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Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology.
Am J Dermatopathol. 1988 Feb; 10(1):68-73.AJ

Abstract

Malignant acanthosis nigricans is usually associated with adenocarcinomas of the digestive tract. The lesions of acanthosis nigricans commonly run a parallel course to the associated malignancy, producing hyperpigmented, roughened plaques on the skin and, sometimes, verruca-like papules on the oral mucosa. The clinical differences between cutaneous and oral acanthosis nigricans are mirrored by the marked differences in the histopathology. Because oral acanthosis nigricans is uncommon, recognizing histologic features may be difficult. The oral lesions have a true acanthosis and epithelial papillary hyperplasia while the cutaneous forms show slight irregular acanthosis that alternates with areas of epidermal atrophy and dermal papillomatosis.

Authors+Show Affiliations

Hall JM
Dental Clinic, University of Saskatechewan, Saskatoon, Canada.
Moreland A
No affiliation info available
Cox GJ
No affiliation info available
Wade TR
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaCarcinoma in SituFemaleHumansLip DiseasesMiddle AgedNeoplasms, Multiple PrimarySigmoid NeoplasmsSkinStomach Neoplasms

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3177823

Citation

Hall, J M., et al. "Oral Acanthosis Nigricans: Report of a Case and Comparison of Oral and Cutaneous Pathology." The American Journal of Dermatopathology, vol. 10, no. 1, 1988, pp. 68-73.
Hall JM, Moreland A, Cox GJ, et al. Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology. Am J Dermatopathol. 1988;10(1):68-73.
Hall, J. M., Moreland, A., Cox, G. J., & Wade, T. R. (1988). Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology. The American Journal of Dermatopathology, 10(1), 68-73.
Hall JM, et al. Oral Acanthosis Nigricans: Report of a Case and Comparison of Oral and Cutaneous Pathology. Am J Dermatopathol. 1988;10(1):68-73. PubMed PMID: 3177823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral acanthosis nigricans: report of a case and comparison of oral and cutaneous pathology. AU - Hall,J M, AU - Moreland,A, AU - Cox,G J, AU - Wade,T R, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 68 EP - 73 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 10 IS - 1 N2 - Malignant acanthosis nigricans is usually associated with adenocarcinomas of the digestive tract. The lesions of acanthosis nigricans commonly run a parallel course to the associated malignancy, producing hyperpigmented, roughened plaques on the skin and, sometimes, verruca-like papules on the oral mucosa. The clinical differences between cutaneous and oral acanthosis nigricans are mirrored by the marked differences in the histopathology. Because oral acanthosis nigricans is uncommon, recognizing histologic features may be difficult. The oral lesions have a true acanthosis and epithelial papillary hyperplasia while the cutaneous forms show slight irregular acanthosis that alternates with areas of epidermal atrophy and dermal papillomatosis. SN - 0193-1091 UR - https://www.unboundmedicine.com/medline/citation/3177823/Oral_acanthosis_nigricans:_report_of_a_case_and_comparison_of_oral_and_cutaneous_pathology_ DB - PRIME DP - Unbound Medicine ER -