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Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats.
Bull Exp Biol Med. 2019 Dec; 168(2):250-253.BE

Abstract

We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shubina TA
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia. shubina.74@mail.ru.
Obergan TY
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Lyapina LA
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Grigorieva ME
Laboratory of Protective Blood Systems, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Myasoedov NF
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Andreeva LA
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

MeSH

Adrenocorticotropic HormoneAnimalsAnticoagulantsBlood CoagulationBlood PlateletsFibrinolysisHemostasisMaleOligopeptidesPlatelet Aggregation InhibitorsProlineRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31776957

Citation

Shubina, T A., et al. "Effect of a New Synthetic Peptide Preparation AСTH15-18PGP On the Hemostasis System in Rats." Bulletin of Experimental Biology and Medicine, vol. 168, no. 2, 2019, pp. 250-253.
Shubina TA, Obergan TY, Lyapina LA, et al. Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats. Bull Exp Biol Med. 2019;168(2):250-253.
Shubina, T. A., Obergan, T. Y., Lyapina, L. A., Grigorieva, M. E., Myasoedov, N. F., & Andreeva, L. A. (2019). Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats. Bulletin of Experimental Biology and Medicine, 168(2), 250-253. https://doi.org/10.1007/s10517-019-04685-9
Shubina TA, et al. Effect of a New Synthetic Peptide Preparation AСTH15-18PGP On the Hemostasis System in Rats. Bull Exp Biol Med. 2019;168(2):250-253. PubMed PMID: 31776957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a New Synthetic Peptide Preparation AСTH15-18PGP on the Hemostasis System in Rats. AU - Shubina,T A, AU - Obergan,T Yu, AU - Lyapina,L A, AU - Grigorieva,M E, AU - Myasoedov,N F, AU - Andreeva,L A, Y1 - 2019/11/27/ PY - 2019/03/04/received PY - 2019/11/30/pubmed PY - 2020/5/6/medline PY - 2019/11/29/entrez KW - AСTH15-18PGP KW - fibrinolysis KW - hemostasis KW - peptide KW - plasmin SP - 250 EP - 253 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 168 IS - 2 N2 - We studied the effect of chronic intranasal and peroral administration of a new peptide preparation AСTH15-18PGP in a dose of 100 mg/kg body weight on the state of vascular-platelet and plasma hemostasis in animals. It was found that this synthetic regulatory peptide administered intranasally can produce antiplatelet, anticoagulant, and antifibrin-stabilizing effects on the blood plasma in healthy rats. In both administration routes, the peptide induced activation of the anticoagulation system of the hemostasis by increasing enzymatic and non-enzymatic fibrinolysis; after intranasal administration, the fibrinolytic effects were more pronounced. SN - 1573-8221 UR - https://www.unboundmedicine.com/medline/citation/31776957/Effect_of_a_New_Synthetic_Peptide_Preparation_AСTH15_18PGP_on_the_Hemostasis_System_in_Rats_ DB - PRIME DP - Unbound Medicine ER -