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Clinical evidence of Chinese medicine therapies for depression in women during perimenopause and menopause.
Complement Ther Med 2019; 47:102071CT

Abstract

BACKGROUND

Depression is common in women during perimenopause and menopause. Complementary therapies such as acupuncture and Chinese herbal medicine (CHM) are often utilized by these women. However, the efficacy and safety of these treatments have not been systematically evaluated.

METHODS

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). Nine English and Chinese databases were searched and search terms included perimenopause, menopause, depression, Chinese herbal medicine, acupuncture, RCTs, and their synonyms. Methodological quality was assessed using the Cochrane Risk of Bias Tool.

RESULTS

A total of 18 RCTs were identified (6 CHM, 11 acupuncture related therapies, 1 combination of CHM and acupuncture). For Hamilton Rating Scale of Depression (HRSD) and Kuppermans Index of Menopause, tuina-massage, combined therapy of CHM plus acupuncture showed significant benefits at end of treatment compared to antidepressants. Either CHM and acupuncture reduced HRSD scores, indicating less severe depression, showing comparable effects to antidepressants.

CONCLUSION

CHM and acupuncture treatment in perimenopause and menopausal women resulted in reduced severity of depression. Results should be interpreted with caution given the small number of studies included in this review and further RCTs are warranted to validate findings from this review.

Authors+Show Affiliations

The China-AustraliaInternational Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China.The China-AustraliaInternational Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.The China-AustraliaInternational Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China.Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China.The China-AustraliaInternational Research Centre for Chinese Medicine, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia; Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China.Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese Medicine, Yuexiu District, Guangzhou, PR China. Electronic address: luchuanjian888@vip.sina.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31780032

Citation

Di, Yuan Ming, et al. "Clinical Evidence of Chinese Medicine Therapies for Depression in Women During Perimenopause and Menopause." Complementary Therapies in Medicine, vol. 47, 2019, p. 102071.
Di YM, Yang L, Shergis JL, et al. Clinical evidence of Chinese medicine therapies for depression in women during perimenopause and menopause. Complement Ther Med. 2019;47:102071.
Di, Y. M., Yang, L., Shergis, J. L., Zhang, A. L., Li, Y., Guo, X., ... Lu, C. (2019). Clinical evidence of Chinese medicine therapies for depression in women during perimenopause and menopause. Complementary Therapies in Medicine, 47, p. 102071. doi:10.1016/j.ctim.2019.03.019.
Di YM, et al. Clinical Evidence of Chinese Medicine Therapies for Depression in Women During Perimenopause and Menopause. Complement Ther Med. 2019;47:102071. PubMed PMID: 31780032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evidence of Chinese medicine therapies for depression in women during perimenopause and menopause. AU - Di,Yuan Ming, AU - Yang,Lingling, AU - Shergis,Johannah L, AU - Zhang,Anthony L, AU - Li,Yan, AU - Guo,Xinfeng, AU - Xue,Charlie C, AU - Lu,Chuanjian, Y1 - 2019/03/28/ PY - 2018/12/04/received PY - 2019/03/19/revised PY - 2019/03/26/accepted PY - 2019/11/30/entrez PY - 2019/11/30/pubmed PY - 2019/11/30/medline KW - Acupuncture KW - Chinese herbal medicine KW - Depression KW - Menopause KW - Perimenopause KW - Review SP - 102071 EP - 102071 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 47 N2 - BACKGROUND: Depression is common in women during perimenopause and menopause. Complementary therapies such as acupuncture and Chinese herbal medicine (CHM) are often utilized by these women. However, the efficacy and safety of these treatments have not been systematically evaluated. METHODS: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). Nine English and Chinese databases were searched and search terms included perimenopause, menopause, depression, Chinese herbal medicine, acupuncture, RCTs, and their synonyms. Methodological quality was assessed using the Cochrane Risk of Bias Tool. RESULTS: A total of 18 RCTs were identified (6 CHM, 11 acupuncture related therapies, 1 combination of CHM and acupuncture). For Hamilton Rating Scale of Depression (HRSD) and Kuppermans Index of Menopause, tuina-massage, combined therapy of CHM plus acupuncture showed significant benefits at end of treatment compared to antidepressants. Either CHM and acupuncture reduced HRSD scores, indicating less severe depression, showing comparable effects to antidepressants. CONCLUSION: CHM and acupuncture treatment in perimenopause and menopausal women resulted in reduced severity of depression. Results should be interpreted with caution given the small number of studies included in this review and further RCTs are warranted to validate findings from this review. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/31780032/Clinical_evidence_of_Chinese_medicine_therapies_for_depression_in_women_during_perimenopause_and_menopause L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(18)31198-1 DB - PRIME DP - Unbound Medicine ER -