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Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.
Complement Ther Med. 2019 Dec; 47:102226.CT

Abstract

OBJECTIVES

We carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of L-arginine on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6) and TNFα.

METHODS

A systematic search was carried out in PubMed, Embase, Scopus, Cochrane library databases and ISI web of sciences to retrieve the RCTs which examined the effect of L-arginine supplementation on inflammatory biomarkers up to October 2019, with no language and time restriction. Meta-analysis was performed using a random effects model, and I2 index was used to evaluate the heterogeneity.

RESULTS

Search yielded 2452 publications. Eleven RCTs were eligible. Results indicated that L-arginine supplementation had no significant effect on inflammatory biomarkers including CRP, IL-6 and TNFα. However, when subgroup analysis was performed, we found that L-arginine supplementation increased CRP levels in subjects with ages >60 years old, participants with baseline circulating CRP levels >3 mg/dl, patients with cancer and when used in enteral formula.

CONCLUSION

Results of the present meta-analysis indicated that L-arginine supplementation increased the circulating concentrations of CRP in subjects with ages >60 years old, subjects with higher levels of CRP, patients with cancer and when used in enteral formula. Therefore, L-arginine should be used with caution in these subjects. However, further well designed, large-scale studies are needed.

Authors+Show Affiliations

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Razi Herbal Medicines Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. Electronic address: abbasnezhad.amir@lums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31780028

Citation

Nazarian, Behzad, et al. "Effect of L-arginine Supplementation On C-reactive Protein and Other Inflammatory Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Complementary Therapies in Medicine, vol. 47, 2019, p. 102226.
Nazarian B, Fazeli Moghadam E, Asbaghi O, et al. Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med. 2019;47:102226.
Nazarian, B., Fazeli Moghadam, E., Asbaghi, O., Zeinali Khosroshahi, M., Choghakhori, R., & Abbasnezhad, A. (2019). Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 47, 102226. https://doi.org/10.1016/j.ctim.2019.102226
Nazarian B, et al. Effect of L-arginine Supplementation On C-reactive Protein and Other Inflammatory Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Complement Ther Med. 2019;47:102226. PubMed PMID: 31780028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. AU - Nazarian,Behzad, AU - Fazeli Moghadam,Ezatollah, AU - Asbaghi,Omid, AU - Zeinali Khosroshahi,Mohammad, AU - Choghakhori,Razieh, AU - Abbasnezhad,Amir, Y1 - 2019/10/31/ PY - 2019/09/23/received PY - 2019/10/22/revised PY - 2019/10/23/accepted PY - 2019/11/30/entrez PY - 2019/11/30/pubmed PY - 2020/4/11/medline KW - C-reactive protein KW - Inflammatory biomarkers KW - Meta-analysis KW - TNFα KW - interleukin-6 KW - l-arginine SP - 102226 EP - 102226 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 47 N2 - OBJECTIVES: We carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of L-arginine on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6) and TNFα. METHODS: A systematic search was carried out in PubMed, Embase, Scopus, Cochrane library databases and ISI web of sciences to retrieve the RCTs which examined the effect of L-arginine supplementation on inflammatory biomarkers up to October 2019, with no language and time restriction. Meta-analysis was performed using a random effects model, and I2 index was used to evaluate the heterogeneity. RESULTS: Search yielded 2452 publications. Eleven RCTs were eligible. Results indicated that L-arginine supplementation had no significant effect on inflammatory biomarkers including CRP, IL-6 and TNFα. However, when subgroup analysis was performed, we found that L-arginine supplementation increased CRP levels in subjects with ages >60 years old, participants with baseline circulating CRP levels >3 mg/dl, patients with cancer and when used in enteral formula. CONCLUSION: Results of the present meta-analysis indicated that L-arginine supplementation increased the circulating concentrations of CRP in subjects with ages >60 years old, subjects with higher levels of CRP, patients with cancer and when used in enteral formula. Therefore, L-arginine should be used with caution in these subjects. However, further well designed, large-scale studies are needed. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/31780028/Effect_of_l_arginine_supplementation_on_C_reactive_protein_and_other_inflammatory_biomarkers:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -