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Adjuvant regional nodal irradiation did not improve outcomes in T1-2N1 breast cancer after breast-conserving surgery: A propensity score matching analysis of BIG02/98 and BCIRG005 trials.
Breast 2019; 49:165-170B

Abstract

AIM

To determine whether the addition of regional nodal irradiation (RNI) to whole-breast irradiation (WBI) would improve outcomes over WBI alone in T1-2N1 breast cancer after breast-conserving surgery (BCS) and adjuvant systematic therapy.

METHODS

Data were obtained from two randomized controlled trials (NCT00174655 and NCT00312208). Univariate and multivariate Cox-regression analysis were performed to investigate predictors for overall survival and disease-free survival. A 1:1 propensity score matching (PSM) analysis was applied to eliminate selection bias.

RESULTS

With median follow-up 80 months (range: 3-155 months), the 5-year local regional recurrence in the WBI group was 2% vs. 5% (p = 0.28) in the WBI + supraclavicular radiotherapy, and the rate of 5-year distant metastasis in the WBI group was 7% vs. 13% in the WBI + supraclavicular radiotherapy (p = 0.0748); In addition, the 5-year local regional recurrence in the WBI group was 3% vs. 9% (p = 0.19) in the WBI + internal mammary irradiation (IMI); However, the rate of 5-year distant metastasis in the in the WBI group was significantly lower than that in the WBI + IMI (8% vs. 24%, p = 0.036). After PSM, cox-regression analysis indicated that neither RNI nor IMI in combination with WBI in T1-2N1 breast cancer was associated with an improved overall survival and disease-free survival when compared to WBI alone.

CONCLUSION

The addition of RNI to WBI in T1-2N1 breast cancer after BCS and adjuvant systematic therapy did not improve outcomes in comparison with WBI alone. Further studies are still needed to identify patients who would most benefit from RNI in this patient population.

Authors+Show Affiliations

Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: zsg10935@rjh.com.cn.Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: chenjiayi0188@aliyun.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31812892

Citation

Qi, Wei-Xiang, et al. "Adjuvant Regional Nodal Irradiation Did Not Improve Outcomes in T1-2N1 Breast Cancer After Breast-conserving Surgery: a Propensity Score Matching Analysis of BIG02/98 and BCIRG005 Trials." Breast (Edinburgh, Scotland), vol. 49, 2019, pp. 165-170.
Qi WX, Cao L, Xu C, et al. Adjuvant regional nodal irradiation did not improve outcomes in T1-2N1 breast cancer after breast-conserving surgery: A propensity score matching analysis of BIG02/98 and BCIRG005 trials. Breast. 2019;49:165-170.
Qi, W. X., Cao, L., Xu, C., Zhao, S., & Chen, J. (2019). Adjuvant regional nodal irradiation did not improve outcomes in T1-2N1 breast cancer after breast-conserving surgery: A propensity score matching analysis of BIG02/98 and BCIRG005 trials. Breast (Edinburgh, Scotland), 49, pp. 165-170. doi:10.1016/j.breast.2019.11.001.
Qi WX, et al. Adjuvant Regional Nodal Irradiation Did Not Improve Outcomes in T1-2N1 Breast Cancer After Breast-conserving Surgery: a Propensity Score Matching Analysis of BIG02/98 and BCIRG005 Trials. Breast. 2019 Nov 29;49:165-170. PubMed PMID: 31812892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjuvant regional nodal irradiation did not improve outcomes in T1-2N1 breast cancer after breast-conserving surgery: A propensity score matching analysis of BIG02/98 and BCIRG005 trials. AU - Qi,Wei-Xiang, AU - Cao,Lu, AU - Xu,Cheng, AU - Zhao,Shengguang, AU - Chen,Jiayi, Y1 - 2019/11/29/ PY - 2019/09/05/received PY - 2019/10/16/revised PY - 2019/11/01/accepted PY - 2019/12/10/pubmed PY - 2019/12/10/medline PY - 2019/12/9/entrez KW - Breast cancer KW - Breast conserving surgery KW - Propensity score matching analysis KW - Regional nodal irradiation KW - T1-2N1 SP - 165 EP - 170 JF - Breast (Edinburgh, Scotland) JO - Breast VL - 49 N2 - AIM: To determine whether the addition of regional nodal irradiation (RNI) to whole-breast irradiation (WBI) would improve outcomes over WBI alone in T1-2N1 breast cancer after breast-conserving surgery (BCS) and adjuvant systematic therapy. METHODS: Data were obtained from two randomized controlled trials (NCT00174655 and NCT00312208). Univariate and multivariate Cox-regression analysis were performed to investigate predictors for overall survival and disease-free survival. A 1:1 propensity score matching (PSM) analysis was applied to eliminate selection bias. RESULTS: With median follow-up 80 months (range: 3-155 months), the 5-year local regional recurrence in the WBI group was 2% vs. 5% (p = 0.28) in the WBI + supraclavicular radiotherapy, and the rate of 5-year distant metastasis in the WBI group was 7% vs. 13% in the WBI + supraclavicular radiotherapy (p = 0.0748); In addition, the 5-year local regional recurrence in the WBI group was 3% vs. 9% (p = 0.19) in the WBI + internal mammary irradiation (IMI); However, the rate of 5-year distant metastasis in the in the WBI group was significantly lower than that in the WBI + IMI (8% vs. 24%, p = 0.036). After PSM, cox-regression analysis indicated that neither RNI nor IMI in combination with WBI in T1-2N1 breast cancer was associated with an improved overall survival and disease-free survival when compared to WBI alone. CONCLUSION: The addition of RNI to WBI in T1-2N1 breast cancer after BCS and adjuvant systematic therapy did not improve outcomes in comparison with WBI alone. Further studies are still needed to identify patients who would most benefit from RNI in this patient population. SN - 1532-3080 UR - https://www.unboundmedicine.com/medline/citation/31812892/Adjuvant_regional_nodal_irradiation_did_not_improve_outcomes_in_T1-2N1_breast_cancer_after_breast-conserving_surgery:_A_propensity_score_matching_analysis_of_BIG02/98_and_BCIRG005_trials L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-9776(19)30593-4 DB - PRIME DP - Unbound Medicine ER -