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Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus.
Appl Microbiol Biotechnol. 2020 Jan; 104(2):475-488.AM

Abstract

Among the so-called non-conventional yeasts, Kluyveromyces marxianus has extremely potent traits that are suitable for industrial applications. Indeed, it has been used for the production of various enzymes, chemicals, and macromolecules in addition to utilization of cell biomass as nutritional materials, feed and probiotics. The yeast is expected to be an efficient ethanol producer with advantages over Saccharomyces cerevisiae in terms of high growth rate, thermotolerance and a wide sugar assimilation spectrum. Results of comprehensive analyses of its genome and transcriptome may accelerate studies for applications of the yeast and may further increase its potential by combination with recent biotechnological tools including the CRISPR/Cas9 system. We thus review published studies by merging with information obtained from comprehensive data including genomic and transcriptomic data, which would be useful for future applications of K. marxianus.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Nurcholis M
Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan. Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Malang, 65145, Indonesia.
Lertwattanasakul N
Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand.
Rodrussamee N
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand. Center of Excellence in Bioresources for Agriculture, Industry and Medicine, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Kosaka T
Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan. Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan. Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Murata M
Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan. Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan.
Yamada M
Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan. m-yamada@yamaguchi-u.ac.jp. Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan. m-yamada@yamaguchi-u.ac.jp. Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan. m-yamada@yamaguchi-u.ac.jp. Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, 753-8515, Japan. m-yamada@yamaguchi-u.ac.jp.

MeSH

BiotechnologyGene Expression ProfilingGenomicsIndustrial MicrobiologyKluyveromycesMetabolic Engineering

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31781815

Citation

Nurcholis, Mochamad, et al. "Integration of Comprehensive Data and Biotechnological Tools for Industrial Applications of Kluyveromyces Marxianus." Applied Microbiology and Biotechnology, vol. 104, no. 2, 2020, pp. 475-488.
Nurcholis M, Lertwattanasakul N, Rodrussamee N, et al. Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. Appl Microbiol Biotechnol. 2020;104(2):475-488.
Nurcholis, M., Lertwattanasakul, N., Rodrussamee, N., Kosaka, T., Murata, M., & Yamada, M. (2020). Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. Applied Microbiology and Biotechnology, 104(2), 475-488. https://doi.org/10.1007/s00253-019-10224-3
Nurcholis M, et al. Integration of Comprehensive Data and Biotechnological Tools for Industrial Applications of Kluyveromyces Marxianus. Appl Microbiol Biotechnol. 2020;104(2):475-488. PubMed PMID: 31781815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. AU - Nurcholis,Mochamad, AU - Lertwattanasakul,Noppon, AU - Rodrussamee,Nadchanok, AU - Kosaka,Tomoyuki, AU - Murata,Masayuki, AU - Yamada,Mamoru, Y1 - 2019/11/28/ PY - 2019/09/07/received PY - 2019/10/27/accepted PY - 2019/10/21/revised PY - 2019/11/30/pubmed PY - 2020/6/4/medline PY - 2019/11/30/entrez KW - Biotechnological tools KW - Glucose sensing KW - Kluyveromyces marxianus KW - Mig1 regulation KW - Transcriptome KW - Useful materials production SP - 475 EP - 488 JF - Applied microbiology and biotechnology JO - Appl Microbiol Biotechnol VL - 104 IS - 2 N2 - Among the so-called non-conventional yeasts, Kluyveromyces marxianus has extremely potent traits that are suitable for industrial applications. Indeed, it has been used for the production of various enzymes, chemicals, and macromolecules in addition to utilization of cell biomass as nutritional materials, feed and probiotics. The yeast is expected to be an efficient ethanol producer with advantages over Saccharomyces cerevisiae in terms of high growth rate, thermotolerance and a wide sugar assimilation spectrum. Results of comprehensive analyses of its genome and transcriptome may accelerate studies for applications of the yeast and may further increase its potential by combination with recent biotechnological tools including the CRISPR/Cas9 system. We thus review published studies by merging with information obtained from comprehensive data including genomic and transcriptomic data, which would be useful for future applications of K. marxianus. SN - 1432-0614 UR - https://www.unboundmedicine.com/medline/citation/31781815/Integration_of_comprehensive_data_and_biotechnological_tools_for_industrial_applications_of_Kluyveromyces_marxianus_ DB - PRIME DP - Unbound Medicine ER -