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Low-Grade Ductal Carcinoma In Situ.

Abstract

OBJECTIVES

We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system.

METHODS

Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system.

RESULTS

Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235).

CONCLUSIONS

Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance.

Authors+Show Affiliations

University of Miami/Jackson Health System, Miami, FL.Mount Sinai Medical Center of Florida, Miami Beach.Mount Sinai Medical Center of Florida, Miami Beach.University of Miami/Jackson Health System, Miami, FL.University of Miami/Jackson Health System, Miami, FL.Department of Public Health Sciences, University of Miami, Miami, FL.Mount Sinai Medical Center of Florida, Miami Beach. Herbert Wertheim College of Medicine, Florida International University, Miami.Department of Public Health Sciences, University of Miami, Miami, FL. Miller School of Medicine, University of Miami, Miami, FL.Mount Sinai Medical Center of Florida, Miami Beach. Herbert Wertheim College of Medicine, Florida International University, Miami.Department of Public Health Sciences, University of Miami, Miami, FL. Miller School of Medicine, University of Miami, Miami, FL.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31769792

Citation

Alghamdi, Sarah A., et al. "Low-Grade Ductal Carcinoma in Situ." American Journal of Clinical Pathology, 2019.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, et al. Low-Grade Ductal Carcinoma In Situ. Am J Clin Pathol. 2019.
Alghamdi, S. A., Krishnamurthy, K., Garces Narvaez, S. A., Algashaamy, K. J., Aoun, J., Reis, I. M., ... Gomez-Fernandez, C. R. (2019). Low-Grade Ductal Carcinoma In Situ. American Journal of Clinical Pathology, doi:10.1093/ajcp/aqz179.
Alghamdi SA, et al. Low-Grade Ductal Carcinoma in Situ. Am J Clin Pathol. 2019 Nov 26; PubMed PMID: 31769792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-Grade Ductal Carcinoma In Situ. AU - Alghamdi,Sarah A, AU - Krishnamurthy,Kritika, AU - Garces Narvaez,Sofia A, AU - Algashaamy,Khaled J, AU - Aoun,Jessica, AU - Reis,Isildinha M, AU - Recine,Monica A, AU - Jorda,Merce, AU - Poppiti,Robert J, AU - Gomez-Fernandez,Carmen R, Y1 - 2019/11/26/ PY - 2019/11/27/entrez PY - 2019/11/27/pubmed PY - 2019/11/27/medline KW - Ductal carcinoma in situ KW - Grading system KW - Interobserver reproducibility KW - Low-grade DCIS JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. N2 - OBJECTIVES: We aimed to determine the interobserver reproducibility in diagnosing low-grade ductal carcinoma in situ (DCIS). We also aimed to compare the interobserver variability using a proposed two-tiered grading system as opposed to the current three-tiered system. METHODS: Three expert breast pathologists and one junior pathologist identified low-grade DCIS from a set of 300 DCIS slides. Months later, participants were asked to grade the 300 cases using the standard three-tiered system. RESULTS: Using the two-tiered system, interobserver agreement among breast pathologists was considered moderate (κ = 0.575). The agreement was similar (κ = 0.532) with the junior pathologist included. Using the three-tiered system, pathologists' agreement was poor (κ = 0.235). CONCLUSIONS: Pathologists' reproducibility on diagnosing low-grade DCIS showed moderate agreement. Experience does not seem to influence reproducibility. Our proposed two-tiered system of low vs nonlow grade, where the intermediate grade is grouped in the nonlow category has shown improved concordance. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/31769792/Low-Grade_Ductal_Carcinoma_In_Situ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/aqz179 DB - PRIME DP - Unbound Medicine ER -