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Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes.
Rev Bras Parasitol Vet 2019 Oct-Dec; 28(4):644-651RB

Abstract

This study aimed to evaluate the anthelmintic activity of Eucalyptus citriodora essential oil and citronellal on sheep gastrointestinal nematodes. Essential oil composition was determined by gas chromatography mass spectrometry. The substances were evaluated in vitro using adult worm motility test (AWMT) and transmission electron microscopy (TEM). The acute toxicity test in mice and the fecal egg count reduction test (FECRT) in sheep were performed. Citronellal was confirmed as the essential oil major constituent (63.9%). According to the AWMT, 2 mg/mL of essential oil and citronellal completely inhibited Haemonchus contortus motility at 6 h post exposure. H. contortus exposed to essential oil and citronellal exhibited internal ultrastructural modifications. The lethal dose 50 values in mice were 5,000 and 2,609 mg/kg for essential oil and citronellal, respectively. E. citriodora essential oil reduced sheep epg at 14 days post treatment by 69.5% (P<0.05). No significant differences were observed in epg between the citronellal and negative control groups (P>0.05). The interaction between citronellal and other constituents in the essential oil may be relevant for its in vivo anthelmintic activity. Thus, E. citriodora essential oil and citronellal pharmacokinetic studies may help elucidate the anthelmintic activity of these compounds.

Authors+Show Affiliations

Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará - UFC, Fortaleza, CE, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Química de Produtos Naturais, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense - Darcy Ribeiro, Campos dos Goytacazes, RJ, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Química de Produtos Naturais, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.Laboratório de Doenças Parasitárias, Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará - UECE, Fortaleza, CE, Brasil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31800886

Citation

Araújo-Filho, José Vilemar de, et al. "Anthelmintic Activity of Eucalyptus Citriodora Essential Oil and Its Major Component, Citronellal, On Sheep Gastrointestinal Nematodes." Revista Brasileira De Parasitologia Veterinaria = Brazilian Journal of Veterinary Parasitology : Orgao Oficial Do Colegio Brasileiro De Parasitologia Veterinaria, vol. 28, no. 4, 2019, pp. 644-651.
Araújo-Filho JV, Ribeiro WLC, André WPP, et al. Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes. Rev Bras Parasitol Vet. 2019;28(4):644-651.
Araújo-Filho, J. V., Ribeiro, W. L. C., André, W. P. P., Cavalcante, G. S., Rios, T. T., Schwinden, G. M., ... Oliveira, L. M. B. (2019). Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes. Revista Brasileira De Parasitologia Veterinaria = Brazilian Journal of Veterinary Parasitology : Orgao Oficial Do Colegio Brasileiro De Parasitologia Veterinaria, 28(4), pp. 644-651. doi:10.1590/S1984-29612019090.
Araújo-Filho JV, et al. Anthelmintic Activity of Eucalyptus Citriodora Essential Oil and Its Major Component, Citronellal, On Sheep Gastrointestinal Nematodes. Rev Bras Parasitol Vet. 2019;28(4):644-651. PubMed PMID: 31800886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes. AU - Araújo-Filho,José Vilemar de, AU - Ribeiro,Wesley Lyeverton Correia, AU - André,Weibson Paz Pinheiro, AU - Cavalcante,Géssica Soares, AU - Rios,Thays Tabosa, AU - Schwinden,Gabriela Maria, AU - Rocha,Letícia Oliveira da, AU - Macedo,Iara Tersia Freitas, AU - Morais,Selene Maia de, AU - Bevilaqua,Claudia Maria Leal, AU - Oliveira,Lorena Mayana Beserra de, PY - 2019/05/29/received PY - 2019/09/13/accepted PY - 2019/12/5/entrez PY - 2019/12/5/pubmed PY - 2019/12/5/medline SP - 644 EP - 651 JF - Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria JO - Rev Bras Parasitol Vet VL - 28 IS - 4 N2 - This study aimed to evaluate the anthelmintic activity of Eucalyptus citriodora essential oil and citronellal on sheep gastrointestinal nematodes. Essential oil composition was determined by gas chromatography mass spectrometry. The substances were evaluated in vitro using adult worm motility test (AWMT) and transmission electron microscopy (TEM). The acute toxicity test in mice and the fecal egg count reduction test (FECRT) in sheep were performed. Citronellal was confirmed as the essential oil major constituent (63.9%). According to the AWMT, 2 mg/mL of essential oil and citronellal completely inhibited Haemonchus contortus motility at 6 h post exposure. H. contortus exposed to essential oil and citronellal exhibited internal ultrastructural modifications. The lethal dose 50 values in mice were 5,000 and 2,609 mg/kg for essential oil and citronellal, respectively. E. citriodora essential oil reduced sheep epg at 14 days post treatment by 69.5% (P<0.05). No significant differences were observed in epg between the citronellal and negative control groups (P>0.05). The interaction between citronellal and other constituents in the essential oil may be relevant for its in vivo anthelmintic activity. Thus, E. citriodora essential oil and citronellal pharmacokinetic studies may help elucidate the anthelmintic activity of these compounds. SN - 1984-2961 UR - https://www.unboundmedicine.com/medline/citation/31800886/Anthelmintic_activity_of_Eucalyptus_citriodora_essential_oil_and_its_major_component,_citronellal,_on_sheep_gastrointestinal_nematodes L2 - http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1984-29612019000400644&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -