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Diamine oxidase supplementation improves symptoms in patients with histamine intolerance.
Food Sci Biotechnol. 2019 Dec; 28(6):1779-1784.FS

Abstract

Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements. The ClinicalTrials.gov identifier (NCT number) is NCT03298568.

Authors+Show Affiliations

Practice for General Internal Medicine, Dr. Theodor Körnerstrasse 19b, 8600 Bruck/Mur, Austria.Das Kinderwunsch Institut Schenk GmbH, Am Sendergrund 11, 8143 Dobl, Austria.3Immunology and Pathophysiology, Otto Loewi Research Centre, Medical University of Graz, Heinrichstrasse 31a, 8010 Graz, Austria.Institute of Laboratory Medicine, General Hospital Steyr, Sierninger Straβe 170, 4400 Steyr, Austria.5Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria.Sciotec Diagnostic Technology GmbH, Ziegelfeldstrasse 3, 3430 Tulln, Austria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31807350

Citation

Schnedl, Wolfgang J., et al. "Diamine Oxidase Supplementation Improves Symptoms in Patients With Histamine Intolerance." Food Science and Biotechnology, vol. 28, no. 6, 2019, pp. 1779-1784.
Schnedl WJ, Schenk M, Lackner S, et al. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019;28(6):1779-1784.
Schnedl, W. J., Schenk, M., Lackner, S., Enko, D., Mangge, H., & Forster, F. (2019). Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Science and Biotechnology, 28(6), 1779-1784. https://doi.org/10.1007/s10068-019-00627-3
Schnedl WJ, et al. Diamine Oxidase Supplementation Improves Symptoms in Patients With Histamine Intolerance. Food Sci Biotechnol. 2019;28(6):1779-1784. PubMed PMID: 31807350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. AU - Schnedl,Wolfgang J, AU - Schenk,Michael, AU - Lackner,Sonja, AU - Enko,Dietmar, AU - Mangge,Harald, AU - Forster,Florian, Y1 - 2019/05/24/ PY - 2018/11/24/received PY - 2019/04/13/revised PY - 2019/05/08/accepted PY - 2019/12/7/entrez PY - 2019/12/7/pubmed PY - 2019/12/7/medline KW - Diamine oxidase KW - Extra-intestinal KW - Gastrointestinal KW - Histamine KW - Malabsorption SP - 1779 EP - 1784 JF - Food science and biotechnology JO - Food Sci. Biotechnol. VL - 28 IS - 6 N2 - Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements. The ClinicalTrials.gov identifier (NCT number) is NCT03298568. SN - 2092-6456 UR - https://www.unboundmedicine.com/medline/citation/31807350/Diamine_oxidase_supplementation_improves_symptoms_in_patients_with_histamine_intolerance_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31807350/ DB - PRIME DP - Unbound Medicine ER -
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