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Red cell distribution width, mean corpuscular volume, and transferrin saturation in the diagnosis of iron deficiency.
Arch Intern Med. 1988 Oct; 148(10):2128-30.AI

Abstract

The usefulness of the red cell distribution width, mean corpuscular volume, and the transferrin saturation in diagnosing iron deficiency anemia were evaluated in a retrospective study of 247 anemic hospitalized patients, many of whom had chronic liver disease. A red cell distribution width greater than 15% had a sensitivity of 71% and a specificity of 54% for iron deficiency as diagnosed by a low serum ferritin or bone marrow examination. A mean corpuscular volume less than 80 femtoliters had a sensitivity of 53% and a specificity of 84%. Transferrin saturation less than 16% had a sensitivity of 61% and a specificity of 86%. Because the sensitivities and specificities of these tests are less than reported in studies of healthier populations, they cannot be relied on for screening for iron deficiency in sick hospitalized patients.

Authors+Show Affiliations

Thompson WG
Department of Medicine, New York University School of Medicine, New York.
Meola T
No affiliation info available
Lipkin M
No affiliation info available
Freedman ML
No affiliation info available

MeSH

Anemia, HypochromicBone Marrow ExaminationErythrocyte IndicesErythrocytesFemaleFerritinsHumansIronMalePredictive Value of TestsRetrospective StudiesTransferrin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3178371

Citation

Thompson, W G., et al. "Red Cell Distribution Width, Mean Corpuscular Volume, and Transferrin Saturation in the Diagnosis of Iron Deficiency." Archives of Internal Medicine, vol. 148, no. 10, 1988, pp. 2128-30.
Thompson WG, Meola T, Lipkin M, et al. Red cell distribution width, mean corpuscular volume, and transferrin saturation in the diagnosis of iron deficiency. Arch Intern Med. 1988;148(10):2128-30.
Thompson, W. G., Meola, T., Lipkin, M., & Freedman, M. L. (1988). Red cell distribution width, mean corpuscular volume, and transferrin saturation in the diagnosis of iron deficiency. Archives of Internal Medicine, 148(10), 2128-30.
Thompson WG, et al. Red Cell Distribution Width, Mean Corpuscular Volume, and Transferrin Saturation in the Diagnosis of Iron Deficiency. Arch Intern Med. 1988;148(10):2128-30. PubMed PMID: 3178371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red cell distribution width, mean corpuscular volume, and transferrin saturation in the diagnosis of iron deficiency. AU - Thompson,W G, AU - Meola,T, AU - Lipkin,M,Jr AU - Freedman,M L, PY - 1988/10/1/pubmed PY - 2001/3/28/medline PY - 1988/10/1/entrez SP - 2128 EP - 30 JF - Archives of internal medicine JO - Arch Intern Med VL - 148 IS - 10 N2 - The usefulness of the red cell distribution width, mean corpuscular volume, and the transferrin saturation in diagnosing iron deficiency anemia were evaluated in a retrospective study of 247 anemic hospitalized patients, many of whom had chronic liver disease. A red cell distribution width greater than 15% had a sensitivity of 71% and a specificity of 54% for iron deficiency as diagnosed by a low serum ferritin or bone marrow examination. A mean corpuscular volume less than 80 femtoliters had a sensitivity of 53% and a specificity of 84%. Transferrin saturation less than 16% had a sensitivity of 61% and a specificity of 86%. Because the sensitivities and specificities of these tests are less than reported in studies of healthier populations, they cannot be relied on for screening for iron deficiency in sick hospitalized patients. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3178371/Red_cell_distribution_width_mean_corpuscular_volume_and_transferrin_saturation_in_the_diagnosis_of_iron_deficiency_ DB - PRIME DP - Unbound Medicine ER -