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Advances in nanomedicine for the treatment of ankylosing spondylitis.
Int J Nanomedicine 2019; 14:8521-8542IJ

Abstract

Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage-bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward.

Authors+Show Affiliations

Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.Department of Immunology and Microbiology, Institution of Laboratory Medicine of Changshu, Changshu, Jiangsu 215500, People's Republic of China.Department of Pharmaceutics, Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, Nanjing, People's Republic of China.Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.Department of Pharmaceutics, Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, Nanjing, People's Republic of China.Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.Department of Chemical Engineering, Northeastern University, Boston, MA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31806960

Citation

Xi, Yanhai, et al. "Advances in Nanomedicine for the Treatment of Ankylosing Spondylitis." International Journal of Nanomedicine, vol. 14, 2019, pp. 8521-8542.
Xi Y, Jiang T, Chaurasiya B, et al. Advances in nanomedicine for the treatment of ankylosing spondylitis. Int J Nanomedicine. 2019;14:8521-8542.
Xi, Y., Jiang, T., Chaurasiya, B., Zhou, Y., Yu, J., Wen, J., ... Webster, T. J. (2019). Advances in nanomedicine for the treatment of ankylosing spondylitis. International Journal of Nanomedicine, 14, pp. 8521-8542. doi:10.2147/IJN.S216199.
Xi Y, et al. Advances in Nanomedicine for the Treatment of Ankylosing Spondylitis. Int J Nanomedicine. 2019;14:8521-8542. PubMed PMID: 31806960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in nanomedicine for the treatment of ankylosing spondylitis. AU - Xi,Yanhai, AU - Jiang,Tingwang, AU - Chaurasiya,Birendra, AU - Zhou,Yanyan, AU - Yu,Jiangmin, AU - Wen,Jiankun, AU - Shen,Yan, AU - Ye,Xiaojian, AU - Webster,Thomas J, Y1 - 2019/10/29/ PY - 2019/05/18/received PY - 2019/08/13/accepted PY - 2019/12/7/entrez PY - 2019/12/7/pubmed PY - 2019/12/7/medline KW - ankylosing spondylitis KW - environmental factors KW - genetic factors KW - pathogenesis KW - treatment approaches SP - 8521 EP - 8542 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 14 N2 - Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage-bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/31806960/Advances_in_nanomedicine_for_the_treatment_of_ankylosing_spondylitis L2 - https://dx.doi.org/10.2147/IJN.S216199 DB - PRIME DP - Unbound Medicine ER -