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Mitochondrial MiRNA in Cardiovascular Function and Disease.
Cells. 2019 11 21; 8(12)C

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs functioning as crucial post-transcriptional regulators of gene expression involved in cardiovascular development and health. Recently, mitochondrial miRNAs (mitomiRs) have been shown to modulate the translational activity of the mitochondrial genome and regulating mitochondrial protein expression and function. Although mitochondria have been verified to be essential for the development and as a therapeutic target for cardiovascular diseases, we are just beginning to understand the roles of mitomiRs in the regulation of crucial biological processes, including energy metabolism, oxidative stress, inflammation, and apoptosis. In this review, we summarize recent findings regarding how mitomiRs impact on mitochondrial gene expression and mitochondrial function, which may help us better understand the contribution of mitomiRs to both the regulation of cardiovascular function under physiological conditions and the pathogenesis of cardiovascular diseases.

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Authors+Show Affiliations

Song R
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Hu XQ
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Zhang L
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

MeSH

ApoptosisCardiovascular DiseasesEnergy MetabolismGene Expression RegulationGenome, MitochondrialHumansInflammationMicroRNAsMitochondriaMitochondrial ProteinsOxidative Stress

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31766319

Citation

Song, Rui, et al. "Mitochondrial MiRNA in Cardiovascular Function and Disease." Cells, vol. 8, no. 12, 2019.
Song R, Hu XQ, Zhang L. Mitochondrial MiRNA in Cardiovascular Function and Disease. Cells. 2019;8(12).
Song, R., Hu, X. Q., & Zhang, L. (2019). Mitochondrial MiRNA in Cardiovascular Function and Disease. Cells, 8(12). https://doi.org/10.3390/cells8121475
Song R, Hu XQ, Zhang L. Mitochondrial MiRNA in Cardiovascular Function and Disease. Cells. 2019 11 21;8(12) PubMed PMID: 31766319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial MiRNA in Cardiovascular Function and Disease. AU - Song,Rui, AU - Hu,Xiang-Qun, AU - Zhang,Lubo, Y1 - 2019/11/21/ PY - 2019/10/21/received PY - 2019/11/13/revised PY - 2019/11/18/accepted PY - 2019/11/27/entrez PY - 2019/11/27/pubmed PY - 2020/8/18/medline KW - cardiovascular disease KW - miRNA KW - mitochondria KW - mitomiR JF - Cells JO - Cells VL - 8 IS - 12 N2 - MicroRNAs (miRNAs) are small noncoding RNAs functioning as crucial post-transcriptional regulators of gene expression involved in cardiovascular development and health. Recently, mitochondrial miRNAs (mitomiRs) have been shown to modulate the translational activity of the mitochondrial genome and regulating mitochondrial protein expression and function. Although mitochondria have been verified to be essential for the development and as a therapeutic target for cardiovascular diseases, we are just beginning to understand the roles of mitomiRs in the regulation of crucial biological processes, including energy metabolism, oxidative stress, inflammation, and apoptosis. In this review, we summarize recent findings regarding how mitomiRs impact on mitochondrial gene expression and mitochondrial function, which may help us better understand the contribution of mitomiRs to both the regulation of cardiovascular function under physiological conditions and the pathogenesis of cardiovascular diseases. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/31766319/Mitochondrial_MiRNA_in_Cardiovascular_Function_and_Disease_ DB - PRIME DP - Unbound Medicine ER -