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Reduction of oral toxicity of 5-fluorouracil by allopurinol mouthwashes.
Eur J Surg Oncol. 1988 Oct; 14(5):405-6.EJ

Abstract

5-Fluorouracil (5-FU) is the most effective drug in gastrointestinal cancer. Mucositis and bone marrow toxicity are the two major limiting side effects. In our effort to reduce mucositis we administered 'Allopurinol' mouthwash in 16 patients who had experienced oral mucositis during prior treatment with 5-FU. In all patients significant reduction of oral toxicity was noticed as well as prolonged pain relief. This observation must be tested by controlled clinical trial.

Authors+Show Affiliations

Second Department of Medical Oncology, Metaxas Cancer Hospital, Piraeus, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3181443

Citation

Tsavaris, N, et al. "Reduction of Oral Toxicity of 5-fluorouracil By Allopurinol Mouthwashes." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 14, no. 5, 1988, pp. 405-6.
Tsavaris N, Caragiauris P, Kosmidis P. Reduction of oral toxicity of 5-fluorouracil by allopurinol mouthwashes. Eur J Surg Oncol. 1988;14(5):405-6.
Tsavaris, N., Caragiauris, P., & Kosmidis, P. (1988). Reduction of oral toxicity of 5-fluorouracil by allopurinol mouthwashes. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 14(5), 405-6.
Tsavaris N, Caragiauris P, Kosmidis P. Reduction of Oral Toxicity of 5-fluorouracil By Allopurinol Mouthwashes. Eur J Surg Oncol. 1988;14(5):405-6. PubMed PMID: 3181443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of oral toxicity of 5-fluorouracil by allopurinol mouthwashes. AU - Tsavaris,N, AU - Caragiauris,P, AU - Kosmidis,P, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 405 EP - 6 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 14 IS - 5 N2 - 5-Fluorouracil (5-FU) is the most effective drug in gastrointestinal cancer. Mucositis and bone marrow toxicity are the two major limiting side effects. In our effort to reduce mucositis we administered 'Allopurinol' mouthwash in 16 patients who had experienced oral mucositis during prior treatment with 5-FU. In all patients significant reduction of oral toxicity was noticed as well as prolonged pain relief. This observation must be tested by controlled clinical trial. SN - 0748-7983 UR - https://www.unboundmedicine.com/medline/citation/3181443/Reduction_of_oral_toxicity_of_5_fluorouracil_by_allopurinol_mouthwashes_ DB - PRIME DP - Unbound Medicine ER -