Tags

Type your tag names separated by a space and hit enter

Biosynthesis of silver nanoparticles using leaf extract of Aesculus hippocastanum (horse chestnut): Evaluation of their antibacterial, antioxidant and drug release system activities.
Mater Sci Eng C Mater Biol Appl. 2020 Feb; 107:110207.MS

Abstract

Biosynthesis of metal nanoparticles is expected as a cost efficient and ecofriendly option in the research study. Therefore, the aqueous extracts made from leaf of Aesculus hippocastanum (horse chestnut) were used as the reducing factors to synthesize silver nanoparticles (AgNPs) and their antioxidant, antibacterial and the application of resveratrol combined AgNPs as efficient delivery vehicles have also been evaluated. The biosynthesized AgNPs were characterized by UV-Visible Spectroscopy, Fourier-Transform Infrared Spectroscopy (FTIR), X Ray Diffraction (XRD), Zeta potential, and Scanning Electron Microscopy (SEM). The AgNPs were found to be stable at -29.1 mV through zeta potential study. According to the UV-Vis measurements, AgNP formation was observed at a wavelength range of 420-470 nm. The Ag NPs were spherical with a size of 50 ± 5 nm. AgNPs exhibited strong antibacterial activity against all tested bacterial species but have no effect against fungal strains. AgNPs showed an important inhibitive activity counter the DPPH radical and thereby indicate a source for antioxidants. The free radical scavenging activity of AgNP was calculated as 54.72% at the highest concentration (100 ppm). The superoxide radical scavenging activity of AgNPs was found to be increased with increasing concentrations and the average inhibition was about 62.9% as compared to the activity of plant extract. In vitro investigations on the drug delivery from AgNPs exhibited pH dependency; the release was significant (45.6%) below acidic terms (pH 5.2) when in proportion to physiological terms (pH7.4). It was observed that the resveratrol-combined to AgNPs stays on the nanoparticle surface for a lengthy time in the plasma at physiological pH (7.4), so very reducing the flank influence on the normal tissues. It can be concluded that horse chestnut leaves has reduction potential as well as being a capping agent to produce well-defined nanoscale silver particles. Our biosynthesized Ag NPs can be used antibacterial, antioxidant agent and also for as effective delivery vehicles in the near future.

Authors+Show Affiliations

Erciyes University, Science Faculty, Biology Department, Kayseri, Turkey. Electronic address: fozturk@erciyes.edu.tr.Erciyes University, Graduate School of Natural and Applied Sciences, Kayseri, Turkey.Erciyes University, Science Faculty, Biology Department, Kayseri, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31761206

Citation

Küp, Fatma Öztürk, et al. "Biosynthesis of Silver Nanoparticles Using Leaf Extract of Aesculus Hippocastanum (horse Chestnut): Evaluation of Their Antibacterial, Antioxidant and Drug Release System Activities." Materials Science & Engineering. C, Materials for Biological Applications, vol. 107, 2020, p. 110207.
Küp FÖ, Çoşkunçay S, Duman F. Biosynthesis of silver nanoparticles using leaf extract of Aesculus hippocastanum (horse chestnut): Evaluation of their antibacterial, antioxidant and drug release system activities. Mater Sci Eng C Mater Biol Appl. 2020;107:110207.
Küp, F. Ö., Çoşkunçay, S., & Duman, F. (2020). Biosynthesis of silver nanoparticles using leaf extract of Aesculus hippocastanum (horse chestnut): Evaluation of their antibacterial, antioxidant and drug release system activities. Materials Science & Engineering. C, Materials for Biological Applications, 107, 110207. https://doi.org/10.1016/j.msec.2019.110207
Küp FÖ, Çoşkunçay S, Duman F. Biosynthesis of Silver Nanoparticles Using Leaf Extract of Aesculus Hippocastanum (horse Chestnut): Evaluation of Their Antibacterial, Antioxidant and Drug Release System Activities. Mater Sci Eng C Mater Biol Appl. 2020;107:110207. PubMed PMID: 31761206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biosynthesis of silver nanoparticles using leaf extract of Aesculus hippocastanum (horse chestnut): Evaluation of their antibacterial, antioxidant and drug release system activities. AU - Küp,Fatma Öztürk, AU - Çoşkunçay,Seval, AU - Duman,Fatih, Y1 - 2019/10/30/ PY - 2017/11/15/received PY - 2019/09/04/revised PY - 2019/09/13/accepted PY - 2019/11/26/entrez PY - 2019/11/26/pubmed PY - 2020/4/16/medline KW - Antibacterial activity KW - Antioxidant activity KW - Drug delivery system KW - Green synthesis KW - Horse chestnut KW - Silver nanoparticle SP - 110207 EP - 110207 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 107 N2 - Biosynthesis of metal nanoparticles is expected as a cost efficient and ecofriendly option in the research study. Therefore, the aqueous extracts made from leaf of Aesculus hippocastanum (horse chestnut) were used as the reducing factors to synthesize silver nanoparticles (AgNPs) and their antioxidant, antibacterial and the application of resveratrol combined AgNPs as efficient delivery vehicles have also been evaluated. The biosynthesized AgNPs were characterized by UV-Visible Spectroscopy, Fourier-Transform Infrared Spectroscopy (FTIR), X Ray Diffraction (XRD), Zeta potential, and Scanning Electron Microscopy (SEM). The AgNPs were found to be stable at -29.1 mV through zeta potential study. According to the UV-Vis measurements, AgNP formation was observed at a wavelength range of 420-470 nm. The Ag NPs were spherical with a size of 50 ± 5 nm. AgNPs exhibited strong antibacterial activity against all tested bacterial species but have no effect against fungal strains. AgNPs showed an important inhibitive activity counter the DPPH radical and thereby indicate a source for antioxidants. The free radical scavenging activity of AgNP was calculated as 54.72% at the highest concentration (100 ppm). The superoxide radical scavenging activity of AgNPs was found to be increased with increasing concentrations and the average inhibition was about 62.9% as compared to the activity of plant extract. In vitro investigations on the drug delivery from AgNPs exhibited pH dependency; the release was significant (45.6%) below acidic terms (pH 5.2) when in proportion to physiological terms (pH7.4). It was observed that the resveratrol-combined to AgNPs stays on the nanoparticle surface for a lengthy time in the plasma at physiological pH (7.4), so very reducing the flank influence on the normal tissues. It can be concluded that horse chestnut leaves has reduction potential as well as being a capping agent to produce well-defined nanoscale silver particles. Our biosynthesized Ag NPs can be used antibacterial, antioxidant agent and also for as effective delivery vehicles in the near future. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/31761206/Biosynthesis_of_silver_nanoparticles_using_leaf_extract_of_Aesculus_hippocastanum__horse_chestnut_:_Evaluation_of_their_antibacterial_antioxidant_and_drug_release_system_activities_ DB - PRIME DP - Unbound Medicine ER -