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The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial.
Complement Ther Med. 2019 Dec; 47:102183.CT

Abstract

OBJECTIVE

Sesame oil is an herbal product that has been used to treat the joints pain in several traditional medicines. In this study, we evaluated the efficacy of topical sesame oil versus diclofenac gel in patients with knee osteoarthritis (OA).

METHODS

One hundred and four patients were randomly enrolled in two arms of the trial. Patients were treated by topical sesame oil or diclofenac (three times a day) for 4 weeks. Outcome measures were knee pain via visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, knee joint's flexion angle, 8-meter walk test and number of used analgesics. Patients were evaluated at baseline, 2 and then 4 weeks after the intervention.

RESULTS

At the follow-up visits, sesame oil was not inferior to diclofenac regarding scores of WOMAC pain, 8-meter walk test, and knee flexion angle. Although, its non-inferiority was not proved regarding scores of VAS, WOMAC stiffness, and WOMAC total at the 4th week. Moreover, sesame oil was not inferior to diclofenac regarding consumed analgesics.

CONCLUSION

It seems that the topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee OA pain and improvement of some indicators of its function.

Authors+Show Affiliations

Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran; Orthopedic Department, Shiraz University of Medical Sciences, Shiraz, Iran.Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Research Center for Psychiatry and Behavior Science, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran; Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran; Department of Persian Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran. Electronic address: hashempur@gmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31780006

Citation

Askari, Alireza, et al. "The Efficacy of Topical Sesame Oil in Patients With Knee Osteoarthritis: a Randomized Double-blinded Active-controlled Non-inferiority Clinical Trial." Complementary Therapies in Medicine, vol. 47, 2019, p. 102183.
Askari A, Ravansalar SA, Naghizadeh MM, et al. The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial. Complement Ther Med. 2019;47:102183.
Askari, A., Ravansalar, S. A., Naghizadeh, M. M., Mosavat, S. H., Khodadoost, M., Jazani, A. M., & Hashempur, M. H. (2019). The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial. Complementary Therapies in Medicine, 47, 102183. https://doi.org/10.1016/j.ctim.2019.08.017
Askari A, et al. The Efficacy of Topical Sesame Oil in Patients With Knee Osteoarthritis: a Randomized Double-blinded Active-controlled Non-inferiority Clinical Trial. Complement Ther Med. 2019;47:102183. PubMed PMID: 31780006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of topical sesame oil in patients with knee osteoarthritis: A randomized double-blinded active-controlled non-inferiority clinical trial. AU - Askari,Alireza, AU - Ravansalar,Seyed Ali, AU - Naghizadeh,Mohammad Mehdi, AU - Mosavat,Seyed Hamdollah, AU - Khodadoost,Mahmood, AU - Jazani,Arezoo Moini, AU - Hashempur,Mohammad Hashem, Y1 - 2019/08/22/ PY - 2019/05/19/received PY - 2019/07/24/revised PY - 2019/08/21/accepted PY - 2019/11/30/entrez PY - 2019/11/30/pubmed PY - 2020/4/11/medline KW - Complementary medicine KW - Diclofenac KW - Knee osteoarthritis KW - Sesame KW - Sesamum indicum KW - Traditional Persian medicine SP - 102183 EP - 102183 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 47 N2 - OBJECTIVE: Sesame oil is an herbal product that has been used to treat the joints pain in several traditional medicines. In this study, we evaluated the efficacy of topical sesame oil versus diclofenac gel in patients with knee osteoarthritis (OA). METHODS: One hundred and four patients were randomly enrolled in two arms of the trial. Patients were treated by topical sesame oil or diclofenac (three times a day) for 4 weeks. Outcome measures were knee pain via visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire, knee joint's flexion angle, 8-meter walk test and number of used analgesics. Patients were evaluated at baseline, 2 and then 4 weeks after the intervention. RESULTS: At the follow-up visits, sesame oil was not inferior to diclofenac regarding scores of WOMAC pain, 8-meter walk test, and knee flexion angle. Although, its non-inferiority was not proved regarding scores of VAS, WOMAC stiffness, and WOMAC total at the 4th week. Moreover, sesame oil was not inferior to diclofenac regarding consumed analgesics. CONCLUSION: It seems that the topical sesame oil was non-inferior to diclofenac gel on the reduction of the knee OA pain and improvement of some indicators of its function. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/31780006/The_efficacy_of_topical_sesame_oil_in_patients_with_knee_osteoarthritis:_A_randomized_double_blinded_active_controlled_non_inferiority_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(19)30716-2 DB - PRIME DP - Unbound Medicine ER -