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Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).
Gut. 2020 03; 69(3):411-444.Gut

Abstract

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk.

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Authors+Show Affiliations

Monahan KJ
Family Cancer Clinic, St Mark's Hospital, London, UK k.monahan@imperial.ac.uk. Faculty of Medicine, Imperial College, London, UK.
Bradshaw N
Clinical Genetics, West of Scotland Genetics Services, Glasgow, Glasgow, UK.
Dolwani S
Gastroenterology, Cardiff and Vale NHS Trust, Cardiff, UK.
Desouza B
Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Dunlop MG
CCGG, University of Edinburgh, Edinburgh, UK.
East JE
Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK. Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Ilyas M
Faculty of Medicine & Health Sciences, Nottingham University, Nottingham, UK.
Kaur A
Head of Policy and Campaigns, Bowel Cancer UK, London, UK.
Lalloo F
Genetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
Latchford A
Polyposis Registry, St Mark's Hospital, London, UK.
Rutter MD
Gastroenterology, University Hospital of North Tees, Stockton-on-Tees, UK. Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Tomlinson I
Nuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, Birmingham, UK. Cancer Research Centre, University of Edinburgh, Edinburgh, UK.
Thomas HJW
Family Cancer Clinic, St Mark's Hospital, London, UK. Faculty of Medicine, Imperial College, London, UK.
Hill J
Genetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
Hereditary CRC guidelines eDelphi consensus group
No affiliation info available

MeSH

Adenomatous Polyposis ColiColonoscopyColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA GlycosylasesFamily HealthHumansIntestinal PolyposisIrelandLife StyleNeoplastic Syndromes, HereditaryPeutz-Jeghers SyndromePopulation SurveillanceReferral and ConsultationRisk FactorsUnited Kingdom

Pub Type(s)

Journal Article
Practice Guideline
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31780574

Citation

Monahan, Kevin J., et al. "Guidelines for the Management of Hereditary Colorectal Cancer From the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)." Gut, vol. 69, no. 3, 2020, pp. 411-444.
Monahan KJ, Bradshaw N, Dolwani S, et al. Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut. 2020;69(3):411-444.
Monahan, K. J., Bradshaw, N., Dolwani, S., Desouza, B., Dunlop, M. G., East, J. E., Ilyas, M., Kaur, A., Lalloo, F., Latchford, A., Rutter, M. D., Tomlinson, I., Thomas, H. J. W., & Hill, J. (2020). Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut, 69(3), 411-444. https://doi.org/10.1136/gutjnl-2019-319915
Monahan KJ, et al. Guidelines for the Management of Hereditary Colorectal Cancer From the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut. 2020;69(3):411-444. PubMed PMID: 31780574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). AU - Monahan,Kevin J, AU - Bradshaw,Nicola, AU - Dolwani,Sunil, AU - Desouza,Bianca, AU - Dunlop,Malcolm G, AU - East,James E, AU - Ilyas,Mohammad, AU - Kaur,Asha, AU - Lalloo,Fiona, AU - Latchford,Andrew, AU - Rutter,Matthew D, AU - Tomlinson,Ian, AU - Thomas,Huw J W, AU - Hill,James, AU - ,, Y1 - 2019/11/28/ PY - 2019/09/20/received PY - 2019/10/25/revised PY - 2019/11/05/accepted PY - 2019/11/30/pubmed PY - 2020/4/15/medline PY - 2019/11/30/entrez KW - colorectal cancer KW - colorectal surgery KW - genetic testing KW - inherited cancers KW - surveillance SP - 411 EP - 444 JF - Gut JO - Gut VL - 69 IS - 3 N2 - Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/31780574/Guidelines_for_the_management_of_hereditary_colorectal_cancer_from_the_British_Society_of_Gastroenterology__BSG_/Association_of_Coloproctology_of_Great_Britain_and_Ireland__ACPGBI_/United_Kingdom_Cancer_Genetics_Group__UKCGG__ L2 - http://gut.bmj.com/lookup/pmidlookup?view=long&pmid=31780574 DB - PRIME DP - Unbound Medicine ER -