Tags

Type your tag names separated by a space and hit enter

Longitudinal Effects of Cigarette Smoking and Smoking Cessation on Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility.
J Am Heart Assoc 2019; 8(24):e013939JA

Abstract

Background We evaluated the effects of smoking and smoking cessation on aortic wave reflections (augmentation index), aortic pulse wave velocity, and carotid artery distensibility and stiffness (distensibility coefficient, Young's elastic modulus). Methods and Results Current smokers underwent carotid, radial, and femoral artery tonometry and carotid ultrasound at baseline and 3 years after a quit attempt. Baseline associations of smoking heaviness markers (exhaled carbon monoxide and cigarettes smoked/d) and effects of smoking cessation at year 3 on changes in arterial measures were assessed using multivariable linear regression models. The 1417 smokers (54% female) were mean (SD) 49.3 (11.6) years old and smoked 17.2 (8.3) cigarettes/d (exhaled carbon monoxide 14.7 [8.2] parts per million). Arterial measures were associated more strongly with age, blood pressure (BP), and waist circumference than with smoking heaviness markers. Augmentation index was associated independently with carbon monoxide (P=0.004). Pulse wave velocity, distensibility coefficient, and Young's elastic modulus had small, inconsistent associations with smoking heaviness markers. At year 3, augmentation index improved with smoking cessation (P=0.006) despite more weight gain (2.54 vs 0.36 kg, P<0.001) and insulin resistance (P=0.001) among abstainers, but distensibility coefficient decreased (P=0.004). Changes in arterial measures were related more strongly to changes in BP than smoking cessation. Conclusions Arterial wave reflection and stiffness measures were associated more strongly with age, BP, and waist circumference than smoking heaviness. Smoking cessation was associated with weight gain and increased insulin resistance. Changes in arterial measures were predicted by changes in BP, highlighting the need to address weight gain and BP changes during a quit attempt.

Authors+Show Affiliations

School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.School of Medicine and Public Health University of Wisconsin Madison WI.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31795823

Citation

Schmidt, Kelly M T., et al. "Longitudinal Effects of Cigarette Smoking and Smoking Cessation On Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility." Journal of the American Heart Association, vol. 8, no. 24, 2019, pp. e013939.
Schmidt KMT, Hansen KM, Johnson AL, et al. Longitudinal Effects of Cigarette Smoking and Smoking Cessation on Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility. J Am Heart Assoc. 2019;8(24):e013939.
Schmidt, K. M. T., Hansen, K. M., Johnson, A. L., Gepner, A. D., Korcarz, C. E., Fiore, M. C., ... Stein, J. H. (2019). Longitudinal Effects of Cigarette Smoking and Smoking Cessation on Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility. Journal of the American Heart Association, 8(24), pp. e013939. doi:10.1161/JAHA.119.013939.
Schmidt KMT, et al. Longitudinal Effects of Cigarette Smoking and Smoking Cessation On Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility. J Am Heart Assoc. 2019 Dec 17;8(24):e013939. PubMed PMID: 31795823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal Effects of Cigarette Smoking and Smoking Cessation on Aortic Wave Reflections, Pulse Wave Velocity, and Carotid Artery Distensibility. AU - Schmidt,Kelly M T, AU - Hansen,Kristin M, AU - Johnson,Adrienne L, AU - Gepner,Adam D, AU - Korcarz,Claudia E, AU - Fiore,Michael C, AU - Baker,Timothy B, AU - Piper,Megan E, AU - Stein,James H, Y1 - 2019/12/04/ PY - 2019/12/5/entrez PY - 2019/12/5/pubmed PY - 2019/12/5/medline KW - arterial stiffness KW - blood pressure KW - smoking SP - e013939 EP - e013939 JF - Journal of the American Heart Association JO - J Am Heart Assoc VL - 8 IS - 24 N2 - Background We evaluated the effects of smoking and smoking cessation on aortic wave reflections (augmentation index), aortic pulse wave velocity, and carotid artery distensibility and stiffness (distensibility coefficient, Young's elastic modulus). Methods and Results Current smokers underwent carotid, radial, and femoral artery tonometry and carotid ultrasound at baseline and 3 years after a quit attempt. Baseline associations of smoking heaviness markers (exhaled carbon monoxide and cigarettes smoked/d) and effects of smoking cessation at year 3 on changes in arterial measures were assessed using multivariable linear regression models. The 1417 smokers (54% female) were mean (SD) 49.3 (11.6) years old and smoked 17.2 (8.3) cigarettes/d (exhaled carbon monoxide 14.7 [8.2] parts per million). Arterial measures were associated more strongly with age, blood pressure (BP), and waist circumference than with smoking heaviness markers. Augmentation index was associated independently with carbon monoxide (P=0.004). Pulse wave velocity, distensibility coefficient, and Young's elastic modulus had small, inconsistent associations with smoking heaviness markers. At year 3, augmentation index improved with smoking cessation (P=0.006) despite more weight gain (2.54 vs 0.36 kg, P<0.001) and insulin resistance (P=0.001) among abstainers, but distensibility coefficient decreased (P=0.004). Changes in arterial measures were related more strongly to changes in BP than smoking cessation. Conclusions Arterial wave reflection and stiffness measures were associated more strongly with age, BP, and waist circumference than smoking heaviness. Smoking cessation was associated with weight gain and increased insulin resistance. Changes in arterial measures were predicted by changes in BP, highlighting the need to address weight gain and BP changes during a quit attempt. SN - 2047-9980 UR - https://www.unboundmedicine.com/medline/citation/31795823/Longitudinal_Effects_of_Cigarette_Smoking_and_Smoking_Cessation_on_Aortic_Wave_Reflections,_Pulse_Wave_Velocity,_and_Carotid_Artery_Distensibility L2 - http://www.ahajournals.org/doi/full/10.1161/JAHA.119.013939?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -