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Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases.
Int J Mol Sci. 2019 Nov 30; 20(23)IJ

Abstract

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases neuronal vulnerability to cellular stress and may contribute to the development and progression of neurodegenerative diseases. All major neurodegenerative disorders are also associated with oxidative stress, which is widely recognized as a potential target for protective therapies. Albeit often considered separately, microRNA networks and oxidative stress are inextricably entwined in neurodegenerative processes. Oxidative stress affects expression levels of multiple microRNAs and, conversely, microRNAs regulate many genes involved in an oxidative stress response. Both oxidative stress and microRNA regulatory networks also influence other processes linked to neurodegeneration, such as mitochondrial dysfunction, deregulation of proteostasis, and increased neuroinflammation, which ultimately lead to neuronal death. Modulating the levels of a relatively small number of microRNAs may therefore alleviate pathological oxidative damage and have neuroprotective activity. Here, we review the role of individual microRNAs in oxidative stress and related pathways in four neurodegenerative conditions: Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) disease, and amyotrophic lateral sclerosis (ALS). We also discuss the problems associated with the use of oversimplified cellular models and highlight perspectives of studying microRNA regulation and oxidative stress in human stem cell-derived neurons.

Authors+Show Affiliations

Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland.Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland. Institute of Molecular Biology and Genetics, NASU, Kyiv 03143, Ukraine.Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland.Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Krakow, Poland.Institute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31801298

Citation

Konovalova, Julia, et al. "Interplay Between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 20, no. 23, 2019.
Konovalova J, Gerasymchuk D, Parkkinen I, et al. Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. Int J Mol Sci. 2019;20(23).
Konovalova, J., Gerasymchuk, D., Parkkinen, I., Chmielarz, P., & Domanskyi, A. (2019). Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. International Journal of Molecular Sciences, 20(23). https://doi.org/10.3390/ijms20236055
Konovalova J, et al. Interplay Between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. Int J Mol Sci. 2019 Nov 30;20(23) PubMed PMID: 31801298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. AU - Konovalova,Julia, AU - Gerasymchuk,Dmytro, AU - Parkkinen,Ilmari, AU - Chmielarz,Piotr, AU - Domanskyi,Andrii, Y1 - 2019/11/30/ PY - 2019/10/28/received PY - 2019/11/23/revised PY - 2019/11/28/accepted PY - 2019/12/6/entrez PY - 2019/12/6/pubmed PY - 2020/4/17/medline KW - ALS KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - ROS KW - microRNA KW - neurodegeneration KW - oxidative stress KW - translation regulation JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 23 N2 - MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases neuronal vulnerability to cellular stress and may contribute to the development and progression of neurodegenerative diseases. All major neurodegenerative disorders are also associated with oxidative stress, which is widely recognized as a potential target for protective therapies. Albeit often considered separately, microRNA networks and oxidative stress are inextricably entwined in neurodegenerative processes. Oxidative stress affects expression levels of multiple microRNAs and, conversely, microRNAs regulate many genes involved in an oxidative stress response. Both oxidative stress and microRNA regulatory networks also influence other processes linked to neurodegeneration, such as mitochondrial dysfunction, deregulation of proteostasis, and increased neuroinflammation, which ultimately lead to neuronal death. Modulating the levels of a relatively small number of microRNAs may therefore alleviate pathological oxidative damage and have neuroprotective activity. Here, we review the role of individual microRNAs in oxidative stress and related pathways in four neurodegenerative conditions: Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) disease, and amyotrophic lateral sclerosis (ALS). We also discuss the problems associated with the use of oversimplified cellular models and highlight perspectives of studying microRNA regulation and oxidative stress in human stem cell-derived neurons. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/31801298/Interplay_between_MicroRNAs_and_Oxidative_Stress_in_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=ijms20236055 DB - PRIME DP - Unbound Medicine ER -