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Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility.

Abstract

The variation of stimulus intensity of manual acupuncture (MA) may produce diverse acupuncture effects. However, the intensity-effect relationship and the underlying mechanism of MA are still elusive. In this study, the effects of MA regulation of gastric motility were investigated after lifting-thrusting MA treatment with four different frequencies (1 Hz, 2 Hz, 3 Hz, and 4 Hz) at ST36. The experiments were conducted on rats with gastric hypomotility caused by atropine. The results showed that the gastric motility amplitude decreased after atropine injection, while the treatment of four types of MA affected the gastric motility amplitude in varying degrees. Specifically, 2 Hz MA exhibited the most effective results, while 4 Hz MA had the least effect; the effects of 1 Hz MA and 3 Hz MA were between the effects induced with 2 Hz and 4 Hz. Furthermore, the response of gastric vagal afferent nerve discharge and gastric motility was examined after MA treatment with frequencies of 2 Hz and 4 Hz, respectively, on ST36 in order to elucidate the mechanism of MA regulation of gastric motility. The results showed that 2 Hz MA was able to increase the amplitude of gastric motility and discharge frequency of gastric vagal afferent nerves, while 4 Hz MA exhibited seldom effects. These findings suggest that gentle MA (2 Hz) has more stimulating effects than strong stimulation with MA (4 Hz) on gastric hypomotility. In addition, gastric motility regulated by MA was associated with vagal afferent nerve activation.

Authors+Show Affiliations

Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China.Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China. Acupuncture and Massage Department, Qingyang Hospital of Traditional Chinese Medicine, No. 10, Guxiang West Road, Qingyang City, Gansu 745000, China.Acupuncture Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 88, Changling Road, Xiqing District, Tianjin 300391, China.Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China.Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China.Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China.Acupuncture Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No. 88, Changling Road, Xiqing District, Tianjin 300391, China.Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China. Chinese Medical College, Tianjin University of Traditional Chinese Medicine, No. 10, Poyang Lake Road, Tuanbo New Town, Jinghai District, Tianjin 301617, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31781283

Citation

Liu, Yangyang, et al. "Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats With Gastric Hypomotility." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2019, 2019, p. 9043151.
Liu Y, Bai Y, Pan Y, et al. Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility. Evid Based Complement Alternat Med. 2019;2019:9043151.
Liu, Y., Bai, Y., Pan, Y., Xu, Z., Fang, Y., Wang, S., ... Guo, Y. (2019). Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility. Evidence-based Complementary and Alternative Medicine : ECAM, 2019, p. 9043151. doi:10.1155/2019/9043151.
Liu Y, et al. Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats With Gastric Hypomotility. Evid Based Complement Alternat Med. 2019;2019:9043151. PubMed PMID: 31781283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gentle Manual Acupuncture Could Better Regulate Gastric Motility and Vagal Afferent Nerve Discharge of Rats with Gastric Hypomotility. AU - Liu,Yangyang, AU - Bai,Yang, AU - Pan,Yue, AU - Xu,Zhifang, AU - Fang,Yuxin, AU - Wang,Shenjun, AU - Du,Yuanhao, AU - Guo,Yi, Y1 - 2019/10/24/ PY - 2019/06/05/received PY - 2019/09/15/revised PY - 2019/09/30/accepted PY - 2019/11/30/entrez PY - 2019/11/30/pubmed PY - 2019/11/30/medline SP - 9043151 EP - 9043151 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2019 N2 - The variation of stimulus intensity of manual acupuncture (MA) may produce diverse acupuncture effects. However, the intensity-effect relationship and the underlying mechanism of MA are still elusive. In this study, the effects of MA regulation of gastric motility were investigated after lifting-thrusting MA treatment with four different frequencies (1 Hz, 2 Hz, 3 Hz, and 4 Hz) at ST36. The experiments were conducted on rats with gastric hypomotility caused by atropine. The results showed that the gastric motility amplitude decreased after atropine injection, while the treatment of four types of MA affected the gastric motility amplitude in varying degrees. Specifically, 2 Hz MA exhibited the most effective results, while 4 Hz MA had the least effect; the effects of 1 Hz MA and 3 Hz MA were between the effects induced with 2 Hz and 4 Hz. Furthermore, the response of gastric vagal afferent nerve discharge and gastric motility was examined after MA treatment with frequencies of 2 Hz and 4 Hz, respectively, on ST36 in order to elucidate the mechanism of MA regulation of gastric motility. The results showed that 2 Hz MA was able to increase the amplitude of gastric motility and discharge frequency of gastric vagal afferent nerves, while 4 Hz MA exhibited seldom effects. These findings suggest that gentle MA (2 Hz) has more stimulating effects than strong stimulation with MA (4 Hz) on gastric hypomotility. In addition, gastric motility regulated by MA was associated with vagal afferent nerve activation. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/31781283/Gentle_Manual_Acupuncture_Could_Better_Regulate_Gastric_Motility_and_Vagal_Afferent_Nerve_Discharge_of_Rats_with_Gastric_Hypomotility L2 - https://dx.doi.org/10.1155/2019/9043151 DB - PRIME DP - Unbound Medicine ER -