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Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study.
Front Integr Neurosci 2019; 13:67FI

Abstract

Semantic audiovisual stimuli have a facilitatory effect on behavioral performance and influence the integration of multisensory inputs across sensory modalities. Many neuroimaging and electrophysiological studies investigated the neural mechanisms of multisensory semantic processing and reported that attention modulates the response to multisensory semantic inputs. In the present study, we designed an functional magnetic resonance imaging (fMRI) experiment of semantic discrimination using the unimodal auditory, unimodal visual and bimodal audiovisual stimuli with semantic information. By manipulating the stimuli present on attended and unattended position, we recorded the task-related fMRI data corresponding to the unimodal auditory, unimodal visual and bimodal audiovisual stimuli in attended and unattended conditions. We also recorded the fMRI data in resting state. Then the fMRI method was used together with a graph theoretical analysis to construct the functional brain networks in task-related and resting states and quantitatively characterize the topological network properties. The aim of our present study is to explore the characteristics of functional brain networks that process semantic audiovisual stimuli in attended and unattended conditions, revealing the neural mechanism of multisensory processing and the modulation of attention. The behavioral results showed that the audiovisual stimulus presented simultaneously promoted the performance of semantic discrimination task. And the analyses of network properties showed that compared with the resting-state condition, the functional networks of processing semantic audiovisual stimuli (both in attended and unattended conditions) had greater small-worldness, global efficiency, and lower clustering coefficient, characteristic path length, global efficiency and hierarchy. In addition, the hubs were concentrated in the bilateral temporal lobes, especially in the anterior temporal lobes (ATLs), which were positively correlated to reaction time (RT). Moreover, attention significantly altered the degree of small-worldness and the distribution of hubs in the functional network for processing semantic audiovisual stimuli. Our findings suggest that the topological structure of the functional brain network for processing semantic audiovisual stimulus is modulated by attention, and has the characteristics of high efficiency and low wiring cost, which maintains an optimized balance between functional segregation and integration for multisensory processing efficiently.

Authors+Show Affiliations

School of Computer Science and Technology, Changchun University of Science and Technology, Changchun, China. School of Computer Science, Northeast Electric Power University, Jilin, China.School of Computer Science and Technology, Changchun University of Science and Technology, Changchun, China.Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.Department of Neurology, The First Hospital of Jilin University, Changchun, China.Department of Neurology, The First Hospital of Jilin University, Changchun, China.Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31798426

Citation

Xi, Yang, et al. "Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: a Graph-Based Study." Frontiers in Integrative Neuroscience, vol. 13, 2019, p. 67.
Xi Y, Li Q, Zhang M, et al. Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study. Front Integr Neurosci. 2019;13:67.
Xi, Y., Li, Q., Zhang, M., Liu, L., Li, G., Lin, W., & Wu, J. (2019). Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study. Frontiers in Integrative Neuroscience, 13, p. 67. doi:10.3389/fnint.2019.00067.
Xi Y, et al. Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: a Graph-Based Study. Front Integr Neurosci. 2019;13:67. PubMed PMID: 31798426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimized Configuration of Functional Brain Network for Processing Semantic Audiovisual Stimuli Underlying the Modulation of Attention: A Graph-Based Study. AU - Xi,Yang, AU - Li,Qi, AU - Zhang,Mengchao, AU - Liu,Lin, AU - Li,Guangjian, AU - Lin,Weihong, AU - Wu,Jinglong, Y1 - 2019/11/19/ PY - 2019/07/03/received PY - 2019/11/05/accepted PY - 2019/12/5/entrez PY - 2019/12/5/pubmed PY - 2019/12/5/medline KW - audiovisual stimulus KW - brain network KW - functional connectivity KW - functional magnetic resonance imaging KW - graph theory KW - semantics SP - 67 EP - 67 JF - Frontiers in integrative neuroscience JO - Front Integr Neurosci VL - 13 N2 - Semantic audiovisual stimuli have a facilitatory effect on behavioral performance and influence the integration of multisensory inputs across sensory modalities. Many neuroimaging and electrophysiological studies investigated the neural mechanisms of multisensory semantic processing and reported that attention modulates the response to multisensory semantic inputs. In the present study, we designed an functional magnetic resonance imaging (fMRI) experiment of semantic discrimination using the unimodal auditory, unimodal visual and bimodal audiovisual stimuli with semantic information. By manipulating the stimuli present on attended and unattended position, we recorded the task-related fMRI data corresponding to the unimodal auditory, unimodal visual and bimodal audiovisual stimuli in attended and unattended conditions. We also recorded the fMRI data in resting state. Then the fMRI method was used together with a graph theoretical analysis to construct the functional brain networks in task-related and resting states and quantitatively characterize the topological network properties. The aim of our present study is to explore the characteristics of functional brain networks that process semantic audiovisual stimuli in attended and unattended conditions, revealing the neural mechanism of multisensory processing and the modulation of attention. The behavioral results showed that the audiovisual stimulus presented simultaneously promoted the performance of semantic discrimination task. And the analyses of network properties showed that compared with the resting-state condition, the functional networks of processing semantic audiovisual stimuli (both in attended and unattended conditions) had greater small-worldness, global efficiency, and lower clustering coefficient, characteristic path length, global efficiency and hierarchy. In addition, the hubs were concentrated in the bilateral temporal lobes, especially in the anterior temporal lobes (ATLs), which were positively correlated to reaction time (RT). Moreover, attention significantly altered the degree of small-worldness and the distribution of hubs in the functional network for processing semantic audiovisual stimuli. Our findings suggest that the topological structure of the functional brain network for processing semantic audiovisual stimulus is modulated by attention, and has the characteristics of high efficiency and low wiring cost, which maintains an optimized balance between functional segregation and integration for multisensory processing efficiently. SN - 1662-5145 UR - https://www.unboundmedicine.com/medline/citation/31798426/Optimized_Configuration_of_Functional_Brain_Network_for_Processing_Semantic_Audiovisual_Stimuli_Underlying_the_Modulation_of_Attention:_A_Graph-Based_Study L2 - https://doi.org//10.3389/fnint.2019.00067 DB - PRIME DP - Unbound Medicine ER -