Tags

Type your tag names separated by a space and hit enter

Shen-Ling-Bai-Zhu-San alleviates functional dyspepsia in rats and modulates the composition of the gut microbiota.
Nutr Res. 2019 11; 71:89-99.NR

Abstract

The pathogenesis of functional dyspepsia (FD) is multifactorial, and the gut microbiota may play a significant role. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional Chinese herbal medicine, has been widely used in the treatment of FD, and appears to influence the gut microbiota. Therefore, we hypothesized that SLBZS would alleviate dyspeptic symptoms by adjusting the composition of the gut microbiota. To test this hypothesis, we aimed to evaluate the effects of SLBZS on FD and elucidate the mechanism that underlies the interactions between gut microbiota and FD during SLBZS treatment. We employed a rat model of FD induced by multiple forms of chronic mild stimulation. 16S rRNA gene sequencing and shotgun metagenomic sequencing were used to analyze the microbial communities in fecal samples from the rats. We found that the SLBZS improved dyspeptic symptoms in FD rats, such as weight loss, decreased intestinal motility, reduced absorptive capacity. Moreover, the SLBZS treatment reversed gut dysbiosis in FD. With SLBZS treatment, FD biomarkers including Prevotella, Mucispirillum and Akkermansia were decreased while SCFA-producing bacteria such as Adlercreutzia and Clostridium, and sulfate-reducing bacteria Desulfovibrio were enriched. Additionally, SLBZS normalized the dysregulated function of the microbiome, upregulating the pathways of energy metabolism and decreasing the oxidative stress as well as bacterial pathogenesis. Our study demonstrated that SLBZS could ameliorate dyspepsia, and amend the dysregulated composition and function of the gut microbial community, providing insight into the mechanism of SLBZS treatment for FD from the perspective of gut microbiota.

Authors+Show Affiliations

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China; Key Laboratory of State Administration of Traditional Chinese Medicine, Sunshine Lake Pharma Company Ltd, Dongguan, 523867, China.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, 510006, China. Electronic address: xiezhy@mail.sysu.edu.cn.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31757632

Citation

Zhang, Shaobao, et al. "Shen-Ling-Bai-Zhu-San Alleviates Functional Dyspepsia in Rats and Modulates the Composition of the Gut Microbiota." Nutrition Research (New York, N.Y.), vol. 71, 2019, pp. 89-99.
Zhang S, Lin L, Liu W, et al. Shen-Ling-Bai-Zhu-San alleviates functional dyspepsia in rats and modulates the composition of the gut microbiota. Nutr Res. 2019;71:89-99.
Zhang, S., Lin, L., Liu, W., Zou, B., Cai, Y., Liu, D., Xiao, D., Chen, J., Li, P., Zhong, Y., Liao, Q., & Xie, Z. (2019). Shen-Ling-Bai-Zhu-San alleviates functional dyspepsia in rats and modulates the composition of the gut microbiota. Nutrition Research (New York, N.Y.), 71, 89-99. https://doi.org/10.1016/j.nutres.2019.10.001
Zhang S, et al. Shen-Ling-Bai-Zhu-San Alleviates Functional Dyspepsia in Rats and Modulates the Composition of the Gut Microbiota. Nutr Res. 2019;71:89-99. PubMed PMID: 31757632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shen-Ling-Bai-Zhu-San alleviates functional dyspepsia in rats and modulates the composition of the gut microbiota. AU - Zhang,Shaobao, AU - Lin,Lei, AU - Liu,Wen, AU - Zou,Baorong, AU - Cai,Ying, AU - Liu,Deliang, AU - Xiao,Dan, AU - Chen,Jiahui, AU - Li,Pei, AU - Zhong,Yuping, AU - Liao,Qiongfeng, AU - Xie,Zhiyong, Y1 - 2019/10/29/ PY - 2019/02/19/received PY - 2019/10/04/revised PY - 2019/10/10/accepted PY - 2019/11/24/pubmed PY - 2019/11/24/medline PY - 2019/11/24/entrez KW - 16S gene sequencing KW - Shen-Ling-Bai-Zhu-San KW - functional dyspepsia KW - gut microbiota KW - metagenomics SP - 89 EP - 99 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 71 N2 - The pathogenesis of functional dyspepsia (FD) is multifactorial, and the gut microbiota may play a significant role. Shen-Ling-Bai-Zhu-San (SLBZS), a traditional Chinese herbal medicine, has been widely used in the treatment of FD, and appears to influence the gut microbiota. Therefore, we hypothesized that SLBZS would alleviate dyspeptic symptoms by adjusting the composition of the gut microbiota. To test this hypothesis, we aimed to evaluate the effects of SLBZS on FD and elucidate the mechanism that underlies the interactions between gut microbiota and FD during SLBZS treatment. We employed a rat model of FD induced by multiple forms of chronic mild stimulation. 16S rRNA gene sequencing and shotgun metagenomic sequencing were used to analyze the microbial communities in fecal samples from the rats. We found that the SLBZS improved dyspeptic symptoms in FD rats, such as weight loss, decreased intestinal motility, reduced absorptive capacity. Moreover, the SLBZS treatment reversed gut dysbiosis in FD. With SLBZS treatment, FD biomarkers including Prevotella, Mucispirillum and Akkermansia were decreased while SCFA-producing bacteria such as Adlercreutzia and Clostridium, and sulfate-reducing bacteria Desulfovibrio were enriched. Additionally, SLBZS normalized the dysregulated function of the microbiome, upregulating the pathways of energy metabolism and decreasing the oxidative stress as well as bacterial pathogenesis. Our study demonstrated that SLBZS could ameliorate dyspepsia, and amend the dysregulated composition and function of the gut microbial community, providing insight into the mechanism of SLBZS treatment for FD from the perspective of gut microbiota. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/31757632/Shen_Ling_Bai_Zhu_San_alleviates_functional_dyspepsia_in_rats_and_modulates_the_composition_of_the_gut_microbiota_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(19)30189-7 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.