Tags

Type your tag names separated by a space and hit enter

The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family.
Cell Rep 2019; 29(10):2961-2969.e6CR

Abstract

Many tumor viruses encode oncogenes of cellular origin. Here, we report an oncoviral mimic of a cellular tumor suppressor. The Kaposi's sarcoma-associated herpesvirus (KSHV) microRNA (miRNA) miR-K6-5p shares sequence similarity to the tumor-suppressive cellular miR-15/16 miRNA family. We show that miR-K6-5p inhibits cell cycle progression, a hallmark function of miR-16. miR-K6-5p regulates conserved miR-15/16 family miRNA targets, including many cell cycle regulators. Inhibition of miR-K6-5p in KSHV-transformed B cells confers a significant growth advantage. Altogether, our data show that KSHV encodes a functional mimic of miR-15/16 family miRNAs. While it is exceedingly well established that oncogenic viruses encode oncogenes of cellular origin, this is an unusual example of an oncogenic virus that encodes a viral mimic of a cellular tumor suppressor. Encoding a tumor-suppressive miRNA could help KSHV balance viral oncogene expression and thereby avoid severe pathogenesis in the healthy host.

Authors+Show Affiliations

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: e-gottwein@northwestern.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31801064

Citation

Morrison, Kylee, et al. "The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family." Cell Reports, vol. 29, no. 10, 2019, pp. 2961-2969.e6.
Morrison K, Manzano M, Chung K, et al. The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Rep. 2019;29(10):2961-2969.e6.
Morrison, K., Manzano, M., Chung, K., Schipma, M. J., Bartom, E. T., & Gottwein, E. (2019). The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Reports, 29(10), pp. 2961-2969.e6. doi:10.1016/j.celrep.2019.11.005.
Morrison K, et al. The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Rep. 2019 Dec 3;29(10):2961-2969.e6. PubMed PMID: 31801064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. AU - Morrison,Kylee, AU - Manzano,Mark, AU - Chung,Kevin, AU - Schipma,Matthew J, AU - Bartom,Elizabeth T, AU - Gottwein,Eva, PY - 2019/06/10/received PY - 2019/10/07/revised PY - 2019/11/01/accepted PY - 2019/12/5/entrez PY - 2019/12/5/pubmed PY - 2019/12/5/medline KW - KSHV KW - miR-15/16 KW - microRNA KW - tumor virus SP - 2961 EP - 2969.e6 JF - Cell reports JO - Cell Rep VL - 29 IS - 10 N2 - Many tumor viruses encode oncogenes of cellular origin. Here, we report an oncoviral mimic of a cellular tumor suppressor. The Kaposi's sarcoma-associated herpesvirus (KSHV) microRNA (miRNA) miR-K6-5p shares sequence similarity to the tumor-suppressive cellular miR-15/16 miRNA family. We show that miR-K6-5p inhibits cell cycle progression, a hallmark function of miR-16. miR-K6-5p regulates conserved miR-15/16 family miRNA targets, including many cell cycle regulators. Inhibition of miR-K6-5p in KSHV-transformed B cells confers a significant growth advantage. Altogether, our data show that KSHV encodes a functional mimic of miR-15/16 family miRNAs. While it is exceedingly well established that oncogenic viruses encode oncogenes of cellular origin, this is an unusual example of an oncogenic virus that encodes a viral mimic of a cellular tumor suppressor. Encoding a tumor-suppressive miRNA could help KSHV balance viral oncogene expression and thereby avoid severe pathogenesis in the healthy host. SN - 2211-1247 UR - https://www.unboundmedicine.com/medline/citation/31801064/The_Oncogenic_Kaposi's_Sarcoma-Associated_Herpesvirus_Encodes_a_Mimic_of_the_Tumor-Suppressive_miR-15/16_miRNA_Family L2 - https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(19)31476-7 DB - PRIME DP - Unbound Medicine ER -