Tags

Type your tag names separated by a space and hit enter

Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques.

Abstract

Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure.

Authors+Show Affiliations

Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil.Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.Department of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil.Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil.Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: ayala@fisica.ufc.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31785240

Citation

Alves de Santana, Maria Silmara, et al. "Stability of Ceftazidime Pentahydrate Investigated By Thermal Analysis Techniques." Journal of Pharmaceutical Sciences, 2019.
Alves de Santana MS, Santiago de Oliveira Y, de Castro Fonseca J, et al. Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques. J Pharm Sci. 2019.
Alves de Santana, M. S., Santiago de Oliveira, Y., de Castro Fonseca, J., Ferreira, W. C., Neto, V. S., & Ayala, A. P. (2019). Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques. Journal of Pharmaceutical Sciences, doi:10.1016/j.xphs.2019.11.018.
Alves de Santana MS, et al. Stability of Ceftazidime Pentahydrate Investigated By Thermal Analysis Techniques. J Pharm Sci. 2019 Nov 27; PubMed PMID: 31785240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques. AU - Alves de Santana,Maria Silmara, AU - Santiago de Oliveira,Yara, AU - de Castro Fonseca,Jéssica, AU - Ferreira,Wellington Castro, AU - Neto,Vasco Stascxak, AU - Ayala,Alejandro Pedro, Y1 - 2019/11/27/ PY - 2019/07/09/received PY - 2019/11/05/revised PY - 2019/11/19/accepted PY - 2019/12/1/pubmed PY - 2019/12/1/medline PY - 2019/12/1/entrez KW - ceftazidime pentahydrate KW - cephalosporin KW - stability KW - thermal analysis JF - Journal of pharmaceutical sciences JO - J Pharm Sci N2 - Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/31785240/Stability_of_Ceftazidime_Pentahydrate_investigated_by_Thermal_Analysis_Techniques L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(19)30798-1 DB - PRIME DP - Unbound Medicine ER -