concentrations in blood, liver, brain and skin samples are associated with deficit caused by the exposure to ZnO NPs. To the best of our knowledge, the current study is in the first to evidence that ZnO NPs induce changes in antipredator behavioral responses, even under ephemeral conditions and at low concentrations. However, the exposure to ZnO NPs can be a risk to the health of the assessed individuals and to the dynamics of their populations if the present antipredator behavioral response test results are extrapolated to the ecological context. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/31757542/Do_predictive_environmentally_relevant_concentrations_of_ZnO_nanoparticles_induce_antipredator_behavioral_response_deficit_in_Swiss_mice DB - PRIME DP - Unbound Medicine ER -