Tags

Type your tag names separated by a space and hit enter

Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome.

Abstract

INTRODUCTION

Rhinitis and obstructive sleep apnea syndrome (OSAS) are different diseases, but have some similar risk factors.

OBJECTIVE

The aims of this study were to compare the risk factors and clinical biomarkers for rhinitis and OSAS in children.

METHODS

We examined 3917 children (age 4-13 years) who were enrolled in a cross-sectional study conducted in Seongnam, Korea. Their parents completed the Pediatric Sleep Questionnaire (PSQ) for evaluation of OSAS and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for evaluation of rhinitis. Clinical biomarkers, including total eosinophil count and neutrophil-lymphocyte ratio (NLR), were measured in a subset of these children.

RESULTS

OSAS and rhinitis had prevalences of 4.0% and 43.5%, respectively. Body mass index (P < 0.001) and prematurity (P = 0.016) were significantly associated with OSAS, but not with rhinitis. Higher parental education and income increased the risk for rhinitis, but decreased the risk for OSAS. Having more siblings and birth by Cesarean delivery decreased the risk for rhinitis, but living in a new household increased the risk for rhinitis. A short distance of the residence to a main road during pregnancy significantly increased the risk of OSAS. Males, increased exposure to mould, and firstborns had increased risk of OSAS and rhinitis. The NLR was higher in OSAS patients than in those with allergic rhinitis (P = 0.001).

CONCLUSION

OSAS and rhinitis shared some risk factors, whereas other factors had inverse association with the two disorders. These results imply that different strategies might be used for prevention of rhinitis and OSAS.

Authors+Show Affiliations

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, Korea.Department of Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31811773

Citation

Ha, Eun Kyo, et al. "Shared and Unique Individual Risk Factors and Clinical Biomarkers in Children With Allergic Rhinitis and Obstructive Sleep Apnea Syndrome." The Clinical Respiratory Journal, 2019.
Ha EK, Park JH, Lee SJ, et al. Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome. Clin Respir J. 2019.
Ha, E. K., Park, J. H., Lee, S. J., Yon, D. K., Kim, J. H., Jee, H. M., ... Han, M. Y. (2019). Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome. The Clinical Respiratory Journal, doi:10.1111/crj.13124.
Ha EK, et al. Shared and Unique Individual Risk Factors and Clinical Biomarkers in Children With Allergic Rhinitis and Obstructive Sleep Apnea Syndrome. Clin Respir J. 2019 Dec 7; PubMed PMID: 31811773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome. AU - Ha,Eun Kyo, AU - Park,Jun Hyeong, AU - Lee,Seung Jin, AU - Yon,Dong Keon, AU - Kim,Ju Hee, AU - Jee,Hye Mi, AU - Lee,Kyung Suk, AU - Sung,Myongsoon, AU - Kim,Mi Ae, AU - Shin,Youn Ho, AU - Han,Man Yong, Y1 - 2019/12/07/ PY - 2019/05/22/received PY - 2019/10/22/revised PY - 2019/12/03/accepted PY - 2019/12/8/pubmed PY - 2019/12/8/medline PY - 2019/12/8/entrez KW - obstructive sleep apnea syndrome KW - prevalence KW - rhinitis KW - risk factor JF - The clinical respiratory journal JO - Clin Respir J N2 - INTRODUCTION: Rhinitis and obstructive sleep apnea syndrome (OSAS) are different diseases, but have some similar risk factors. OBJECTIVE: The aims of this study were to compare the risk factors and clinical biomarkers for rhinitis and OSAS in children. METHODS: We examined 3917 children (age 4-13 years) who were enrolled in a cross-sectional study conducted in Seongnam, Korea. Their parents completed the Pediatric Sleep Questionnaire (PSQ) for evaluation of OSAS and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for evaluation of rhinitis. Clinical biomarkers, including total eosinophil count and neutrophil-lymphocyte ratio (NLR), were measured in a subset of these children. RESULTS: OSAS and rhinitis had prevalences of 4.0% and 43.5%, respectively. Body mass index (P < 0.001) and prematurity (P = 0.016) were significantly associated with OSAS, but not with rhinitis. Higher parental education and income increased the risk for rhinitis, but decreased the risk for OSAS. Having more siblings and birth by Cesarean delivery decreased the risk for rhinitis, but living in a new household increased the risk for rhinitis. A short distance of the residence to a main road during pregnancy significantly increased the risk of OSAS. Males, increased exposure to mould, and firstborns had increased risk of OSAS and rhinitis. The NLR was higher in OSAS patients than in those with allergic rhinitis (P = 0.001). CONCLUSION: OSAS and rhinitis shared some risk factors, whereas other factors had inverse association with the two disorders. These results imply that different strategies might be used for prevention of rhinitis and OSAS. SN - 1752-699X UR - https://www.unboundmedicine.com/medline/citation/31811773/Shared_and_unique_individual_risk_factors_and_clinical_biomarkers_in_children_with_allergic_rhinitis_and_obstructive_sleep_apnea_syndrome L2 - https://doi.org/10.1111/crj.13124 DB - PRIME DP - Unbound Medicine ER -