Tags

Type your tag names separated by a space and hit enter

Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature.
Pathol Res Pract 2019; :152750PR

Abstract

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical, and H3F3A (Histone H3.3) mutation analyses. A 59-year-old woman preoperatively diagnosed with DCIS underwent total mastectomy for a cystic mass. Histology revealed a tumor composed of mononuclear cells interspersed with numerous osteoclast-like giant cells, resembling giant cell tumor of bone (GCT-B), with apocrine DCIS in proximity to the tumor. The mononuclear and giant cells were immunoreactive for CD68 and negative for cytokeratins. Granulomatous diseases, carcinomas with giant cells, and giant cell-type sarcomas were excluded by histological and immunophenotypic features. Lack of H3F3A mutation eliminated the possibility of GCT-B metastasizing to the breast. These findings were consistent with GCT-ST of the breast. To our knowledge, this is the ninth reported case of breast GCT-ST, but the first case that accompanied DCIS or involved H3F3A mutation status investigation. For correct diagnosis of this rare tumor, it is important for pathologists to raise the possibility of GCT-ST when encountering giant cell-rich breast lesions and to exclude other differential diagnoses by combining the results of histological, immunohistochemical, and genetic analyses.

Authors+Show Affiliations

Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Department of Pathology, Cancer Center, Mittaphab Hospital, Vientiane, Lao People's Democratic Republic.Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan. Electronic address: tomo.osako@jfcr.or.jp.Breast Oncology Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Diagnostic Imaging Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Diagnostic Imaging Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Breast Oncology Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Breast Oncology Center, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Pathology, Kawakita General Hospital, Tokyo, Japan.Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Pathology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; Pathology Project for Molecular Targets, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31784095

Citation

Luangxay, Thitsamay, et al. "Giant Cell Tumor of Soft Tissue of the Breast: Case Report With H3F3A Mutation Analysis and Review of the Literature." Pathology, Research and Practice, 2019, p. 152750.
Luangxay T, Osako T, Yonekura R, et al. Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature. Pathol Res Pract. 2019.
Luangxay, T., Osako, T., Yonekura, R., Sugiura, Y., Kikuchi, M., Gomi, N., ... Akiyama, F. (2019). Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature. Pathology, Research and Practice, p. 152750. doi:10.1016/j.prp.2019.152750.
Luangxay T, et al. Giant Cell Tumor of Soft Tissue of the Breast: Case Report With H3F3A Mutation Analysis and Review of the Literature. Pathol Res Pract. 2019 Nov 19;152750. PubMed PMID: 31784095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature. AU - Luangxay,Thitsamay, AU - Osako,Tomo, AU - Yonekura,Rika, AU - Sugiura,Yoshiya, AU - Kikuchi,Mari, AU - Gomi,Naoya, AU - Ueno,Takayuki, AU - Ohno,Shinji, AU - Machinami,Rikuo, AU - Takeuchi,Kengo, AU - Akiyama,Futoshi, Y1 - 2019/11/19/ PY - 2019/09/23/received PY - 2019/11/14/revised PY - 2019/11/17/accepted PY - 2019/12/1/pubmed PY - 2019/12/1/medline PY - 2019/12/1/entrez KW - Cystic breast mass KW - Giant cell tumor of bone KW - Giant cell tumor of soft tissue KW - H3F3A mutation KW - Histone H3.3 KW - Primary breast tumor SP - 152750 EP - 152750 JF - Pathology, research and practice JO - Pathol. Res. Pract. N2 - Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical, and H3F3A (Histone H3.3) mutation analyses. A 59-year-old woman preoperatively diagnosed with DCIS underwent total mastectomy for a cystic mass. Histology revealed a tumor composed of mononuclear cells interspersed with numerous osteoclast-like giant cells, resembling giant cell tumor of bone (GCT-B), with apocrine DCIS in proximity to the tumor. The mononuclear and giant cells were immunoreactive for CD68 and negative for cytokeratins. Granulomatous diseases, carcinomas with giant cells, and giant cell-type sarcomas were excluded by histological and immunophenotypic features. Lack of H3F3A mutation eliminated the possibility of GCT-B metastasizing to the breast. These findings were consistent with GCT-ST of the breast. To our knowledge, this is the ninth reported case of breast GCT-ST, but the first case that accompanied DCIS or involved H3F3A mutation status investigation. For correct diagnosis of this rare tumor, it is important for pathologists to raise the possibility of GCT-ST when encountering giant cell-rich breast lesions and to exclude other differential diagnoses by combining the results of histological, immunohistochemical, and genetic analyses. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/31784095/Giant_cell_tumor_of_soft_tissue_of_the_breast:_Case_report_with_H3F3A_mutation_analysis_and_review_of_the_literature L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(19)32069-2 DB - PRIME DP - Unbound Medicine ER -