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Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1.
Biomed Pharmacother. 2020 Jan; 121:109668.BP

Abstract

Velvet antler is one of the most important animal medicines or functional foods widely used in East Asia for many centuries, which has several biological activities including anti-ageing and health promotion. To date, the mechanism underlying these effects of velvet antler is widely studied by its protein or polypeptide components. Few studies have been reported for the function of the other components in velvet antler. Herein, C. elegans is used as the model animal to dissect how none protein components of velvet antler affect in vivo oxidative stress. Methanol extracts (MEs) from velvet antler which has few protein components extends the maximum lifespan of C. elegans compared to the control under oxidative stress, while water extracts (WEs) which is protein-rich component has no apparent function. The activity of MEs is mediated by clk-1 signaling pathway, but not via daf-2, eat-2 or glp-1 pathway. Further investigations show MEs decrease endogenous ROS by promoting SKN-1 nuclei translocation, subsequently up-regulating the expression of its target genes gst-4, gst-7 and gst-10 in C. elegans. In all, MEs, the none protein components of velvet antler, protects against oxidative stress in C. elegans, which indicates it might be a product with potential of being a curative medicine.

Authors+Show Affiliations

Department of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.Key Laboratory of Special Animal Molecular Biology of Jilin Province, Specialty Research Institute of Chinese Academy of Agricultural Sciences, Changchun, Jilin 130112, China.Department of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, China.Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.Key Laboratory of Special Animal Molecular Biology of Jilin Province, Specialty Research Institute of Chinese Academy of Agricultural Sciences, Changchun, Jilin 130112, China.Department of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, China.Key Laboratory of Special Animal Molecular Biology of Jilin Province, Specialty Research Institute of Chinese Academy of Agricultural Sciences, Changchun, Jilin 130112, China. Electronic address: yinghua.peng@ciac.ac.cn.College of Marine Science and Biological Engineering, Qingdao University of Science & Technology, Qingdao, 266042, China; College of Agriculture, Yanbian University, Yanji, 133002, China. Electronic address: guozhijunvip@163.com.State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China; Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; Department of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, China. Electronic address: xiaohui.wang@ciac.ac.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31766103

Citation

Wang, Xue, et al. "Velvet Antler Methanol Extracts (MEs) Protects Against Oxidative Stress in Caenorhabditis Elegans By SKN-1." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 121, 2020, p. 109668.
Wang X, Li H, Liu Y, et al. Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1. Biomed Pharmacother. 2020;121:109668.
Wang, X., Li, H., Liu, Y., Wu, H., Wang, H., Jin, S., Lu, Y., Chang, S., Liu, R., Peng, Y., Guo, Z., & Wang, X. (2020). Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 121, 109668. https://doi.org/10.1016/j.biopha.2019.109668
Wang X, et al. Velvet Antler Methanol Extracts (MEs) Protects Against Oxidative Stress in Caenorhabditis Elegans By SKN-1. Biomed Pharmacother. 2020;121:109668. PubMed PMID: 31766103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Velvet antler methanol extracts (MEs) protects against oxidative stress in Caenorhabditis elegans by SKN-1. AU - Wang,Xue, AU - Li,Hongyuan, AU - Liu,Ying, AU - Wu,Hua, AU - Wang,Hongshuang, AU - Jin,Sha, AU - Lu,Yuyuan, AU - Chang,Shuzhuo, AU - Liu,Renjie, AU - Peng,Yinghua, AU - Guo,Zhijun, AU - Wang,Xiaohui, Y1 - 2019/11/19/ PY - 2019/08/28/received PY - 2019/09/30/revised PY - 2019/10/14/accepted PY - 2019/11/27/pubmed PY - 2020/6/4/medline PY - 2019/11/27/entrez KW - Caenorhabditis elegans KW - Oxidative stress KW - Reactive oxygen species KW - Velvet antler SP - 109668 EP - 109668 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed. Pharmacother. VL - 121 N2 - Velvet antler is one of the most important animal medicines or functional foods widely used in East Asia for many centuries, which has several biological activities including anti-ageing and health promotion. To date, the mechanism underlying these effects of velvet antler is widely studied by its protein or polypeptide components. Few studies have been reported for the function of the other components in velvet antler. Herein, C. elegans is used as the model animal to dissect how none protein components of velvet antler affect in vivo oxidative stress. Methanol extracts (MEs) from velvet antler which has few protein components extends the maximum lifespan of C. elegans compared to the control under oxidative stress, while water extracts (WEs) which is protein-rich component has no apparent function. The activity of MEs is mediated by clk-1 signaling pathway, but not via daf-2, eat-2 or glp-1 pathway. Further investigations show MEs decrease endogenous ROS by promoting SKN-1 nuclei translocation, subsequently up-regulating the expression of its target genes gst-4, gst-7 and gst-10 in C. elegans. In all, MEs, the none protein components of velvet antler, protects against oxidative stress in C. elegans, which indicates it might be a product with potential of being a curative medicine. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/31766103/Velvet_antler_methanol_extracts__MEs__protects_against_oxidative_stress_in_Caenorhabditis_elegans_by_SKN_1_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(19)35290-4 DB - PRIME DP - Unbound Medicine ER -