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Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane implant in partial breast brachytherapy.

Abstract

PURPOSE

Partial-breast irradiation (PBI) using multicatheter-interstitial brachytherapy (MIB) has been supported by some randomized trials to date. However, it remains underutilized in Asian countries because of the population's typically smaller breasts. Single-plane implantation has been recommended in these individuals, but limited data on the clinical efficacy exist. We performed a retrospective chart review to compare the tumor control and long-term cosmesis in patients treated with the single-plane implant technique.

MATERIAL AND METHODS

Patients receiving MIB-PBI between October 2008 and December 2018 were evaluated. PBI was initiated on the same day of the surgery via an intraoperative catheter implant, delivering 32 Gy by eight fractions. Tumor control based on the rate of freedom from ipsilateral tumor recurrence (IBTR) and disease-free survival and long-term cosmesis using the Harvard scale were evaluated to compare between the single- and double-/triple-plane implant techniques.

RESULTS

Five hundred sixteen patients with 526 lesions received MIB-PBI with a median follow-up of 53.1 months. Patients treated by single- and double-/triple-plane implant numbered 288 (54.8%) and 238 (45.2%), respectively. The four-year probabilities of IBTR-free survival and disease-free survival were 97.5% and 96.5% in single-plane implant and 98.6% (p = 0.42) and 98.0% (p = 0.18) in double-/triple-plane implant MIB-PBI, respectively. Although young age (p < 0.05) and positive surgical margins (p < 0.01) were selected as independent risk factors for IBTR, single-plane implantation was not recognized as a risk factor of IBTR. Sixty-one of 69 single-plane implant patients (88.4%) and 84 of 92 double-/triple-plane implant patients (91.3%) reported excellent to good cosmetic results (p = 0.73).

DISCUSSION

Although this was a retrospective study from a single institution and cosmesis was evaluated using a subjective method, this is the first report to validate single-plane implant MIB-PBI for use in small-breasted patients. Further multicenter research is required.

Authors+Show Affiliations

Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo 196-0003, Japan. Electronic address: kazsato.boc@gmail.com.Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo 196-0003, Japan. Electronic address: a141219@yahoo.co.jp.Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo 196-0003, Japan. Electronic address: pinoko-naoko@hotmail.co.jp.Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo 196-0003, Japan. Electronic address: shimo@shore.ocn.ne.jp.Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo 196-0003, Japan. Electronic address: raijinnpower@yahoo.co.jp.Preventive Medical Center, Sano City Hospital, 1832-1 Tanuma, Sano, Tochigi 327-0317, Japan. Electronic address: tomohikookawamail@yahoo.co.jp.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31785336

Citation

Sato, Kazuhiko, et al. "Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane Implant in Partial Breast Brachytherapy." International Journal of Radiation Oncology, Biology, Physics, 2019.
Sato K, Fuchikami H, Takeda N, et al. Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane implant in partial breast brachytherapy. Int J Radiat Oncol Biol Phys. 2019.
Sato, K., Fuchikami, H., Takeda, N., Shimo, T., Kato, M., & Okawa, T. (2019). Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane implant in partial breast brachytherapy. International Journal of Radiation Oncology, Biology, Physics, doi:10.1016/j.ijrobp.2019.11.024.
Sato K, et al. Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane Implant in Partial Breast Brachytherapy. Int J Radiat Oncol Biol Phys. 2019 Nov 27; PubMed PMID: 31785336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Single-plane Implant Technique in Partial Breast Brachytherapy in Small-breasted Patients: Single-plane implant in partial breast brachytherapy. AU - Sato,Kazuhiko, AU - Fuchikami,Hiromi, AU - Takeda,Naoko, AU - Shimo,Takahiro, AU - Kato,Masahiro, AU - Okawa,Tomohiko, Y1 - 2019/11/27/ PY - 2019/09/11/received PY - 2019/11/11/revised PY - 2019/11/17/accepted PY - 2019/12/1/entrez PY - 2019/12/1/pubmed PY - 2019/12/1/medline KW - Breast cancer KW - Breast-conserving therapy KW - Multicatheter-interstitial brachytherapy KW - Partial-breast irradiation JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. N2 - PURPOSE: Partial-breast irradiation (PBI) using multicatheter-interstitial brachytherapy (MIB) has been supported by some randomized trials to date. However, it remains underutilized in Asian countries because of the population's typically smaller breasts. Single-plane implantation has been recommended in these individuals, but limited data on the clinical efficacy exist. We performed a retrospective chart review to compare the tumor control and long-term cosmesis in patients treated with the single-plane implant technique. MATERIAL AND METHODS: Patients receiving MIB-PBI between October 2008 and December 2018 were evaluated. PBI was initiated on the same day of the surgery via an intraoperative catheter implant, delivering 32 Gy by eight fractions. Tumor control based on the rate of freedom from ipsilateral tumor recurrence (IBTR) and disease-free survival and long-term cosmesis using the Harvard scale were evaluated to compare between the single- and double-/triple-plane implant techniques. RESULTS: Five hundred sixteen patients with 526 lesions received MIB-PBI with a median follow-up of 53.1 months. Patients treated by single- and double-/triple-plane implant numbered 288 (54.8%) and 238 (45.2%), respectively. The four-year probabilities of IBTR-free survival and disease-free survival were 97.5% and 96.5% in single-plane implant and 98.6% (p = 0.42) and 98.0% (p = 0.18) in double-/triple-plane implant MIB-PBI, respectively. Although young age (p < 0.05) and positive surgical margins (p < 0.01) were selected as independent risk factors for IBTR, single-plane implantation was not recognized as a risk factor of IBTR. Sixty-one of 69 single-plane implant patients (88.4%) and 84 of 92 double-/triple-plane implant patients (91.3%) reported excellent to good cosmetic results (p = 0.73). DISCUSSION: Although this was a retrospective study from a single institution and cosmesis was evaluated using a subjective method, this is the first report to validate single-plane implant MIB-PBI for use in small-breasted patients. Further multicenter research is required. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/31785336/Efficacy_of_Single-plane_Implant_Technique_in_Partial_Breast_Brachytherapy_in_Small-breasted_Patients:_Single-plane_implant_in_partial_breast_brachytherapy L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(19)34060-X DB - PRIME DP - Unbound Medicine ER -