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Determination of 21 synthetic cathinones, phenethylamines, amphetamines and opioids in influent wastewater using liquid chromatography coupled to tandem mass spectrometry.
Talanta. 2020 Feb 01; 208:120479.T

Abstract

Human consumption of illicit novel psychoactive substances (NPS) is a continuing problem. New derivatives are constantly appearing, circumventing national and international laws. The use of these compounds tend to be sporadic and many are consumed as mixtures, meaning very low amounts of each are detectable at any one time. The analysis of excreted NPS in wastewater provides information on community prevalence. A wastewater-based epidemiology approach has been applied in the current study for the quantification of 21 NPS. These include three phenethylamines (25B-NBOMe, 25C-NBOMe, 25I-NBOMe), ten synthetic cathinones (3-ethylmethcathinone (3-EMC), 3-methylbuphedrone, 3-methylmethcathinone (3-MMC), 4-fluoromethcathinone (4-FMC), 4-methylbuphedrone, 4-methylethcathinone (4-MEC), buphedrone, butylone, N-ethylpentylone and pentylone), five synthetic opioid analgesics (AH-7921, butyryl fentanyl, furanyl fentanyl, U-47700 and valeryl fentanyl) as well as the synthetic amphetamine 4-fluoroamphemtaine (4-FA), ketamine analogue methoxetamine and methiopropamine. Limits of detection were between 0.01 and 0.5 ng/L and limits of quantification were between 0.05 and 1 ng/L. The method was applied to wastewater samples from South Australia collected over the Christmas-New Year period when recreational drug use tends to be high. Seven NPS (butylone, butyryl fentanyl, furanyl fentanyl, methoxetamine, N-ethylpentylone, pentylone and valeryl fentanyl) were found, with N-ethylpentylone showing the highest mass loads at 36 mg/day/1000 inhabitants.

Authors+Show Affiliations

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia. Electronic address: richard.bade@unisa.edu.au.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia. Electronic address: cobus.gerber@unisa.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31816707

Citation

Bade, Richard, et al. "Determination of 21 Synthetic Cathinones, Phenethylamines, Amphetamines and Opioids in Influent Wastewater Using Liquid Chromatography Coupled to Tandem Mass Spectrometry." Talanta, vol. 208, 2020, p. 120479.
Bade R, Abdelaziz A, Nguyen L, et al. Determination of 21 synthetic cathinones, phenethylamines, amphetamines and opioids in influent wastewater using liquid chromatography coupled to tandem mass spectrometry. Talanta. 2020;208:120479.
Bade, R., Abdelaziz, A., Nguyen, L., Pandopulos, A. J., White, J. M., & Gerber, C. (2020). Determination of 21 synthetic cathinones, phenethylamines, amphetamines and opioids in influent wastewater using liquid chromatography coupled to tandem mass spectrometry. Talanta, 208, 120479. https://doi.org/10.1016/j.talanta.2019.120479
Bade R, et al. Determination of 21 Synthetic Cathinones, Phenethylamines, Amphetamines and Opioids in Influent Wastewater Using Liquid Chromatography Coupled to Tandem Mass Spectrometry. Talanta. 2020 Feb 1;208:120479. PubMed PMID: 31816707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of 21 synthetic cathinones, phenethylamines, amphetamines and opioids in influent wastewater using liquid chromatography coupled to tandem mass spectrometry. AU - Bade,Richard, AU - Abdelaziz,Ahmed, AU - Nguyen,Lynn, AU - Pandopulos,Aaron J, AU - White,Jason M, AU - Gerber,Cobus, Y1 - 2019/10/18/ PY - 2019/08/09/received PY - 2019/10/11/revised PY - 2019/10/15/accepted PY - 2019/12/11/entrez PY - 2019/12/11/pubmed PY - 2019/12/11/medline KW - Australia KW - Matrix effects KW - New Year KW - Novel psychoactive substances KW - Stability SP - 120479 EP - 120479 JF - Talanta JO - Talanta VL - 208 N2 - Human consumption of illicit novel psychoactive substances (NPS) is a continuing problem. New derivatives are constantly appearing, circumventing national and international laws. The use of these compounds tend to be sporadic and many are consumed as mixtures, meaning very low amounts of each are detectable at any one time. The analysis of excreted NPS in wastewater provides information on community prevalence. A wastewater-based epidemiology approach has been applied in the current study for the quantification of 21 NPS. These include three phenethylamines (25B-NBOMe, 25C-NBOMe, 25I-NBOMe), ten synthetic cathinones (3-ethylmethcathinone (3-EMC), 3-methylbuphedrone, 3-methylmethcathinone (3-MMC), 4-fluoromethcathinone (4-FMC), 4-methylbuphedrone, 4-methylethcathinone (4-MEC), buphedrone, butylone, N-ethylpentylone and pentylone), five synthetic opioid analgesics (AH-7921, butyryl fentanyl, furanyl fentanyl, U-47700 and valeryl fentanyl) as well as the synthetic amphetamine 4-fluoroamphemtaine (4-FA), ketamine analogue methoxetamine and methiopropamine. Limits of detection were between 0.01 and 0.5 ng/L and limits of quantification were between 0.05 and 1 ng/L. The method was applied to wastewater samples from South Australia collected over the Christmas-New Year period when recreational drug use tends to be high. Seven NPS (butylone, butyryl fentanyl, furanyl fentanyl, methoxetamine, N-ethylpentylone, pentylone and valeryl fentanyl) were found, with N-ethylpentylone showing the highest mass loads at 36 mg/day/1000 inhabitants. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/31816707/Determination_of_21_synthetic_cathinones,_phenethylamines,_amphetamines_and_opioids_in_influent_wastewater_using_liquid_chromatography_coupled_to_tandem_mass_spectrometry L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(19)31112-9 DB - PRIME DP - Unbound Medicine ER -
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