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Nutritional vitamin D in CKD: Should we measure? Should we treat?
Clin Chim Acta. 2020 Feb; 501:186-197.CC

Abstract

Vitamin Ddeficiency is frequently present in patients affected by chronic kidney disease (CKD). Experimental studies demonstrated that Vitamin D may play a role in the pathophysiology of diseases beyond mineral bone disorders in CKD (CKD-MBD). Unfortunately, the lack of large and interventional studies focused on the so called "non-classic" effects of 25(OH) Vitamin D supplementation in CKD patients, doesn't permit to conclude definitely about the beneficial effects of this supplementation in clinical practice. In conclusion, treatment of nutritional vitamin D deficiency in CKD may play a central role in both bone homeostasis and cardiovascular outcomes, but there is not clear evidence to support one formulation of nutritional vitamin D over another in CKD.

Authors+Show Affiliations

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Bologna, Italy.Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Bologna, Italy.Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, Bologna, Italy.Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Italy.Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Italy. Electronic address: mario.cozzolino@unimi.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31770508

Citation

Capelli, Irene, et al. "Nutritional Vitamin D in CKD: Should We Measure? Should We Treat?" Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 501, 2020, pp. 186-197.
Capelli I, Cianciolo G, Gasperoni L, et al. Nutritional vitamin D in CKD: Should we measure? Should we treat? Clin Chim Acta. 2020;501:186-197.
Capelli, I., Cianciolo, G., Gasperoni, L., Galassi, A., Ciceri, P., & Cozzolino, M. (2020). Nutritional vitamin D in CKD: Should we measure? Should we treat? Clinica Chimica Acta; International Journal of Clinical Chemistry, 501, 186-197. https://doi.org/10.1016/j.cca.2019.11.010
Capelli I, et al. Nutritional Vitamin D in CKD: Should We Measure? Should We Treat. Clin Chim Acta. 2020;501:186-197. PubMed PMID: 31770508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional vitamin D in CKD: Should we measure? Should we treat? AU - Capelli,Irene, AU - Cianciolo,Giuseppe, AU - Gasperoni,Lorenzo, AU - Galassi,Andrea, AU - Ciceri,Paola, AU - Cozzolino,Mario, Y1 - 2019/11/23/ PY - 2019/09/06/received PY - 2019/11/04/revised PY - 2019/11/06/accepted PY - 2019/11/27/pubmed PY - 2020/7/30/medline PY - 2019/11/27/entrez KW - Chronic kidney disease KW - Secondary hyperparathyroidism KW - Vitamin D SP - 186 EP - 197 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 501 N2 - Vitamin Ddeficiency is frequently present in patients affected by chronic kidney disease (CKD). Experimental studies demonstrated that Vitamin D may play a role in the pathophysiology of diseases beyond mineral bone disorders in CKD (CKD-MBD). Unfortunately, the lack of large and interventional studies focused on the so called "non-classic" effects of 25(OH) Vitamin D supplementation in CKD patients, doesn't permit to conclude definitely about the beneficial effects of this supplementation in clinical practice. In conclusion, treatment of nutritional vitamin D deficiency in CKD may play a central role in both bone homeostasis and cardiovascular outcomes, but there is not clear evidence to support one formulation of nutritional vitamin D over another in CKD. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/31770508/Nutritional_vitamin_D_in_CKD:_Should_we_measure_Should_we_treat L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(19)32123-0 DB - PRIME DP - Unbound Medicine ER -