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Effects of photobiomodualtion therapy on breast cancer-related lymphoedema: A systematic review and meta-analysis of randomised controlled trials.
Complement Ther Med 2019; 47:102200CT

Abstract

OBJECTIVE

Lymphoedema characterised by the persistent accumulation of the interstitial fluid in peripheral tissues post breast cancer treatments. Photobiomodualtion therapy (PBMT) is widely used as supportive care in patients with breast cancer or breast cancer-related lymphoedema (BCRL). This systematic review and meta-analysis analysed the effectiveness and safety of PBMT for the treatment of BCRL.

METHOD

PubMed, EMBASE, PEDro, SCOPUS, CINAHL, and Cochrane Central Register of Controlled Trials were searched for RCTs on PBMT published before July 2019. Randomised controlled trials (RCTs) that evaluated the efficacy of PBMT on BCRL were included. The primary outcome was the arm circumference or volume, and secondary outcomes were grip strength and pain scores. This study is registered with PROSPERO (number CRD 42018102107).

RESULTS

We reviewed nine RCTs that included 316 patients and six studies for mata-analysis. We found no significant difference in the reduction of the arm circumference or arm volume after treatment, one month, and three month follow-up between the PBMT and control groups. Studies revealed no significant differences in the reduction in grip strength and pain scores at 0, 1, 2, and 3 month between the PBMT and control groups.

CONCLUSIONS

Although PBMT demonstrated a slight improvement in reducing arm circumference and arm volume, the results of our meta-analysis did not show significant benefits in relieving of lymphoedema. Further trials are needed to recruit more participants, and to evaluate the long-term efficacy and safety of PBMT in management of breast cancer-related lymphoedema.

Authors+Show Affiliations

School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of General Medicine, Chang Chung Memorial Hospital, Taoyuan, Taiwan.School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan; Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan; School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan. Electronic address: tsaiwei@tmu.edu.tw.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31780036

Citation

Chen, Hsuan-Yu, et al. "Effects of Photobiomodualtion Therapy On Breast Cancer-related Lymphoedema: a Systematic Review and Meta-analysis of Randomised Controlled Trials." Complementary Therapies in Medicine, vol. 47, 2019, p. 102200.
Chen HY, Tsai HH, Tam KW, et al. Effects of photobiomodualtion therapy on breast cancer-related lymphoedema: A systematic review and meta-analysis of randomised controlled trials. Complement Ther Med. 2019;47:102200.
Chen, H. Y., Tsai, H. H., Tam, K. W., & Huang, T. W. (2019). Effects of photobiomodualtion therapy on breast cancer-related lymphoedema: A systematic review and meta-analysis of randomised controlled trials. Complementary Therapies in Medicine, 47, p. 102200. doi:10.1016/j.ctim.2019.102200.
Chen HY, et al. Effects of Photobiomodualtion Therapy On Breast Cancer-related Lymphoedema: a Systematic Review and Meta-analysis of Randomised Controlled Trials. Complement Ther Med. 2019;47:102200. PubMed PMID: 31780036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of photobiomodualtion therapy on breast cancer-related lymphoedema: A systematic review and meta-analysis of randomised controlled trials. AU - Chen,Hsuan-Yu, AU - Tsai,Hui-Hsuan, AU - Tam,Ka-Wai, AU - Huang,Tsai-Wei, Y1 - 2019/09/24/ PY - 2019/07/31/received PY - 2019/09/20/revised PY - 2019/09/23/accepted PY - 2019/11/30/entrez PY - 2019/11/30/pubmed PY - 2019/11/30/medline KW - Breast cancer KW - Low-level laser therapy KW - Lymphoedema KW - Meta-analysis KW - Photobiomodualtion therapy SP - 102200 EP - 102200 JF - Complementary therapies in medicine JO - Complement Ther Med VL - 47 N2 - OBJECTIVE: Lymphoedema characterised by the persistent accumulation of the interstitial fluid in peripheral tissues post breast cancer treatments. Photobiomodualtion therapy (PBMT) is widely used as supportive care in patients with breast cancer or breast cancer-related lymphoedema (BCRL). This systematic review and meta-analysis analysed the effectiveness and safety of PBMT for the treatment of BCRL. METHOD: PubMed, EMBASE, PEDro, SCOPUS, CINAHL, and Cochrane Central Register of Controlled Trials were searched for RCTs on PBMT published before July 2019. Randomised controlled trials (RCTs) that evaluated the efficacy of PBMT on BCRL were included. The primary outcome was the arm circumference or volume, and secondary outcomes were grip strength and pain scores. This study is registered with PROSPERO (number CRD 42018102107). RESULTS: We reviewed nine RCTs that included 316 patients and six studies for mata-analysis. We found no significant difference in the reduction of the arm circumference or arm volume after treatment, one month, and three month follow-up between the PBMT and control groups. Studies revealed no significant differences in the reduction in grip strength and pain scores at 0, 1, 2, and 3 month between the PBMT and control groups. CONCLUSIONS: Although PBMT demonstrated a slight improvement in reducing arm circumference and arm volume, the results of our meta-analysis did not show significant benefits in relieving of lymphoedema. Further trials are needed to recruit more participants, and to evaluate the long-term efficacy and safety of PBMT in management of breast cancer-related lymphoedema. SN - 1873-6963 UR - https://www.unboundmedicine.com/medline/citation/31780036/Effects_of_photobiomodualtion_therapy_on_breast_cancer-related_lymphoedema:_A_systematic_review_and_meta-analysis_of_randomised_controlled_trials L2 - https://linkinghub.elsevier.com/retrieve/pii/S0965-2299(19)31123-9 DB - PRIME DP - Unbound Medicine ER -