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Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women.
Breast 2019; 49:108-114B

Abstract

BACKGROUND

Compared to U.S. white women, African American women are more likely to die from ductal carcinoma in situ (DCIS). Elucidation of risk factors for DCIS in African American women may provide opportunities for risk reduction.

METHODS

We used data from three epidemiologic studies in the African American Breast Cancer Epidemiology and Risk Consortium to study risk factors for estrogen receptor (ER) positive DCIS (488 cases; 13,830 controls). Results were compared to associations observed for ER+ invasive breast cancer (n = 2,099).

RESULTS

First degree family history of breast cancer was associated with increased risk of ER+ DCIS [odds ratio (OR): 1.69, 95% confidence interval (CI): 1.31, 2.17]. Oral contraceptive use within the past 10 years (vs. never) was also associated with increased risk (OR: 1.43, 95%CI: 1.03, 1.97), as was late age at first birth (≥25 years vs. <20 years) (OR: 1.26, 95%CI: 0.96, 1.67). Risk was reduced in women with older age at menarche (≥15 years vs. <11 years) (OR: 0.62, 95%CI: 0.42, 0.93) and higher body mass index (BMI) in early adulthood (≥25 vs. <20 kg/m2 at age 18 or 21) (OR: 0.75, 95%CI: 0.55, 1.01). There was a positive association of recent BMI with risk in postmenopausal women only. In general, associations of risk factors for ER+ DCIS were similar in magnitude and direction to those for invasive ER+ breast cancer.

CONCLUSIONS

Our findings suggest that most risk factors for invasive ER+ breast cancer are also associated with increased risk of ER+ DCIS among African American women.

Authors+Show Affiliations

Slone Epidemiology Center at Boston University, Boscton, MA, USA. Electronic address: kab15@bu.edu.Slone Epidemiology Center at Boston University, Boscton, MA, USA.Slone Epidemiology Center at Boston University, Boscton, MA, USA.Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.Roswell Park Cancer Institute, Buffalo, NY, USA.Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.Roswell Park Cancer Institute, Buffalo, NY, USA.Slone Epidemiology Center at Boston University, Boscton, MA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31786415

Citation

Bertrand, Kimberly A., et al. "Risk Factors for Estrogen Receptor Positive Ductal Carcinoma in Situ of the Breast in African American Women." Breast (Edinburgh, Scotland), vol. 49, 2019, pp. 108-114.
Bertrand KA, Bethea TN, Rosenberg L, et al. Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women. Breast. 2019;49:108-114.
Bertrand, K. A., Bethea, T. N., Rosenberg, L., Bandera, E. V., Khoury, T., Troester, M. A., ... Palmer, J. R. (2019). Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women. Breast (Edinburgh, Scotland), 49, pp. 108-114. doi:10.1016/j.breast.2019.10.009.
Bertrand KA, et al. Risk Factors for Estrogen Receptor Positive Ductal Carcinoma in Situ of the Breast in African American Women. Breast. 2019 Nov 6;49:108-114. PubMed PMID: 31786415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for estrogen receptor positive ductal carcinoma in situ of the breast in African American women. AU - Bertrand,Kimberly A, AU - Bethea,Traci N, AU - Rosenberg,Lynn, AU - Bandera,Elisa V, AU - Khoury,Thaer, AU - Troester,Melissa A, AU - Ambrosone,Christine B, AU - Palmer,Julie R, Y1 - 2019/11/06/ PY - 2019/09/03/received PY - 2019/10/15/revised PY - 2019/10/21/accepted PY - 2019/12/2/pubmed PY - 2019/12/2/medline PY - 2019/12/2/entrez KW - African American KW - Breast cancer KW - Ductal carcinoma in situ KW - Epidemiology KW - Risk factors SP - 108 EP - 114 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 49 N2 - BACKGROUND: Compared to U.S. white women, African American women are more likely to die from ductal carcinoma in situ (DCIS). Elucidation of risk factors for DCIS in African American women may provide opportunities for risk reduction. METHODS: We used data from three epidemiologic studies in the African American Breast Cancer Epidemiology and Risk Consortium to study risk factors for estrogen receptor (ER) positive DCIS (488 cases; 13,830 controls). Results were compared to associations observed for ER+ invasive breast cancer (n = 2,099). RESULTS: First degree family history of breast cancer was associated with increased risk of ER+ DCIS [odds ratio (OR): 1.69, 95% confidence interval (CI): 1.31, 2.17]. Oral contraceptive use within the past 10 years (vs. never) was also associated with increased risk (OR: 1.43, 95%CI: 1.03, 1.97), as was late age at first birth (≥25 years vs. <20 years) (OR: 1.26, 95%CI: 0.96, 1.67). Risk was reduced in women with older age at menarche (≥15 years vs. <11 years) (OR: 0.62, 95%CI: 0.42, 0.93) and higher body mass index (BMI) in early adulthood (≥25 vs. <20 kg/m2 at age 18 or 21) (OR: 0.75, 95%CI: 0.55, 1.01). There was a positive association of recent BMI with risk in postmenopausal women only. In general, associations of risk factors for ER+ DCIS were similar in magnitude and direction to those for invasive ER+ breast cancer. CONCLUSIONS: Our findings suggest that most risk factors for invasive ER+ breast cancer are also associated with increased risk of ER+ DCIS among African American women. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/31786415/Risk_factors_for_estrogen_receptor_positive_ductal_carcinoma_in_situ_of_the_breast_in_African_American_women L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(19)30580-6 DB - PRIME DP - Unbound Medicine ER -