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Effect of axial prestretch and adipose tissue on the inflation-extension behavior of the human abdominal aorta.

Abstract

Our study aims to show that perivascular adipose tissue may significantly change the mechanical state of the abdominal aorta. To this end, uniaxial tensile tests with perivascular fat tissue were carried out. In the subsequent regression analysis, stress-strain data were fitted by the polynomial strain energy density. A constitutive model of adipose tissue was used in the analytical simulation of the inflation-extension behavior of the human abdominal aorta. The computational model was based on the theory of the bi-layered thick-walled tube. In addition to the effect of perivascular tissue, the effect of axial prestretch was also studied. It was found that the presence of perivascular tissue reduces the distensibility of the aorta. Axial prestretch applied to the aorta embedded in adipose tissue had an effect opposite to that of adipose tissue. Axially prestrained aorta exhibited higher distensiblity than non-prestrained aorta. It was also shown that the perivascular envelope bears some portion of the pressure loading and thus reduces the mechanical stresses inside the wall of aorta. A similar effect was found for axial prestretch.

Authors+Show Affiliations

Faculty of Mechanical Engineering, Czech Technical University in Prague, Prague, Czech Republic.Faculty of Mechanical Engineering, Czech Technical University in Prague, Prague, Czech Republic.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31814443

Citation

Voňavková, Tereza, and Lukáš Horný. "Effect of Axial Prestretch and Adipose Tissue On the Inflation-extension Behavior of the Human Abdominal Aorta." Computer Methods in Biomechanics and Biomedical Engineering, 2019, pp. 1-11.
Voňavková T, Horný L. Effect of axial prestretch and adipose tissue on the inflation-extension behavior of the human abdominal aorta. Comput Methods Biomech Biomed Engin. 2019.
Voňavková, T., & Horný, L. (2019). Effect of axial prestretch and adipose tissue on the inflation-extension behavior of the human abdominal aorta. Computer Methods in Biomechanics and Biomedical Engineering, pp. 1-11. doi:10.1080/10255842.2019.1699544.
Voňavková T, Horný L. Effect of Axial Prestretch and Adipose Tissue On the Inflation-extension Behavior of the Human Abdominal Aorta. Comput Methods Biomech Biomed Engin. 2019 Dec 9;1-11. PubMed PMID: 31814443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of axial prestretch and adipose tissue on the inflation-extension behavior of the human abdominal aorta. AU - Voňavková,Tereza, AU - Horný,Lukáš, Y1 - 2019/12/09/ PY - 2019/12/10/entrez PY - 2019/12/10/pubmed PY - 2019/12/10/medline KW - Adipose tissue KW - aorta KW - axial prestretch KW - constitutive model KW - hyperelasticity KW - thick-walled tube SP - 1 EP - 11 JF - Computer methods in biomechanics and biomedical engineering JO - Comput Methods Biomech Biomed Engin N2 - Our study aims to show that perivascular adipose tissue may significantly change the mechanical state of the abdominal aorta. To this end, uniaxial tensile tests with perivascular fat tissue were carried out. In the subsequent regression analysis, stress-strain data were fitted by the polynomial strain energy density. A constitutive model of adipose tissue was used in the analytical simulation of the inflation-extension behavior of the human abdominal aorta. The computational model was based on the theory of the bi-layered thick-walled tube. In addition to the effect of perivascular tissue, the effect of axial prestretch was also studied. It was found that the presence of perivascular tissue reduces the distensibility of the aorta. Axial prestretch applied to the aorta embedded in adipose tissue had an effect opposite to that of adipose tissue. Axially prestrained aorta exhibited higher distensiblity than non-prestrained aorta. It was also shown that the perivascular envelope bears some portion of the pressure loading and thus reduces the mechanical stresses inside the wall of aorta. A similar effect was found for axial prestretch. SN - 1476-8259 UR - https://www.unboundmedicine.com/medline/citation/31814443/Effect_of_axial_prestretch_and_adipose_tissue_on_the_inflation-extension_behavior_of_the_human_abdominal_aorta L2 - http://www.tandfonline.com/doi/full/10.1080/10255842.2019.1699544 DB - PRIME DP - Unbound Medicine ER -