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Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review.
Cureus 2019; 11(10):e5907C

Abstract

Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare (1 in 50,000), benign, autosomal dominant cutaneous disorder that causes a painful rash and blistering commonly occurring in the intertriginous folds. Despite having a good prognosis, there is no cure for HHD and the disease can be quite debilitating to the quality of life. The complexity of HHD can be compounded by superimposed eczema herpeticum (EH) or Kaposi's varicelliform eruption, which is caused by a viral infection occurring in preexistent cutaneous conditions. We present a unique clinical presentation of HHD with superimposed EH caused by herpes simplex virus type 2 (HSV-2) infection managed in a burn unit. It is highly advised that a recalcitrant HHD with superimposed EH caused by HSV-2 infection should be managed in burn centers that offer multimodalities for prompt, rigorous management. Early diagnosis and treatment are highly suggested for EH to avoid fatal complications.

Authors+Show Affiliations

General Surgery, St. John's Episcopal Hospital, Far Rockaway, USA.Surgery, Burn Center, The Johns Hopkins University School of Medicine, Baltimore, USA.Plastic Surgery, The Johns Hopkins University School of Medicine, Baltimore, USA.Surgery, Burn Center, The Johns Hopkins University School of Medicine, Baltimore, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31777694

Citation

Chin, An Guo Michael, et al. "Hailey-Hailey Disease With Superimposed Eczema Herpeticum Caused By Herpes Simplex Virus Type 2 Infection in a Burn Unit: a Case Report and Literature Review." Cureus, vol. 11, no. 10, 2019, pp. e5907.
Chin AGM, Asif M, Hultman C, et al. Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review. Cureus. 2019;11(10):e5907.
Chin, A. G. M., Asif, M., Hultman, C., & Caffrey, J. (2019). Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review. Cureus, 11(10), pp. e5907. doi:10.7759/cureus.5907.
Chin AGM, et al. Hailey-Hailey Disease With Superimposed Eczema Herpeticum Caused By Herpes Simplex Virus Type 2 Infection in a Burn Unit: a Case Report and Literature Review. Cureus. 2019 Oct 14;11(10):e5907. PubMed PMID: 31777694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review. AU - Chin,An Guo Michael, AU - Asif,Mohammed, AU - Hultman,Charles, AU - Caffrey,Julie, Y1 - 2019/10/14/ PY - 2019/11/29/entrez PY - 2019/11/30/pubmed PY - 2019/11/30/medline KW - burn KW - eczema herpeticum KW - familial benign pemphigus KW - hailey-hailey disease KW - herpes simplex virus type 2 KW - herpetic eczema KW - kaposi varicelliform KW - low dose naltrexone SP - e5907 EP - e5907 JF - Cureus JO - Cureus VL - 11 IS - 10 N2 - Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare (1 in 50,000), benign, autosomal dominant cutaneous disorder that causes a painful rash and blistering commonly occurring in the intertriginous folds. Despite having a good prognosis, there is no cure for HHD and the disease can be quite debilitating to the quality of life. The complexity of HHD can be compounded by superimposed eczema herpeticum (EH) or Kaposi's varicelliform eruption, which is caused by a viral infection occurring in preexistent cutaneous conditions. We present a unique clinical presentation of HHD with superimposed EH caused by herpes simplex virus type 2 (HSV-2) infection managed in a burn unit. It is highly advised that a recalcitrant HHD with superimposed EH caused by HSV-2 infection should be managed in burn centers that offer multimodalities for prompt, rigorous management. Early diagnosis and treatment are highly suggested for EH to avoid fatal complications. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31777694/Hailey-Hailey_Disease_with_Superimposed_Eczema_Herpeticum_Caused_by_Herpes_Simplex_Virus_Type_2_Infection_in_a_Burn_Unit:_A_Case_Report_and_Literature_Review L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31777694/ DB - PRIME DP - Unbound Medicine ER -