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A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio.
Cureus 2019; 11(10):e5965C

Abstract

Objective Laboratory analysis results may provide an opportunity to predict the activity process of recurrent aphthous stomatitis. The goal of this study was to investigate whether there is a correlation between C-reactive protein to albumin ratio (CAR) and oral ulcer activity in patients with recurrent aphthous stomatitis. Materials and methods We included 72 patients (39 with active and 33 with inactive lesion) with recurrent aphthous stomatitis and 60 healthy controls. We compared blood test parameters including CAR, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) among the groups. Additionally, we investigated the most significant parameter for the activity of oral ulcers. Results NLR was significantly higher both in the active (p<0.001) and inactive lesion groups (p<0.001), compared to the control group but did not significantly differ between active and inactive lesion groups (p=0.17). A significant difference in median CAR (p<0.001) and WBC (p<0.001) was evident among the three groups. Median WBC was significantly higher in the active lesion group compared to the control group (p<0.001) but did not significantly differ between active and inactive lesion groups (p=0.095). Median CAR was significantly higher in the active lesion group, compared both to the inactive lesion group (p=0.002) and the control group (p<0.001). Median CAR was also significantly higher in the inactive lesion group compared to the control group (p<0.001). Median hemoglobin, platelet to lymphocyte ratio and mean platelet volume did not significantly differ among three groups (p=0.16, p=0.85, p=0.19, respectively). Conclusion CAR could be used as a predictive parameter for inflammation and activity of oral ulcers in patients with recurrent aphthous stomatitis.

Authors+Show Affiliations

Department of Otolaryngology, Aksaray University, Faculty of Medicine, Aksaray, TUR.Department of Otolaryngology, Giresun University, Prof Dr A. Ilhan Ozdemir Education and Research Hospital, Giresun, TUR.Department of Otolaryngology, Aksaray University, Aksaray Education and Research Hospital, Aksaray, TUR.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31803551

Citation

Kayabasi, Serkan, et al. "A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio." Cureus, vol. 11, no. 10, 2019, pp. e5965.
Kayabasi S, Hizli O, Cayir S. A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio. Cureus. 2019;11(10):e5965.
Kayabasi, S., Hizli, O., & Cayir, S. (2019). A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio. Cureus, 11(10), pp. e5965. doi:10.7759/cureus.5965.
Kayabasi S, Hizli O, Cayir S. A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio. Cureus. 2019 Oct 22;11(10):e5965. PubMed PMID: 31803551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Novel Predictor Parameter for Active Recurrent Aphthous Stomatitis: C-Reactive Protein to Albumin Ratio. AU - Kayabasi,Serkan, AU - Hizli,Omer, AU - Cayir,Serkan, Y1 - 2019/10/22/ PY - 2019/12/6/entrez PY - 2019/12/6/pubmed PY - 2019/12/6/medline KW - albumin KW - aphthous KW - crp KW - inflammation KW - stomatitis SP - e5965 EP - e5965 JF - Cureus JO - Cureus VL - 11 IS - 10 N2 - Objective Laboratory analysis results may provide an opportunity to predict the activity process of recurrent aphthous stomatitis. The goal of this study was to investigate whether there is a correlation between C-reactive protein to albumin ratio (CAR) and oral ulcer activity in patients with recurrent aphthous stomatitis. Materials and methods We included 72 patients (39 with active and 33 with inactive lesion) with recurrent aphthous stomatitis and 60 healthy controls. We compared blood test parameters including CAR, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) among the groups. Additionally, we investigated the most significant parameter for the activity of oral ulcers. Results NLR was significantly higher both in the active (p<0.001) and inactive lesion groups (p<0.001), compared to the control group but did not significantly differ between active and inactive lesion groups (p=0.17). A significant difference in median CAR (p<0.001) and WBC (p<0.001) was evident among the three groups. Median WBC was significantly higher in the active lesion group compared to the control group (p<0.001) but did not significantly differ between active and inactive lesion groups (p=0.095). Median CAR was significantly higher in the active lesion group, compared both to the inactive lesion group (p=0.002) and the control group (p<0.001). Median CAR was also significantly higher in the inactive lesion group compared to the control group (p<0.001). Median hemoglobin, platelet to lymphocyte ratio and mean platelet volume did not significantly differ among three groups (p=0.16, p=0.85, p=0.19, respectively). Conclusion CAR could be used as a predictive parameter for inflammation and activity of oral ulcers in patients with recurrent aphthous stomatitis. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/31803551/A_Novel_Predictor_Parameter_for_Active_Recurrent_Aphthous_Stomatitis:_C-Reactive_Protein_to_Albumin_Ratio L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31803551/ DB - PRIME DP - Unbound Medicine ER -