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The effects of caffeine on the postprandial fall of blood pressure in the elderly.
Age Ageing. 1988 Jul; 17(4):236-40.AA

Abstract

In a double-blind placebo-controlled study, we examined the effect of caffeine pretreatment on the haemodynamic and humoral changes after a standardized breakfast in 15 healthy elderly subjects (mean age 75.4 +/- 6.6 years). After placebo, the preprandial blood pressure did not change and the postprandial blood pressure declined by a maximum of 6.1%. After oral ingestion of 250 mg caffeine, 60 min before breakfast, the preprandial blood pressure increased by 12.5%. Although the decrease of the postprandial blood pressure was not altered, blood pressure remained above its basal value. The increase in plasma noradrenaline after the meal was similar in the placebo and the caffeine tests. Plasma adrenaline decreased after placebo (-19%) but did not change after caffeine. Thus, despite the unchanged decrease of the postprandial blood pressure, the preprandial pressor effect of caffeine prevented the decline of the postprandial blood pressure below its baseline value. The clinical relevance of this finding has still to be determined.

Authors+Show Affiliations

Department of Internal Medicine, St Raboud University Hospital, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3177083

Citation

Lenders, J W., et al. "The Effects of Caffeine On the Postprandial Fall of Blood Pressure in the Elderly." Age and Ageing, vol. 17, no. 4, 1988, pp. 236-40.
Lenders JW, Morre HL, Smits P, et al. The effects of caffeine on the postprandial fall of blood pressure in the elderly. Age Ageing. 1988;17(4):236-40.
Lenders, J. W., Morre, H. L., Smits, P., & Thien, T. (1988). The effects of caffeine on the postprandial fall of blood pressure in the elderly. Age and Ageing, 17(4), 236-40.
Lenders JW, et al. The Effects of Caffeine On the Postprandial Fall of Blood Pressure in the Elderly. Age Ageing. 1988;17(4):236-40. PubMed PMID: 3177083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of caffeine on the postprandial fall of blood pressure in the elderly. AU - Lenders,J W, AU - Morre,H L, AU - Smits,P, AU - Thien,T, PY - 1988/7/1/pubmed PY - 1988/7/1/medline PY - 1988/7/1/entrez SP - 236 EP - 40 JF - Age and ageing JO - Age Ageing VL - 17 IS - 4 N2 - In a double-blind placebo-controlled study, we examined the effect of caffeine pretreatment on the haemodynamic and humoral changes after a standardized breakfast in 15 healthy elderly subjects (mean age 75.4 +/- 6.6 years). After placebo, the preprandial blood pressure did not change and the postprandial blood pressure declined by a maximum of 6.1%. After oral ingestion of 250 mg caffeine, 60 min before breakfast, the preprandial blood pressure increased by 12.5%. Although the decrease of the postprandial blood pressure was not altered, blood pressure remained above its basal value. The increase in plasma noradrenaline after the meal was similar in the placebo and the caffeine tests. Plasma adrenaline decreased after placebo (-19%) but did not change after caffeine. Thus, despite the unchanged decrease of the postprandial blood pressure, the preprandial pressor effect of caffeine prevented the decline of the postprandial blood pressure below its baseline value. The clinical relevance of this finding has still to be determined. SN - 0002-0729 UR - https://www.unboundmedicine.com/medline/citation/3177083/The_effects_of_caffeine_on_the_postprandial_fall_of_blood_pressure_in_the_elderly_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/17.4.236 DB - PRIME DP - Unbound Medicine ER -